Conserved Protein Domain Family
N1221

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pfam07923: N1221 
N1221-like protein
The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome. This encodes an acidic polypeptide with several possible transmembrane regions.
Statistics
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PSSM-Id: 429737
Aligned: 86 rows
Threshold Bit Score: 172.043
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE02969       66 ITYDFTYEDMGDFDEEIDEWFPYQvsQW-VRLtYAQQ---YFESRWERVvsrgggnkaktggnnnyqpehnglnghnghs 141 
KDE05127      234 ytfpspppDSSDIVSELQEFYSYV--EVpQVI-DHKDsflAWWDRPQQA------------------------------- 279 
XP_006959818   25 tfMDFKYNDDDNVMNEINEFYSYL--DVrCIL-DGKH---EWLDADYGS------------------------------- 67  
XP_009267062   25 tfLDFDYTDDDTLPNELNEFYSYV--DVrSVL-DNKH---EWQVGECGS------------------------------- 67  
CCA68099       33 tfYDYHYDDEDSLFEEINEFYAFI--EAdQLA-ENLK---VWQGSFDGD------------------------------- 75  
EPT03705       37 SYYDFKYDDEDTVLNEIEEFYSYV--EMpQVA-ENLK---AWEGSFPEV------------------------------- 79  
XP_003038223   51 wYYDFNYDDEDNVMNEIEEFYSYV--EMpQAA-ENLR---AWEGSFDGD------------------------------- 93  
XP_001836913   45 SWYDFKYDDEDTVMNEIEEFYSYI--EMsQVA-ENLK---AWEGCFPSE------------------------------- 87  
EDR14179       20 SWYDFKYDDEDTVMNEIEEFYSYI--EMpQVA-ENLK---AWEGSFTTE------------------------------- 62  
EGO01707       47 SYYDFRYDDEDTVMNEIDEFYSYV--EMpQVA-ENLK---AWEGSFPGE------------------------------- 89  
EPE02969      142 gangynynggddgysddeqfeerpWDTV--DAETQSDFVTGVLRSLESG-KAReRPEVVGCLVYLLLGRWGAttggpfpg 218 
KDE05127      280 ------------------------FIDV--PQTEQIELIHSLLDGLASPdPDA-RFTVARHLLYIAQGTFES-------- 324 
XP_006959818   68 ------------------------WWAM--EDSQRRDLLAKLLNAINGDkLSE-RLKASRKLLYVMQGSFIE-------- 112 
XP_009267062   68 ------------------------WRDK--PLDHRQSLIKDLLSAINADkLSE-RLRASRKLLYLFQGTFSE-------- 112 
CCA68099       76 ------------------------WTKA--PLQQRKTHVVALLEDLEHKdSLT-RYNASRRLLYLLQGAFAE-------- 120 
EPT03705       80 ------------------------WIES--SFAHRKAHVEVLLESLEHRdAEI-RFTNARRLLYVLQGTFAE-------- 124 
XP_003038223   94 ------------------------WLSS--TPEQRKTHVEFLLESLEHKdPEI-RFTNARRLFYILQGTFRE-------- 138 
XP_001836913   88 ------------------------WTKA--PLNQRRSHAERLLEGLEHRdAEI-RFTNARRLFYVLQGTFAE-------- 132 
EDR14179       63 ------------------------WTKA--PIALRKSHIELLLESLEHRdAEI-RFTNARRLFYVLQGTFSE-------- 107 
EGO01707       90 ------------------------WTNSdtTPAQRKAHVEVLLESLEHRdAEI-RFTNARRLFYVLQGTFAE-------- 136 
EPE02969      219 skrspkarTVARQRQLDAMKSSAALVGKVGGIPVIWNALRKAFEPFWGPD--DVQQLPT--------------------G 276 
KDE05127      325 --------STSPDHHLELIQANCALLRNAKALDAIWDAVKKTGERWERVShlPNTNPGSndpsssagagesqplnivefE 396 
XP_006959818  113 --------SKSTKHHLDCIIENVKLVRECGGLNKIASALRAAISFHs----iVHTDYAHl------------------aE 162 
XP_009267062  113 --------ARNSRHQLECIIDNVHLIRLCGGLQSVTQALQAAVSFHa----vVHSEYAHl------------------aE 162 
CCA68099      121 --------STSPEYQMHWIIENAKLVRASQGITIIVDALKMLSVKHDQLAtiADADLARina--------------aphM 178 
