Conserved Protein Domain Family
TCTN_DUF1619

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pfam07773: TCTN_DUF1619 
Tectonic domain DUF1619
This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.
Statistics
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PSSM-Id: 462260
Aligned: 58 rows
Threshold Bit Score: 146.922
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002503963         75 CLCDLTEGTCDANCCCDPDCDSNEKAQFTECATCVYD-GAnaamngkvclpegrsppslEYCLPSSTVSRVNL---LSSS 150
EEC12108             74 CFCDLKRNSCDVECCCDSDCTEDDAKSFSFCVDRVPEaPDl------------------RYCTKRDAIFASRT------- 128
EFX86661            116 CTCDLIGGQCDVNCCCDPDCSQDDLRLFNGCWSPPSSyFDr------------------YYCSPDP----DRYglvWNNT 173
EGI68878            212 CECDLIKSSCNINCCCDIDCNHSHLSAFSYCQNYHVElYDs------------------RYCYNRNFIQRNNT------- 266
EDS36993              9 YYENRRINICDVNCCCDIDCSDQILRTFS--------------------------------CSEER------LdvaEYHH 50 
Q16V00              262 CKCDLKINICDVNCCCDIDCSESVLRTFA--------------------------------CDEEE------LdieEYHH 303 yellow f...
WGS:AAQB:GK15385-PA 129 CSCDLREGICDLNCCCDRDCPSEILVVFN--------------------------------CLGLEAPAELQTrleDFQY 176
WGS:AAPU:GI17529-PA 149 CSCDLRQDLCEVNCCCDRDCSQESLQVFS--------------------------------CLPEQ---HTRLe--DFQY 191
Q9VMH0              117 CSCDLQAGRCDLNCCCDNDCPLETRQVFN--------------------------------CLPNSLLPQLESrleDFQY 164 fruit fly
XP_001962306        116 CSCDVQAGRCNLNCCCDHDCNSEVRKVFS--------------------------------CLSSTTSPEVQAkleDFQY 163
XP_002503963        151 SLGVVeqrkadmsflsqqlCIKDD-NSAS-----LGKYFLDP-GFATDdi-lkSSVTLQS--ERFWNPVPAAASe----- 215
EEC12108            129 ---LFekrpv-----gdllCVVVDnVRKK-------DVFGEPpSVSSPad--vHKLVEESrhGWMADGAEQTT------- 184
EFX86661            174 PEFRVqwssr-----sgmfCIVTDnVPKK-------RLFQDQaPVTEDel--fKQISPKLsgRWNDPESQPASAgleqwi 239
EGI68878            267 --PFIfekla-----nnlfCILYDnLPSIy-------------STNNNlvlyeEELWKIIemNNYKWEIRHSKTlfk-yn 325
EDS36993             51 REGLQscevq-----gglfCLVGEhRPPEegedgGGVFYDP--NLKESss------kyKWseIFPVGDVPKRGP------ 111
Q16V00              304 QEGLQscevq-----gglfCLVGErRDTT-----RGTVSKKFrNLNHAasnyeIATKRKWidIFPVDTNSKDKI------ 367 yellow f...
WGS:AAQB:GK15385-PA 177 THGLPtcqlh-----dgwlCVFRSnTKPV--------------KMQPIfrdfdSSKYRKWpdLLEAYETDNVPSt----- 232
WGS:AAPU:GI17529-PA 192 NHGLPtcqis-----dgwlCVFRShTKPA--------------KKQTPsqifdSKDYNRWpeQLDAFETALPAPp----- 247
Q9VMH0              165 THGLPtcqin-----dgwlCVFRSnTKAT--------------KTQPPdmnidTSQYRKWkdNLEYQESDYAQSrp---- 221 fruit fly
XP_001962306        164 NHGLPscqin-----dgwlCVFRSnLKPT--------------NVPALslnlnADSQKKWp-dLEAYDGNPIETrs---- 219
XP_002503963        216 tQPKYRHNDTIGVVKAASEpllpGNKFVLPGATFSGVCGWTNVIGYnmplpasAA-SEDATCLVPIDDTlSKSCTTL--- 291
EEC12108            185 -KVRFKAGDALLRLEDDGG----VGEWSECVGASFTACEATEAVTY-------LR-DQVFECTRGVGVL-DNWCTSDp-- 248
EFX86661            240 yQPYYKQGSPIFTLHINGI----VSVLKLPRSLNSASCNTAQTVHF-------LEsDNDYQCSLPG----EDRCRPT--- 301
EGI68878            326 lSKYYQHGDILWKLHDKS-----IEEIEFLQSGFTGICTFKKILRY-------LQ-NWKGACI-------QNKLTNInpy 385
EDS36993            112 -VSTYRVNDRIKLYNETSEk---IETLTLPFSLTNSECQLAQPVRY-------LR-DQSTEC--------LRSLEDLelf 171
Q16V00              368 -ASSYRVNDIIKFYNETSEh---VEPFNLPRSLTNSECQILQPIRF-------LQ-DQTTECL-------RTSLDELesf 428 yellow f...
