Conserved Protein Domain Family
PIG-X

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pfam08320: PIG-X 
PIG-X / PBN1
Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.
Statistics
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PSSM-Id: 462426
Aligned: 93 rows
Threshold Bit Score: 109.753
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDN04722      55 PTGLHPTLQISIp----rSSLSEPpprappDSKCSLHTYLTLPSSLFADKYQLSttDPLFlqshnllS--LRAIAGETDL 128
XP_003290025 366 KSGFHRELVSNVtiksppTLKIP--------RECKLLFLEHFDQGIFVDRYEVDeiER-F-------GgpKVNIYQLIDL 429
XP_015460534  44 KKGFHRELLYEVk-----HDPTP--------HVIKTLLIQRLPSGVYMDQYQLAslKEDT-------Gl-EVLLDSSVNL 102
NP_001119908  43 KAGFHRDLEYSVyws-------------etdHDVKALLVQKMPSGVYMDEYQLEtlRH-D-------TglEVLLDSKVDL 101
Q4RKZ7        47 KKGFHRQVETTVelslgvL------------TGVQVMLLYRWPRGVYLDPYQIAslHK-Q-------SnwKILIDSATDL 106 spotted green p...
XP_003439965  49 KKGFHREVTTTVefrskeL------------CGVKVLLIHRWPRDVYVDPYQLAslSD-Q-------NkwKILLDSPIDL 108
XP_002109521  68 lEGFHRDLITKInfrsevKSNLTSf-----SDQCSLLLVERLPTGIYVDLDQVAemERLL-------KdiSVISSDRIDV 135
EEN55339      75 NHGFHRDVVTEVtlpvamVTPP---------MSCRLLLVETVPAGMYVDLHQVTfrTD-F-------GgpQVLALSDIDV 137
XP_015216555  45 KNGFHRELVTSV-----------Ccgl-gsPKNLHFLLVERLPKGIYIDPYQLTseQH-D-------TglQVLLDTEIDV 104 spotted gar
XP_014352359  47 KDGFHRELLIDVeaggaaGVP----------EGCSLALVVHLPKGVYVDPYQLAmlKE-S-------NelEALVLNEVDV 108 coelacanth
EDN04722     129 EAPDWVTDRWgsSLLLELATplsrpsrkhkttyvngnhndDNDDYDEDDWQITIPLHLRYLHP-S--PSGYRNISVPWPV 205
XP_003290025 430 EKPSATSTQN--YISVvk--------------------efTVNSEPEQTIQVTLPIHLRYQNPiNsnQDAYRNTHISSPM 487
XP_015460534 103 EDPAYVSPGF--SALVYLRP-------------------------AERVLQAAVPIHGRYHRPs--nSGGWEKVTIEGPK 153
NP_001119908 102 EAPEYLSSGF--TALV-----------------------------FLSGNAVTVPVHGRYHRPs--dTHSHVTVDIQPPR 148
Q4RKZ7       107 ESPAHKTRGF--VTYVy----------------------pIPEGPTAR-IKVTIPIHGRYHEP-SfeGKTFTSVHIEPPD 160 spotted green p...
XP_003439965 109 EVPAHEASGF--VTYVy----------------------pFSTGPTSKLFKVTIPIHGRYHKP-SfdGKMFKSVDIEAPE 163
XP_002109521 136 EKPAHLSTEH--LLLVya---------------------rINPITDVRSTKVSLPIHLRYHLP-QddWYGYTEVVMPRPM 191
EEN55339     138 EQAAHQSSHH--RLLLys---------------------pLQQNPKGFTWRVTLPVHLRYHRWaGegEDTSATVRLEGPD 194
XP_015216555 105 EAPAYVSSAF--PALVy----------------------pTRDPASPVCLKAVVPIHGRYHRP-SdsGKRTAPIDIENPH 159 spotted gar
XP_014352359 109 EAPEYFSSEV--SVLVf----------------------tKRSSQCIGCFTSTLPLHARYHRP-StgGETHVTVILGNPQ 163 coelacanth
EDN04722     206 V-FWAC--APEDggege----taggGKTMGINPFDRVGLGwdglfapGTLFYQLHPDTAASatgvdaha---lveqrglM 275
XP_003290025 488 I-FIQCepTNSV--------------------------------------------TESKStfdhwklitsfsplfehtK 522
XP_015460534 154 L-LLRPekYETKtlp-------adlPHRVVKAPCTVRNQS-------LCSWLEIQTSLVSDs------------------ 200
NP_001119908 149 L-LLRSdqCTSIlistdsegetpnaQHTVVEAPCTFRNEsf-------clWLEIQDLKGSAg------------------ 202
Q4RKZ7       161 L-LLRAenCPSFss---------fkPHNVISAPCRADNSst-------csWVKGHSHKEPGs------------------ 205 spotted green p...
XP_003439965 164 L-LLRTekCAQLss---------lePHTVVDAPCTASNSst-------csWVKVKPQQDLNp------------------ 208
XP_002109521 192 LiLIHCdkELPEf-----------qCQPKYTAPCSNSNKss-------cvWNLLYDNENEDs----------------gN 237
EEN55339     195 V-LMHCegDRPVttp--------ceESRLFPAPCDAESRgv-------clWQLLKGKAEP-------------------- 238
XP_015216555 160 L-LLRAdsCdlpp---------nfiPYTLTDAPCTALNHsm-------crWLQIHSAQEPGp------------------ 204 spotted gar
XP_014352359 164 L-MTRCqtVPVDle---------cpESVVKEAACTAENKts-------cnWLLVNYKHVSEg------------------ 208 coelacanth
EDN04722     276 VEKIQVPVLKIGdggglseDVHSIETVTLIVVCFGFLWVFRSL 318
XP_003290025 523 SLFIDVPVGQLK-------DLESVKFNTLTVTVIGSILVIATI 558
XP_015460534 201 -vSLKLPVGNLS-------LAGPVCAGTVLATLLCCALLFRSV 235
NP_001119908 203 -vSLELPVGDSS-------KTTCVCVVTLLTTTLCCVYLLIVI 237
Q4RKZ7       206 vSSFQLPVGDGR-------LLMPVSAGTLLVTLICCLLLSKYM 241 spotted green pufferfish
XP_003439965 209 -vSFQLPVGDGS-------LVAHVCGGTLLVTMICCVALSKYM 243
XP_002109521 238 EIILKVPVGIVK-------HGVLVSIGTIISAIAGTIILIIAI 273
EEN55339     239 -LLFQVPIGQQS-------HAVLVITGTTAVAALGSLLILVAa 273
XP_015216555 205 -lRLEIPVGDMR-------LVGLVSAATLLVTLLSCGYLAGAV 239 spotted gar
XP_014352359 209 -aAMEIPVGQER-------RVVVVAAGTLLVTTLCCGLVLGAV 243 coelacanth
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