4P9F,3C7J


Conserved Protein Domain Family
FCD
?
pfam07729: FCD 
Click on image for an interactive view with Cn3D
FCD domain
This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).
Links
?
Statistics
?
PSSM-Id: 429623
Aligned: 168 rows
Threshold Bit Score: 38.8897
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4P9F_A         78 EINRI---RYELELXAVALAVENLTPQD-LAELQELL--EKLQQAq-----eKGDXEq------IINVNRLFRLAIYHRS 140
Q5YZB7        103 DIAEM---RRSVAADSARLCAERAEPRR-VDTIVAAA--AAYPEPt-----aALDD--------LISGDLAFWTAVIDGS 163 Nocardia farci...
jgi:Xaut_3347 116 EMATA---RLEMEAVCCRLAAQNRTDAH-LAALEAEI--ALQKNAa-----vSDQD--------FCASDVRFHRAVVDAA 176
jgi:Noca_0841 111 NLVET---RLGIELAIVTALAERGTDAD-FDALEALL--DEQQEHl-----eNDPS--------YQWEPLGFELTAAGMC 171
Q63KE6         97 hLLAV---RRAIEAEVAAEAALCRTDED-MEDIDAAL--AKIDDAv-----aEGRD--------GVAEDVAFHRTIASVT 157 Burkholderia p...
jgi:Veis_2716 244 EVAEA---RAAVELQVIRFAAQRITDNG-LARLSSLV--KEQELMl-------kDPVg------FQISDREFHTTLYKSC 304
Q0RIP2         82 VIAEA---RAAVEPTMLRMSISRGDLEW-ETRVRAAH--HRLAGTp-----pFEHDGdahfsdaWAAAHHGFHRALLDAC 150 Frankia alni A...
WP_011803673  103 DITTL---RVHIETDALRQSIRAGDAQW-REALAEAY--AAISAEeqpiaphRRRQ--------WELLNVRFHEALLAGH 168 Diaphorobacter...
CAL78809       84 ELAELtktRCWVEALALRESMKAATPPW-EEQLVLAQ--HRLSRAp-----rSLSATtfednpeWEKLHRIYHRVLIANC 155
CAV17400       82 DLYES---LRVVSSVLLKKAISAGDESWeLEVLTSYHklSRIQYVs-----eEFDCVe------WEERHQQFHAALLEGA 147

4P9F_A        141 NXPILCeXIEQLWVRXGP---GLHYLYEaiNPAELREHIEN--YHLLLAALKAKDKEGCRHCLAE 200
Q5YZB7        164 GNLAYRlALNTLVAGYTD---IGWETIV--RLGLNREYLDRarHRELADRIAARDPEGAHRHAHA 223 Nocardia farcinica
jgi:Xaut_3347 177 GNALLRfLMNAVVEALMP---VSNMIIF--RVRDRKEIVGH--HERMLAALRERDGEAAVEALGG 234
jgi:Noca_0841 172 GNSWLYdVELLLRDAWVT---LSRGTRT--RVSRHREWHSE--HRAILASMRTRNVRQAQRLVMA 229
Q63KE6        158 GNPYFLkTLSFLNQYLEAgvkVTRGNEAt-REDFSRQVREE--HAAIADAIRARDPSAAGNAARA 219 Burkholderia pseudomallei
jgi:Veis_2716 305 GNSLLVdVVSDFYDYALE---YRRRALQ--RPGAIKHSVQD--HKEIVDALKTRNPDAAVAAMRG 362
Q0RIP2        151 GNDVLLdTFERLWTASEL---SRRWSA---AGNPARNYLAE--HRRLERLALSRQSEAAADALVT 207 Frankia alni ACN14a
WP_011803673  169 DSPWTVrVLRLLSRHSER---YRFCAMG--LPGGVRDVHAE--HTEIFELAMSGQDARAALALEA 226 Diaphorobacter sp. MNS-0
CAL78809      156 GSQSLVaFCGQLADQLYR---YRRLSIR--KAFPSRAVGDE--HAAIVNAVLNADVEGAVALLTA 213
CAV17400      148 DSENMFkFFDDLINQVKR---YRFLAMSakSASDDLFNIDE--HEMIMKLVLAKNVDQATELLDQ 207
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap