Conserved Protein Domain Family
WLM
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pfam08325: WLM 
WLM domain
This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation.
Links
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Statistics
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PSSM-Id: 311984
Aligned: 18 rows
Threshold Bit Score: 209.882
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6CDQ4    121 PAPSEYCFDKivplDWlPEKERALELLTRLSKDrgVIAVLQKYKWRIGVLTELDPASNTnsdhqgterLLGLNRNKGQVI 200 Yarrowia lipolytica
Q6ZK12    139 FCDFRTLHLPgi-eLN-PPPSEALKRMHMLACDpgIIAIMNKHRWRVGIMTEMAPVGYVgvs---pkcILGFNKNMGEEI 213 Japanese rice
Q8VYQ7    144 FGDFRTLQLPgi-eLN-PPPSAALKRMHMLAADpgIIAVMNKHRWRVGIMTELAPVGYVgvs---prcLLGFNKNQGEEI 218 thale cress
EAA34387  181 ftfQTIRPLP----HL-PNPSRSLSFLNRLASDpgIRAAMRSHQFTVGLLTEMDPGQYTasnhegttrILGLNRNKGEVI 255
Q5BEI1    137 SNNYTFHTLKpl-pYL-PNPARSLQFLTRLRDDpgIRSAMAKHRFSVPLLTEMDPAEHTtse----srTLGLNRNKGEVI 210 Aspergillus nidulans
XP_752634 137 ntytfhrlLPl--sYL-PNPSRSLEFLARLRDDpgIRAAMAKHRFSVPLLTEMDPAEHTtse----srTLGLNRNKGEVI 209
Q8IJV0     11 YKVHNIKVLN-------KNDKKAKAILSRAAEQ--VLPIMKKRRFRVELLSEFLPKNPN---------LLGLNIVKKSEI 72  Plasmodium falcipa...
Q5AEH7     18 PPPANIKKIGal-kRF-SDEAYAKSLLYDAARL--VAPIIHEQKFKVGKLYEMYPDKAE---------LWGLNVNHGQKI 84  Candida albicans
Q6FT16      4 PHIRNIAVLQ----RK-PGKEDALKLLKDIADA--VSLLMRENKFKVGTLVEFYPRDRS---------LLGMNVNHGQKI 67  [Candida] glabrata
P38838     27 PHIQKVAVLQ----SK-PNKEDALNLIKEIAHK--VSYLMKENHFKVTNLVEFYPRDQR---------LLGMNVNHGSKI 90  Saccharomyces cere...

Q6CDQ4    201 ELRLRTDNY-QGWRNYYNVRNVLCHELAHNVYSDHDDQFWRLCKLLEKEVVELDP----------FGKEGNTVGGTAVST 269 Yarrowia lipolytica
Q6ZK12    214 SLRLRTDDL-KGFRKYESIKRTLLHELAHMVHSEHDANFFALNKQLNDEAASLDWt----------KSRGHVLSGRKIFD 282 Japanese rice
Q8VYQ7    219 SLRLRTDDL-KGFRKYQSIKKTLLHELAHMVYTEHDEKFYALDSQLNKEAESLDWt----------KSRGHTLNGTKFIN 287 thale cress
EAA34387  256 ELRLRTDAY-DGYRDYKTIRKTLCHELAHNVHGDHDRQFWDLCKQIEREVERADY-----------TKNGRVVGGAEYEY 323
Q5BEI1    211 ELRLRTDAY-DGYRDYRTIRRTLCHELAHCVFSDHDRDFWDLTKQIEGEVERGDY-----------RSGGRMAGGDEFYN 278 Aspergillus nidulans
XP_752634 210 ELRLRTDAY-DGYRDYRTIRKTLCHELAHCVFSEHDRDFWDLTAQIEKEVERADW-----------KHGGRRLTDEEFYN 277
Q8IJV0     73 KIRLRKTKG-GEIFHFNDIMGTLLHELVHIVHSRHDKSFYELLDKITWEYNELYV----------YNKKGISGGDKVSTN 141 Plasmodium falcipa...
Q5AEH7     85 YLRLREHHNdKSFLPMGDIVGTLLHELTHNLYSAHDSKFYKFLDKLKSRYDDIHCrgaktkylceENKVGRGVLLSGSLV 164 Candida albicans
Q6FT16     68 MLRLRDPLDeFRFLPWESLIGTMLHELTHNLHGPHDQKFYSKLDELSGRQWCIQQlgl----kdnFMTSGNRLGGRGFRD 143 [Candida] glabrata
P38838     91 MLRLRCSTDeFQFLPMECIMGTMLHELTHNLFGPHDKKFYNKLDELIGRQWVIEQrgl----ydtFLGNGQRLGGRANLR 166 Saccharomyces cere...

Q6CDQ4    270 TSGpyq--ewlEMDSDEDVGDSGGWHGGTYVLGrGRNEvqq--ekeDKNKSIRELLQRAAERRQQ 330 Yarrowia lipolytica
Q6ZK12    283 S-------------YEDEFVLEPDSVVVGHKLG-GGS---------SSLASARVLSGSAAYKRFL 324 Japanese rice
Q8VYQ7    288 D-------------DDEEDYFFDENETVSQRLG-GNQS--------DNLGNARESSVAAAYRRLS 330 thale cress
EAA34387  324 GPApvnespdeGEEEEGMVMDHGGWTGGTYVLG-ASDAvpsstsaeSAGLTRREILAKAAEERMK 387
Q5BEI1    279 PSDw------eVEREGGHVVDGGGVVGSSQVLG-GNSQv------gASGGGMREVLARAAEERAR 330 Aspergillus nidulans
XP_752634 278 PGDw-------EREKDAAVVDERGWTGGEFVLG-GLRDe------sSGVESRREIIARAAEERMR 328
Q8IJV0    142 I--------------IKYNLGRNNIMKDNIILD-ITKMnnv---isICEENPKFMAAQAAEKRLL 188 Plasmodium falciparum 3D7
Q5AEH7    165 SV----------REQRLKELSKPKFANESKVLG-SNSKink--pigGSPRDLRQAILEAAERRLR 216 Candida albicans
Q6FT16    144 GPT--------PRTTNSRGNKIEKIRNKGVRLG-SLSDnlngslntSRMLKPAQMAAMAATRRAE 199 [Candida] glabrata
P38838    167 SNRy-------PMTGISTNTGIVRKRGKGVKLG-SLHPegi--ssiDRGNSPRELAAFAAERRYR 221 Saccharomyces cerevisiae S288C
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