4M8N


Conserved Protein Domain Family
Plexin_cytopl

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pfam08337: Plexin_cytopl 
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Plexin cytoplasmic RasGAP domain
This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Statistics
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PSSM-Id: 462434
Aligned: 44 rows
Threshold Bit Score: 592.634
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4M8N_A         47 AIPFLDYKHFASRIFF------------------------PE------------Agtltavm--irdigeDSEQTTVDE- 87   zebrafish
6_pfamImport    1 GIPFLEYKHFVTRTFF------------------------PKaggspfspkssaPgk------------qSGCRPNMEE- 43  
EGW12632       32 GIPFLEYKHFVTRTFFpkcsslyeekyvlpsqtlnsqgssPPqethpllgewniP---------------EHCRPSMEE- 95  
BAG58219       59 TVPFLDYKHFALRTFF------------------------PE------------Sggfthi---ftedmhNRDANDKNE- 98  
XP_015207788  946 TIPYLDYKHFAVRTFF------------------------PE------------Ampalssi--vndvgqDMEKGKQNE- 986 
EGD75945     1444 eahprpfGEYARRVYF------------------------TAldthplpvrprfPgt------------nD--------- 1478
EKC27333      182 GIPYHSYQSYTQYILF------------------------PKeveaatia--------------sllehsgFSSKNAEK- 222 
O45657       1194 GPELINFPHFVENLLWsdnnlt--------------------------sapslaRtl------------pV--------- 1226 Caenorhabditi...
XP_018671834 1290 riiylppwEYITQVLF------------------------NQrsghpv-----------------ldenamVGQGTVKQd 1328 vase tunicate
XP_016849234  952 TVPFLDYKHFVLRTFF------------------------PE------------PganafifiedsnephRRNPDQKDE- 994  green anole
4M8N_A         88 KCLAFAELIRDKQFLSCFVHALEEQK-NFSIKDKCTVASLLTLALHGDLLYLTEIMEDLLQSLMDQSSnAN--PKLLLRR 164  zebrafish
6_pfamImport   44 GISLFSTLLNNKHFLIIFVHALEQQK-DFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASA-SKn-PKLMLRR 120 
EGW12632       96 GISLFSSLLNNKHFLIIFVHALEQQK-DFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASA-AKn-PKLMLRR 172 
BAG58219       99 SLTALDALICNKSFLVTVIHTLEKQK-NFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSnMQ--PKLMLRR 175 
XP_015207788  987 SSQALSNLIHEQLFLITLVHTLEEQK-KFTIKDKCVFASLLTIALHSDLVYLTRVMEVLLRALMDQSSnTQ--PKLMLRR 1063
EGD75945     1479 CIEQFTFFLQQDDFLRAFVGVMEGEGrAFSVRDRCQVASLLMCSANGDEAMGTHTLSTLLDQYFTAn--SRrdPRLMLRR 1556
EKC27333      223 AMDQFDKLMSNKYFVKSLIGTLEKQR-KITLSDKAQFAANFSVIMMGKMRDFFEIVNCLLSTLVDSAN--KkqHKTLFNR 299 
O45657       1227 TLAQFHALLSFKGFIFTIVEAAESDV-SISTSEKSMLASLLISVLLRNFSYCTEVVVDLLRAHIARSVqNKr-AELLFRN 1304 Caenorhabditi...
XP_018671834 1329 ALKSLLSVIKNKDVLLVLVRTLEEQR-KFTVQEKGNMASLLTICLFDDLPYYTRVMLELLTGLIQKHV-SRn-PKLLLRR 1405 vase tunicate
XP_016849234  995 IITKLSKLICNKKFLVSLIHTLEKQK-TFSVKDrCLFASFLTIALQTNLVYLTDILELLTRDLMDQSSnIQ--PKLLLRR 1071 green anole
4M8N_A        165 TESIVEKLLTNWMSICLYGFL-RESVGQPLFLLVSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFEPLKLKVVFAv 243  zebrafish
6_pfamImport  121 TESVVEKMLTNWMSICMYSYL-RETVGEPFFLLICAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRTVSSWRDs 199 
EGW12632      173 TESVVEKMLTNWMSICMYGCL-RETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLNVSFQg 251 
BAG58219      176 TESVVEKLLTNWMSVCLSGFL-RETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEk 254 
XP_015207788 1064 TESIVEKLLTNWMSICLYGFL-RESVGEPLFLMVSALTQRINKGPVDAITEKALYTLNEDWLLWQAHDFHTLKLKVLFQa 1142
EGD75945     1557 TESVAEKLLTAWLTTGMHDAV-LRDAARPLYNLTQALKIYAWKGPVDAVTGAATYTLNADALLRERVEYEPLTLHVDM-- 1633
EKC27333      300 FESISLRLLSHWLSVSLYPYL-KEGGGSSLFMLYKSTQTVVEKRPVDEVTGEAKNTLSEDNFLREKIDCLTMKLEIDLNg 378 
O45657       1305 SDSVVEKMFSKWMSICLYSHL--TPQMNSYFYLYKALQYQTDKGPVDAVTGDARYTINEAKLLRESVDTKTLKIRVIPFe 1382 Caenorhabditi...
