5N96,5AOR,6HYT,7DCQ,2XAU,6H57


Conserved Protein Domain Family
OB_NTP_bind
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pfam07717: OB_NTP_bind 
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Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
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Statistics
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PSSM-Id: 400182
Aligned: 58 rows
Threshold Bit Score: 42.6247
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5N96_A        767 LRAIIGAGLYPNMA------------------HLR----------KSRQiknrvrAIHTmaTd-----------dGRRVN 807  fruit fly
Q06698       1205 LRAILTGAFYPHIArvqlpdvkylstssgaveKDPeakmikywirSEEYqdkleeYKTKisQetqkvdledlplpATRAF 1284 Saccharomyces...
Q7R865        976 IKKCIISGFFTNAAl-----------------PIN----------KTE-------LKII--Kl------------NQVVS 1007 Plasmodium yo...
XP_961050    1221 LRALTASAFSPQIAriqfpdkkfaasmtgaveLDP----------EAKT------IKFF--Sq-----------eNGRVF 1271
O94536       1158 LSTLIAAALSPNVVkcvypdkkfvasfsgsleMEQ----------EARLtk---fYDQN----------------NQRLF 1208 Schizosacchar...
XP_001708567  539 LLPFIKAGLYNVLR------------------RNS----------SGPSv----tYSRLskEd-----------nSEEIL 575 
CDH93106      543 VRVIIAAGLYPNFSi-----------------LDP----------VNKYgygqemFTHT--Rl------------KPFTQ 581 
Q9DBV3        800 LKLVLGRGLYPQLAv-----------------PDAf--------nSGRKdsdqifHTQA----------------KQGTV 838  house mouse
Q9VWI5        786 LKLLLGSGFYPQLAi-----------------SDEf--------nYCKGggqqffHTRL----------------KPFVL 824  fruit fly
Q9W1I2        862 VKAALTGGMYPNIYa-----------------VDT----------RKSS------LKSA--F-------------SGNVS 893  fruit fly

5N96_A        808 FHPSSVNS--------GESGFDSA-----------------------YFVYFQRQKSTDLFLLDSTMVFPM-ALIIFGDG 855  fruit fly
Q06698       1285 IHPSSVLFs------tNSVNLEDAkllsevdgpisrqskiptvvkypFVLFTTSQVTNKLYLRDLTPTTTL-SLLLFGGA 1357 Saccharomyces...
Q7R865       1008 IYPSSVLSkk-----nIMEEYHNS-----------------------CIIFYEVIKINKSYIRYNINVNKD-LLFEIASF 1058 Plasmodium yo...
XP_961050    1272 IHPSSTLFd------sQGFTGNAS-----------------------FMSYFTKIATSKIFIRDLTPFNAY-TLLLFSGA 1321
O94536       1209 IHPSSTMFv------nSPNASRCT-----------------------FVAYEQKVETTKPFLRNCTPINTY-GMILLGAN 1258 Schizosacchar...
XP_001708567  576 IHLSSCLRn-----------SANR-----------------------FIICETILSTTALYACVCSPVSAK-ALAMLFPH 620 
CDH93106      582 IHPNSSIAq------yHPETIDPRqgsdgf------------srlhqIPFYGLLLETTKPYICNVMPVPAVyTLLV-AQK 642 
Q9DBV3        839 LHPTCVFAnspevlhtQGQEASGQegsqdgrd--------qmsckhqLLAFVSLLETNKPYLVNCVRIPALqSLLLFSRS 910  house mouse
Q9VWI5        825 QHPNSQFAkhfellklTESDLLPKpdfytpkl--------plskrhqLLCYQSLLETAKPYLINCIRLPAAqTLLLFSFA 896  fruit fly
Q9W1I2        894 MHPNTVLRdfleplniSAQSFRTP-----------------------WIVCNR----QKSHIVYATLVVPL-AVAMFSGH 945  fruit fly

5N96_A        856 -V 856  fruit fly
Q06698       1358 -I 1358 Saccharomyces cerevisiae S288C
Q7R865       1059 -Y 1059 Plasmodium yoelii yoelii
XP_961050    1322 -I 1322
O94536       1259 dI 1260 Schizosaccharomyces pombe 972h-
XP_001708567  621 -M 621 
CDH93106      643 -I 643 
Q9DBV3        911 -I 911  house mouse
Q9VWI5        897 -I 897  fruit fly
Q9W1I2        946 pr 947  fruit fly
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