WGS:AAQB:GK15385-PA 233 -QSHYKLGQALQLWHPESKe---SSVFMLPTSYETAHCHIRQAIRH-------LQ-PTENNCL-------MNDINQLqen 293
WGS:AAPU:GI17529-PA 248 mTSHYKFGQALQLWQPESKs---LANWELPMAYESASCQLKQTLLY-------LQ-PMESSCL-------LADATQLqmn 309
Q9VMH0              222 sAGHYKFGQTLQLWQPETKq---LATLELPAAYESPNCQLKQSVWH-------LQ-PIRHVCR-------MKDSAQLqes 283 fruit fly
XP_001962306        220 sSLYYKFGEPLQLWQPESNe---LTTLELPISYESSQCKLKQAVRH-------LQ-SVSSHCP-------MKDANQLqes 281
XP_002503963        292 -L--NAKYLVNDLKLak-tPGSSAT-PTEAPTISSMKYRSRIGGKLTDLTGTVpaatftd---------gsggsgaAD-- 355
EEC12108            249 aL--SAQTYYRGFAI-----------------------------------SSSaedrvqvlptlcsgdvcsdfppsAHva 291
EFX86661            302 -I--RLEEWLANLAV---------------FRLPSYSVSSNGNAGNSSARWGDmdklapvvvricensdsgcrsdlPApe 363
EGI68878            386 lFtvT----FSNFTV----------------------IKSLPSFNDTLTTNQMcqsniclpvrihyclksfsacnrTSis 439
EDS36993            172 nL--ALLEQQAFVRYlrspKAEIMEhCLDE-------------------------------------------------- 199
Q16V00              429 tT--TLMEQQSHLRYlrlpKAEIMEhCMDQ-------------------------------------------------- 456 yellow f...
WGS:AAQB:GK15385-PA 294 lA--LILNITSNYQVlgkpRDIEET-EVEGINMQ---------------------------------------------- 324
WGS:AAPU:GI17529-PA 310 lW--SLLNLTNSHQLl--sRPRELE-EQQVHGLNITICQQLLLQPKIQCLEhn--------------------------- 357
Q9VMH0              284 iW--SLLNQTSNYEIlskpRDLEEP-EVNGLIVQ---------------------------------------------- 314 fruit fly
XP_001962306        282 lW--DIMNFTSTSQLlgkpRDPEET-EHDGITIQ---------------------------------------------- 312
XP_002503963        356 ------TCNF------------------------------AVVEAHYVITHDGSgSISSFAVDL-VFADVMTSTrwsavy 398
EEC12108            292 sytddgECRN------------------------------VVSQVTYRIVHNGVhGIINITARY-ETTTLQSGAt----- 335
EFX86661            364 -----pSCRN------------------------------SLAAVTLRIAHNGTeGIRSVLADL-LYTSASAGA------ 401
EGI68878            440 gfcmnsTCTN------------------------------IVKGLKYVIRHNGSaGINSIDAYF-NIGNASH-------- 480
EDS36993            200 ------DCFNssvrfcdlsgqncqktnqssvndpegsyswYCPEVKIRFVHNYT-HLTAMETRL-LCGSIDLEQd----- 266
Q16V00              457 ------DCFNssiqfcsfaglncrttnssesnddgsgepwYCPRINFEFQHNYT-HLEGLNIKL-LCGRAELFDmk---- 524 yellow f...
WGS:AAQB:GK15385-PA 325 ------ICQLwqsvnltrklac-------fdqandtqldmIVDKIELEFLHNYT-NILGVKLLL-REAPTRQTEs----- 384
WGS:AAPU:GI17529-PA 358 ----etQSEL------------------------------LVDRIELQLLHNYT-NILEAKLLL-REASVEDDKt----- 396
Q9VMH0              315 ------VCLRganksmrcle-----------rgndtqldvIVDHVELQLIHNFT-NILEAKLFL-EEAKLAEDDn----- 370 fruit fly
XP_001962306        313 ------VCQRdvggktvcek-----------qgnetqldaLPEALELQFIHNFT-NILEAKLIIgPSASWTEDEn----- 369
XP_002503963        399 nangaladpgnpsSVRVKYTVSW--------KLSaetvvpRSGAPGYVVGAP 442
EEC12108            336 -------------EFLQRFRTFYvwlsdgisPAAe-----RSGNPGYLPGLP 369
EFX86661            402 -------------VRFQTIHQSLgemnrpsgGANnpl-rtRSGNPGYLTGKP 439
EGI68878            481 -------------PFYQYFEVEYkwidsnntQIFi-----RSGNLGYEMGKP 514
EDS36993            267 -------------TIWQRISVEFkrkdeekfSRK------VSGNLGYLVGKP 299
Q16V00              525 -----------gdKIWTRLSVKFtrkneekfSRS------VSGNLGYLKGKP 559 yellow fever mosquito
WGS:AAQB:GK15385-PA 385 ------------eELWLHYKVSFksvn-etaSKP------ISGPLGYLTGKP 417
WGS:AAPU:GI17529-PA 397 -------------MLWLTYALVYqsveelntKPS-------SGALGYELGAP 428
Q9VMH0              371 ------------ePLWLRYNVEFvtln-eslTKP------TSGPLGYLSGAP 403 fruit fly
XP_001962306        370 ------------ePVWLTYEVTFisvn-epiAKP------TSGPLGYL---P 399
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