XP_018671834 1406 SESVVEKMVSHWLSINLYDECiNEQAGKPLFLLTKAVHYLVSSAPCDVIAKKAFNSLNEMTLLGTELQYETVVLHATIVe 1485 vase tunicate
XP_016849234 1072 TESVVEKLLTNWMSVCLSTFL-RETVGEGFYLLVTTLNQGIMKGPVDVITCKALYTLNEDWLLWQVTDFKTVILNVVFEn 1150 green anole
4M8N_A        244 gt----geeISESL--EVIALTCDTIQQVKEKILQTFQRKFGFRYTQQIRDIEI-----Ey-EKE-GKFVMLQEVDDTSE 310  zebrafish
6_pfamImport  200 wagaapgphSSPRCpgHIP-LSAGSAPQEPPLPLGCSQKQVPASRLPA----QLcpphtEw-FATsTDSYILRDLDDTSV 273 
EGW12632      252 --------cGMDSL--SVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDL-----Ew-FASsTQSYVLRDLDDTSV 315 
BAG58219      255 ipen-esadVCRNI--SVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGL-----El-QMG-TRQKELLDIDSSS- 323 
XP_015207788 1143 lpd--gekeAGATL--EVSVLDCDTTEQAKEKILRSFKSKFGYPYHVQLKDIDI-----Ey-EKE-GSVLKLQEVDSTSK 1211
EGD75945     1634 ---------NRQVY--EVHVNSCDTIGQILEKL-----KLVVTTAGADVSDFDTrvlvlQr-EEG---LRVLKDIDDSSK 1693
EKC27333      379 ---------NGNLY--TCEVLDCDTINQVKSKCLYQIYKNKPASEMPSTDEVDL-----Ew-MAGkSGRLTLSNIDQTSE 441 
O45657       1383 --------kCDESI--DLEVHACDAICQVKQKVASAVYRETPYSQRPRITQFEL-----Ky-KCPkRGDVKLTDVLPIET 1446 Caenorhabditi...
XP_018671834 1486 eg-----gkVTTSV--DVKVVNVDSIKQAKTKIIEAVYKDKPYSECPKPDDLDF-----AlmNSSeSTGITLSDVDGMSV 1553 vase tunicate
XP_016849234 1151 iqen-esegITKNI--EVSVLDCDTIGQAKEKILQAFLSKNGSLYGLQLSEMGL-----Al-QSG-AYTKELLDVDSSS- 1219 green anole
4M8N_A        311 IRGH--VTMLNTLKHYQVGDGACI----KVITPkihaplktqns--------------------------vkddknfsik 358  zebrafish
6_pfamImport  274 VEDG--RKKLNTLAHYKIPEGASL----AMSLSvwllsvlrrstlqrlpi--------------nsnsrsvvtgarkala 333 
EGW12632      316 VEDG--RKKLNTLAHYKIPEGASL----AMSLTdkkdntlgr------------------------------vkdldtek 359 
BAG58219      324 VILEdgITKLNTIGHYEISNGSTI----KVFKKianftsd----------------------------------veysdd 365 
XP_015207788 1212 V-GEngVKRLNTIGHYQLSDGDSV----RVTKKiaratlstqes--------------------------ikdddnystk 1260
EGD75945     1694 MSAG--WVQLNTASFYGMRDGDQL----AFVKSdtdggdarrrrnnnssssggggggggggslfkvrtksksridpmace 1767
EKC27333      442 RGDG--MVRRNTLKHYHVLDNSRM----ALLYKfspdvehddeddtyvnqrspsdvditippnvqliqsvsstgslenlr 515 
O45657       1447 LSQKklPVKLFTLADYGISDGCTLemspAVYTAesyrnsladsgqssw------------------ssldrcspiysssk 1508 Caenorhabditi...
XP_018671834 1554 VDGK--YTKINTLKHYNVPDNAVV----VLRPHdvenqapqdv----------------------------sspllppkh 1599 vase tunicate
XP_016849234 1220 VTLEdgITKLNTIGHYEIFNEATI----KVFKKektvlsgc-------------------------------sdeeysda 1264 green anole
4M8N_A        359 YFHLVDp---DID-TDLsnhp-------------------ekkALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLpNNK 415  zebrafish
6_pfamImport  334 LWDIIKnyqePQL-QPHrstsqrp-------------erqshrKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIrDDK 399 
EGW12632      360 YFHLVL----PTD-ELVepkksh---------------rqshrKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIrEDK 419 
BAG58219      366 HCHLILp---DSE-AFQdvqgkr---------------hrgkhKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLpNSR 426 
XP_015207788 1261 YCHLIEadgpEID-DLQkgnp-------------------qrkKLKLKEVYLTKLLSSKVAVHSFVENLFKTIWGLpNGK 1320
EGD75945     1768 PWHLVK----PDT-DGTaaaa------------------aaaaTRVPSEIFLTYLMTVKTALQPFVDDLVDAVFNI--DQ 1822
EKC27333      516 QWHLVK----NIE-EEDshek------------------psklKDIGKTSHITNLMHTKLVLQDNIKEVFDSVLN--HET 570 
O45657       1509 YYHLTN----PSSgTMTfkkkss--------------ndsnllPKSIPEVYLTRLLTSKGTVETYVEDFLESVLYMhDSS 1570 Caenorhabditi...
