2NTL


Conserved Protein Domain Family
IMP_cyclohyd

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pfam07826: IMP_cyclohyd 
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IMP cyclohydrolase-like protein
This enzyme is may catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily. A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family.
Statistics
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PSSM-Id: 429683
Aligned: 54 rows
Threshold Bit Score: 197.429
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NTL_B            22 YLGRILAVGRNsNGS-FVAYRVSSRSFPNRTTSIQEE---RVAVVPVEghERDVFRNPYIAYNCIRIV------GDTAVV 91  Methanother...
Q5JD29             3 YVGRTLGIGLN-NGKpFAFYLLCSRSFPNRRAVVKGN---GVYIL-----NQTETENPYVSYPVVRLM------EDYAVV 67  Thermococcu...
Q18DI6             2 YLGRFIIIGET-----TAVYRVSSRSYPNRQIISRDN---MLTVVPTSeaAQT--NNPYVSYNCMRQG------GEKIVI 65  Haloquadrat...
Q9HMV4             2 YIGRFVVVGPS-----VAAYRVSSRSFPNRKLIERPA---GLTVVPTAdaEET--TNPYVSYNCVRTA------GGHAVV 65  Halobacteri...
KHU:HacjB3_00690   2 YVGRFLIVGPD-----CGAYRVSSRSFPNRRIIERDD---RLTVGPTAdaEET--DNPYVSYNCVRSV------EGGAVL 65 
BFU:L593_10885     2 YVGRFVVVGPD-----VAAYRVSSRSFPNREIRDRDG---TLTVGPTDdaPPT--DNPYVEYNCLRTTdagprdGAAAVL 71 
jgi:Halru_3184     2 YVGRFVVVGPE-----TAAYRVSSRSFPNRQITDRSDedtTLTVGPTPdaPET--DNPYVAYNCLRTVet--prGEAAAI 72 
jgi:Halxa_1460     2 YVGRFVVVGPE-----VGAYRVSSRSFPNRKLTERED---ALTVGPTDdaPET--DNPYVSYNCLRVVet--ptGETAAF 69 
WP_014052656       2 YVGRFLVVAPG-----LAGYRVSSRSFPNRKAVERDG---AVTVLPTAeaEPT--DNPYVSYNCVQEVd-----ATTAVI 66  halophilic ...
Q5UZ65             2 YVGRFVVVSPE-----VGAYRVSSRSFPNRQAVQRDG---TVTVEPTPdaPET--DNPYISYNGVRVT------ERGAVV 65  Haloarcula ...
2NTL_B            92 SNGSHTDTIADKVALGMNLRDAiglsLLAMDYEKDELNTPRIAAAINGSe-----------AFIGIVTADGLMVSRVP-- 158 Methanother...
Q5JD29            68 TNGLHTDFIAQALEWERP-RKAlvhvLDALDYERDDYSTPRIAGIIQhgg---------rrGWLGFVGRDMLWMRELEle 137 Thermococcu...
Q18DI6            66 GNGSHVDPIAEKIDRGYPARDAlaeaLLALDYEKDDYNTPRIAGIVGSS------------SYVGIIRQDAVIIRSIS-- 131 Haloquadrat...
Q9HMV4            66 GNGSHVDPITEKVERGYPPRDAlteaLLAMDYEKDDYDTPRIAGVLAPDg----------tAYVGIVRADAVLVRAVE-- 133 Halobacteri...
KHU:HacjB3_00690  66 GNGSHVDPVAEKIELGYPARDAlatsLLALDYEKDEYDTPRIAGVLDGEe-----------AVIGIVRKDALLVERVT-- 132
BFU:L593_10885    72 GNGSQVDPILEKIELGYPARDAlaesLLALDYEKDDYDTPRLAGVLDEDg-----------AHVGIVRKDAVLVKRVE-- 138
jgi:Halru_3184    73 GNGSHVDPIAEKLELGYPARDAlataLLALDFEKDDYDTPRIAGVLDADg----------eATIATVRRDALLVERVD-- 140
jgi:Halxa_1460    70 GNGSHVDPIAEKLELGYPARDAltesLLALDYEKDDYDTPRIAATIGDDg----------eALIGTVRKDALLVETVD-- 137
WP_014052656      67 GNGSHVDPIAEKLGLGYPARDAlalsLLALDFEKDDYDTPRIAAVVGAEs-----------AFIGTVRRDALLIQEVD-- 133 halophilic ...
Q5UZ65            66 GNGSHVDPIAEKLELGYPARDAiaepLLSLDFEKDDYDTPRVAGIVGVDaadpttnadgpgAVIGTVRRDALLVEEVT-- 143 Haloarcula ...
2NTL_B           159 EETPVYISTYEQTEPAATEF--KAgSPEEAAEFILKggefAAFTHPVTAAAAFND 211 Methanothermobacter thermautotrophicus
Q5JD29           138 EGKAFLTATYNMEGFESIEL--AFsTPEELAEKVME----LPFEHKVLAIGIVEN 186 Thermococcus kodakarensis KOD1
Q18DI6           132 --EPTLVSTYENDAPTTAQLs-LKgDIEEIAQKAYE----LEYEHPVCAAAVTHQ 179 Haloquadratum walsbyi DSM 16790
Q9HMV4           134 --EPTLVATYEKDAPEAIGF--DAaTAADAAREAYS----AAFEHAVCAAGVSRR 180 Halobacterium salinarum NRC-1
KHU:HacjB3_00690 133 --EPTLVATYEKDSPEGIDF--APeSAAAAAETVYD----HEFEHAVCAAGIVRA 179
BFU:L593_10885   139 --EPTLVATYERDAPGPVEF--EAsAAAEAAAEAYD----FDFEHAVCAAGVARS 185
jgi:Halru_3184   141 --EPTLVATYERDTPGAFEF--DAtDAEAAAATAYD----LDFEHAVCAAGVTRD 187
jgi:Halxa_1460   138 --EPTLVATYEKNAPEAFDF--EAeTAEEAAREAYD----LEFEHAVCAAGVART 184
WP_014052656     134 --EPTLVATYEADSPEPFPFdsEPaDAAGIARALYE----HEYEHAVCAAGVTVD 182 halophilic archaeon DL31
Q5UZ65           144 --EPTLVATYEENSPTAFDL--AAtDASDVAREVYD----HEYEHAVCSAGVAGS 190 Haloarcula marismortui ATCC 43049
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