3H9R


Conserved Protein Domain Family
TGF_beta_GS

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pfam08515: TGF_beta_GS 
Transforming growth factor beta type I GS-motif
This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
Statistics
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PSSM-Id: 462503
Aligned: 16 rows
Threshold Bit Score: 28.3306
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3H9R_A        10 TLADLLDH-SCT--SGSGSGLPFLVQRTVAR 37 
EFX86076     191 TIKDMVDH-SQS--SGSGSGLPLLVQRTIAK 218
EDO30434     152 SLCDLITNaDIS--TGSGSGLPLLVQRTVAR 180
XP_008102182 173 TLEDLMED-DCT--TGSGSGLPFLVQRTVAR 200
Q659I3       133 YFPEFTD-------SGSGSGKPFLVSQTIAR 156 Echinococcus multilocularis
NP_001071834 208 TLADWME--SAT--SGSGSGLPFLVQRTMAR 234
OWR50038     240 TLRQYLEG-SAT--SGSGSGQPLMVQRTLAK 267
EDW47022     291 TIHDIIE--MTT--SRFGFGLPLLVQRSIAR 317
XP_002412676 179 TIKDMM-E-MTT--SGSGSGLPLLVQRSIAR 205
Q4H2Q1       171 GHNEMMENwSSLagTSSGSGMPLLVQRTISR 201 vase tunicate
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