XP_018671834 1600 MYHLIN--------PSEeeqsngytdvqsdagkkademldnlmKRPFQEMFLTRMVKAKTTIQEYVDGVFNSILR--PKP 1669 vase tunicate
XP_016849234 1265 YCHLILp---DSE-AVKdvqgtk---------------hkgkqKFKVKEMYLTKLLSTKIAVHSVVEKLFRSIWTLpNNK 1325 green anole
4M8N_A        416 APLAVKYFFDFLDEQAERKKITDPDVLHIWKTNSLPLRFWVNILKNPDFVFsDMEKSPHLDGCLSVIAQAFMDSFSLTDT 495  zebrafish
6_pfamImport  400 PPVAVKYFFDFLEEQAEKRGITDPDTMHIWKTNSLPLRFWVNILKNPQFVF-DIDKTDHIDACLSVIAQAFIDACSLSDL 478 
EGW12632      420 PPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVF-DIEKTDHIDACLSVIAQAFIDACSISDL 498 
BAG58219      427 APFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVF-DIKKTPHIDGCLSVIAQAFMDAFSLTEQ 505 
XP_015207788 1321 APLAVKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVF-DMEKTAHLDSCLSVIAQAFMDSFSLAEQ 1399
EGD75945     1823 PSPAVRFLFHFLDDQARKHNISDPRTTHIWKSNAFPLRFWINLIKNPDFLL-HVQQTRTVSSGLSTVAQVIMDSCSVSDQ 1901
EKC27333      571 VPLVVHYLFGVLENLANKNSV-EPDTLLCWKSESYAMRVWATLLVRPEFLF-DIQKARHVEPCLNVIKQVFIDCFHST-- 646 
O45657       1571 YPPILKFFFDILDREASVNGVSE-NICQQWKANGYVLRVWANFVRNPQLVF-DVPHSISMDANLSTVAQTMMDCFSFSEP 1648 Caenorhabditi...
XP_018671834 1670 ISKTVRYFFQFLDREADRHKINDPEVLHIWKTNSLLLRYWVNVLKNPEFVF-DLNKTDIVDSCLNVITQAFMDACTTTNR 1748 vase tunicate
XP_016849234 1326 APVAIKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVF-DIKKTPHMDGCLSVIAQAFMDSFSLSEQ 1404 green anole
4M8N_A        496 HLDKHSPTNKLLYGKDIPQYKQEVKSYYKLVKDQTSISSQELKTFLQEESKKHQNE--FNESAALRELYKYMQR 567  zebrafish
6_pfamImport  479 QLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIHDMPPLSEQEMNAHLAEESRKYRNE--FNTNVAMAEIYKYAKR 550 
EGW12632      499 QLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNE--FNTNVAMAEIYKYAKR 570 
BAG58219      506 QLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENE--FNEEVALTEIYKYIVK 577 
XP_015207788 1400 QLGKHAPTNKLLYAKDIPQYKEEVKAYYKQIHDQPLLGFSEFTLFLEEESKKHENE--FNESAALHEIYKYIFQ 1471
EGD75945     1902 QLGKHSPANKHLYRKEVAEYKQKIANFYTAISRLPPPTDAELQASFASAQSGEQAC---DRPDAVCGLMEYALR 1972
EKC27333      647 KISKDSSLQKLLFAQEVPHYQKKTEQFYKALGNKAAITDADFWSEMSRLSLLQQEHlkFSKSAALVKLYRFVNQ 720 
O45657       1649 VLGAHSPSSRLLFAKDVARLRPLSVDLFKRVKNSPPLGMDELRTELVNMANDVSTC--KGSSLALSELLSWVRG 1720 Caenorhabditis elegans
XP_018671834 1749 KLGHDSPSNKLLYAKDADNYKVMVKEFFINISNTPTVTQEEVTQILQKQSASYASR--FNQMVALNGIYEHLVK 1820 vase tunicate
XP_016849234 1405 QLGKEAPTNKLLYAKDIPRYKEEVKAFYKAIKDLPPLSTSEIEDFLTQESKKHENE--FNEAAALMKIYQYIAK 1476 green anole
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