4BT8


Conserved Protein Domain Family
P4Ha_N

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pfam08336: P4Ha_N 
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Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.
Statistics
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PSSM-Id: 311993
View PSSM: pfam08336
Aligned: 190 rows
Threshold Bit Score: 79.2288
Threshold Setting Gi: 1028717499
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BT8_A          8 SIGQMTDLIHTEKDLVTSLKDYIKAE---EDKLEQIKKWAEKLdrlT----ST--ATKDPEG-----FVGHPVNAFKLMK 73
gi 121992172    1 MTKVFGYEQKMLQHMQKFVADNQSKL---DFLRARLREFEQERteaQ----HW--GTAYFES-----PLNQYLLSKRLTV 66
gi 260806889   27 ATVHMEGLVWVESEMARAVRNYVRLGglvPPELQRLAEGAAWLsdpTqvdpNS--------------LVYNPIGAYLLIK 92
gi 733875994  105 ALRSVRQARGNEGRLLRRLRAYLREE---SARLRRLSRFYEKVralH----QDpgA-----------SVDNPLLAFSLIK 166
gi 674591277   26 SLVDISQAVVAGRHLSRELTSFLNKE---ESRLAKLREVILRLdsaLeifnVSdpNQVSLPSie-neAAANPISAFLAII 101
gi 196011902   30 ATDDIEKLIYSEYELYHELDNYIKLQ---QNRLVTLRKLLDEIksqMhgvhLK--GYEQGKH---------PLAVFLLVR 95
gi 156352046   21 SLEKMKGLARLESFLPTILEKYLDRQ---QVIPRVLLDFLDLLktqT----------RVKNDmgldrFVLHPTNAFKMIR 87
gi 156352054   24 ALTHMRGLIRLEKTLQRKLVEYLNLN---PRASEDLRITMEEVkqhT----KN--IRGDVEK-----FLGHPVNAYMLIR 89
gi 1028717499  24 sqiMLTKLYDVQNDHFNVLDNYANLE---TKRLEELKNYVAAVyewR----DNikTKKQ--------FLHDHMDVFKVMT 88
gi 156370133   13 SMDQLQRLSTVEKNLHETLDLYIMQE---RKRLEDLKGIYAAKkeeL--------KKRERDD-----EVYHPLDVFRVIN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BT8_A         74 RLNTEW-SELENLV-------LkdMSDGfISNL-T-------------IQRQY----FPNDE--DQVG------AAKALL 119
gi 121992172   67 DWRRVQ-NLMYADT-------GekPLERlLKLR-Q---------------RPSmpdaSELEG--AIDG------LLRLQY 114
gi 260806889   93 RLNQEWaNAIKTLP-------QpqEVFGeLYDElQ----------------------LPSLA--DLEG------CALALM 135
gi 733875994  167 RLSSDW----PSVV-------YssEATEnSRAL-H-------------VGFQElqreLPGAE--DLDG------AARALM 213
gi 674591277  102 RLAANWsSELSVILgfpnvdpDkvDSISyKDTS-MgvynefdsrrklfLRLKWyanmLPDDR--DVRG------ALDAVI 172
gi 196011902   96 RFLRNW-KELEATA-------EeeQIFN-DKLL-D-------------TFAYYkr-tFPNLQ--DLEG------SAEAIL 143
gi 156352046   88 RFLKHW-TELANYL-------NkgPDNDlKEML------------------NVnrpiFPKPS--DLLA------CAEAIL 133
gi 156352054   90 RFIKNW-KDVEEYL-------EkhDDQ--EDLL---------------ALLRLhkvdFPTSK--DMLG------CVQAIQ 136
gi 1028717499  89 QMLQHY-FQIDDLI-------KnkKSLEaFKDI---------------------------DEhkDLSGehivllAHRALR 133
gi 156370133   77 RVSSEW-STVEKLV-------RfnPHKS--EFI-Q-------------EIRNYha-sFPSDA--DFDG------TRAAML 123
                         170
                  ....*....|....*...
4BT8_A        120 RLQDTYNLDTDTISKGNL 137
gi 121992172  115 VYRLEAKHLAKGILDGVN 132
gi 260806889  136 RLQDVYNLDMRRIIDGEI 153
gi 733875994  214 RLQDVYALSVKGMANGLF 231
gi 674591277  173 RLQQTYNIPSIEIAEGRI 190
gi 196011902  144 RLQDVYNLKEIDLASGII 161
gi 156352046  134 RIQDVYNLTAKQIAKGHI 151
gi 156352054  137 RIQDVYNITAKRIASGHL 154
gi 1028717499 134 RLQLFYAIPASDMSAGRF 151
gi 156370133  124 RLQKVYNISSQSISSGVI 141
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