Conserved Protein Domain Family
TMC
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pfam07810: TMC 
TMC domain
These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.
Links
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Statistics
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PSSM-Id: 462275
Aligned: 85 rows
Threshold Bit Score: 103.378
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015788900  884 CWETMFGQELAKILVADTLLGIVITIVADYGRALFVRYCNDCscifwdLETQFPgYSDFQIAENILSLVNNQANIWLGMF 963 
XP_019687352  499 CWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYwc--wdLESKFPeYGEFKIAENVLHLVYNQGMIWMGAF 576 
XP_014347310  628 CWETMVGQEFVRLTVSDTMTTYITILIGDFLRAVFVRFFNHCwc--wdLEYGFPsYSEFDISGNVLGLIFNQGMIWMGAF 705 
XP_022523557  580 CWETTVGIEFVKLTVSDIQVTYLTILIGDFLRAMIVRFLNYCwc--wdLEAGWPsYGEFDISGNVLGLVFNQGMIWMGAF 657 
XP_002710920  572 CWETAVGIEFMRLTVSDMLVTYITILVGDFLRACFVRFMNHCwc--wdLEAGFPsYAEFDISGNVLGLIFNQGMIWMGSF 649 
ELK04029      520 CWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCwc--wdLEAGF--------ANQVCGFCPSR----MGSF 585 
EEN49741      174 CWETIVGQEMYKLSVFDMIATLVTTIIVDFLRGLFVRFANYCwc--wdLEAKIPgYGEFGVAENVLHLIYNQGMIWMGAF 251 
XP_002007984 1038 CWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNwc--wdMEKTFPqYGDFKIAENILTLINNQGQVWMGIF 1115
CAP24545      481 CWETIIGQEIVKLVTMDLIFTILSILVIDFLRGLWIKYCSSWwc--wdIETTFPeYGEFKVAENVLHIINNQGMIWLGLF 558 
NP_001335566  294 CWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYwp--wdLERTFPeYGEFKVAENVLHLVNNQGMIWLGLF 371 

XP_015788900  964 FSPGLPGINTIRLCILMYLQSWAVLTSNIPHETVFKAS 1001
XP_019687352  577 FSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRAS 614 
XP_014347310  706 YAPCLPAINVLRLHTSMYLQCWAVMCCNVPHERVFKAS 743 
XP_022523557  658 YAPGLVGINVLRLLTSMYYQCWAVMACNVPHERVFKAS 695 
XP_002710920  650 YAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 687 
ELK04029      586 YAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 623 
EEN49741      252 FAPCLPVLNVLKLIALMYLRSWAVIMCNTPHQRVFRAS 289 
XP_002007984 1116 FSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKAS 1153
CAP24545      559 FAPLLPAINNIKLIILMYIRGWAVMTCNVPAREIFRAS 596 
NP_001335566  372 FVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRAS 409
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