EPT03705      125 --------TTSAEHQLHWIFENCKVVRSANGLSNIVEAIKIASSKHDLLCslSDADTARfni--------------saqE 182 
XP_003038223  139 --------TTSPEHQLHWIFENCKVVRGANGVSTIVEAMKIAQSKHDFLCglQDQDLEHfni--------------svqD 196 
XP_001836913  133 --------TVSPEHQLHWIFENGKLVRSANGISNVVEALKIAGRKHDLLSnlSDQDAAHfhi--------------svqD 190 
EDR14179      108 --------TVSPEHQLHWIFENCKVVRSANGVSSIIEAMKIASHKHDLLYnlSDQDAAHfhi--------------saqE 165 
EGO01707      137 --------TTSPEHQLHWIYENCKVVRSANGLSTIVESMKIASQKHDLLCslSDADAAHyhi--------------tpaE 194 
EPE02969      277 l----lQDAQD---ELANLMTVFYVLVQATLSdpldMAACYVKLVELQPPIPDFMMNVASRLRWDDNPVIPQCQVFLLLW 349 
KDE05127      397 eaqhrqEQLDEinsELALLLAVLYFMMEVHRG----DDDWAEELMQLDPPAPIYLFNLVAGLRERNAKGYPVKKLLLLLW 472 
XP_006959818  163 p-----DFIEQvnvELGSYMEMLYYMVQILRH----DSTFADELMNLEPSLPTYLFTLLSGLRDKTAKGYPVKKLLLLLW 233 
XP_009267062  163 p-----DFVEQlniELGGYMEMLYYMVQILRD----DNSFAEDLMHLDPSLPTYLFSLLSGLRDKTAKGYPVKKLLLLLW 233 
CCA68099      179 r----qSWIDEvqaEIAMCLNMLYPIIEVFRS----DDEFAEELMGMEPPLPIYFLSLLSTLGNRSAKSYPAKKLLLITW 250 
EPT03705      183 k----aDFMEEvttELSVYLAMLYHMVEVFKG----HDDFADELMSLEPPLPVYLFNVVAGLRDKSAKGYPVKKLLLVLW 254 
XP_003038223  197 k----nDLVEEvttEISVYLGMIYHIVEVFKG----HEDFADELMSLDPPLPVYLCNVVASLRDKSNKGYPIKKLLLVCW 268 
XP_001836913  191 k----tDLLEEvltEISVYLGMLYHLIEVFKG----HEDFADELMSLDPPLPVYLFNLVAGLRDKSAKGYPIKKLLLVLW 262 
EDR14179      166 k----aDFIEEvltEISVYLGMLYHLIEVFKG----HDDFADELMSLDPPLPVYLFNVVAGLREKTAKGYPIKKLLLVLW 237 
EGO01707      195 k----sDFLEEvttEISVYLGMMYHLIEVFKE----RDDFADELMSMDPPLPVYLFNVVSGLKDKSAKGYPIKKLLLVLW 266 
EPE02969      350 KSLLLSFGGTRELVETKKATAEs---tADVDKEK-NL--------------------------------IMASPLDYHAF 393 
KDE05127      473 KSILACIGGQSDIPRVRALVRSieglePNPSRPRtPApqtrpfppssssstcdvpssptdsviadvkphTKVAPTDFVAF 552 
XP_006959818  234 KTLLVVFGGWEDIDCLKDISYElfkcnLAVKDDNtI---------------------------------LKSNPLDLQQF 280 
XP_009267062  234 KTLLVVLGGWKDIDRIKELSYDlfscsLATKDDNtI---------------------------------VKSNPVDLQQF 280 
CCA68099      251 KVLLACLGGMNEQARAKAVARElaglpPLTEASLm----------------------------------LKATPVDLQTF 296 
EPT03705      255 KTLLTCCGGIREIARVKNLARElaglpPVPEEAIp----------------------------------IKASPLDIEAF 300 
XP_003038223  269 KTLLACCGGIRDHARVKTLARElaglpELPEEKMp----------------------------------IKSAPEDIEQF 314 
XP_001836913  263 KTLLACWGGMKDHERVKKIARElag-lpNSEGPDk----------------------------------IKSTPLDIEQF 307 
EDR14179      238 KTLLTCWGGIREYERAKRLTRElsg-lpVGESGDr----------------------------------IKSTPIDIETF 282 
EGO01707      267 KTILACCGGVRELARAKVVARElanlpLIPNEAIp----------------------------------IKCSPVDIETF 312 
EPE02969      394 RHEITSKYPAYI----PPQPLLPL 413 
KDE05127      553 NSEITSKYPSYI----PPPLPIKL 572 
XP_006959818  281 YSQTSLKYPTYR----PKQQSLPL 300 
XP_009267062  281 FTQTSLKYPTYK----PNAQPLPL 300 
CCA68099      297 REETFVKYPTFS----PPPIteaa 316 
EPT03705      301 RSEISVKYPTFI----PPPAPVPV 320 
XP_003038223  315 HQETTVKYPTFQ----PQPVQAPi 334 
XP_001836913  308 RQETAVKYPTFT----PPPHPpps 327 
EDR14179      283 RHETFVKYPTFTaaqqPPPQvaea 306 
EGO01707      313 RQETSVKYPTFT----PLPPPsrp 332 
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