1EG3


Conserved Protein Domain Family
EF-hand_2
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pfam09068: EF-hand_2 
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EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilization of the WW domain (pfam00397), enhancing dystroglycan binding.
Links
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Statistics
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PSSM-Id: 462668
Aligned: 51 rows
Threshold Bit Score: 99.1494
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EG3_A        44 TELYQSL-ADLNNVRFSAYRTAMKLRRLQKAL----------------------------------CLDLLSLSAACDAL 88  human
XP_002435276  52 VAIMDKL-TSFNDIKYAAYRTGAKLICLQKELlreqhcstkglssspgvhpvptddyhafrgalspAVSNVHVSMLPGVF 130
EDS33044      30 TYILNKInEKFATSKYSTYRCACKLFALQKAL----------------------------------FTNYIPFQTICTIL 75 
XP_002022772  35 SAIMEKLqVDYGKYKYTVYRCASKFVALQKIF----------------------------------HTSKIPYKLVLAIL 80 
XP_001963840  46 ASIIDELqMKYGNYKYTVYRCASKFVALQKIF----------------------------------HTGKVPYKLVLAIL 91 
Q24175        44 STIMDDLqRDYGNYKYTVYRCASKFVALQKIF----------------------------------HTGKIPYKLVLAIL 89  fruit fly
KYB26277      33 IELKHTI-DDWNYVKYSKYRVGLKFRALQKAL----------------------------------FMEEVTLSTVMGVF 77 
OWR55309      34 SKILKTL-DEYNDIKYSAYRIAFKIFALQRSL----------------------------------KVPPLRISS--GVF 76 
XP_012058338   2 ENIMRSM-QECNAIRYPSYRTAAKMQILHREL----------------------------------NMTHVQLELIAGVF 46 
EKC18153      39 LKVMEEL-DEYRDIRYAAYRTAFKIRHIQKRLkckype----------------------hahagqKVHHVKLEAMKEMF 95 

1EG3_A        89 DQHNLK-----QNDQPMDILQIINCLTTIYdr--leQEHNN--LV-NVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGI 158 human
XP_002435276 131 GCRGLEgs--gQQELLLGCSQAEAVLEELY------RRAPGvhQQ-KVPLLAALALNLLQNLFDAKRKGTIQVVQMKVAL 201
EDS33044      76 ERHRLNq---iDSAPSIKPSQLTAVLHDVYfaaeqlGYFAEltQQpDRDALISTLAGLLWSVFDPKRCNPLSVLELKQTF 152
XP_002022772  81 ERHGMPassgsNLNLMVPPFQLTSLLHDIYfaceklGHFTKtsSY-TLETATALLANFFWNIYDPQRRHSISLLEIRVTF 159
XP_001963840  92 ERHGLRg----NLELMVPPFQLTSLIHDIYfaceklGHFAQesSF-QLETASELLANFFWNVYDPQRRHSISLLEIKITL 166
Q24175        90 DRHNLSg----GLELMVPPFQLTSLLHDVYfaceklGHFNQdaNY-KLDRATGLLANFFWNVYDPQRRHSISLLEIRITF 164 fruit fly
KYB26277      78 AKHKLGm---nESSLCLESYDLEAVLYDIFf----aANKRNnkNI-DVDFAVELMQNFLYNIYDKERQVKIQVSSTKLAL 149
OWR55309      77 ARHQLSl---sETSLSLDTAELEAVLADIYf----aAEKEGlfTG-DVDLSVDLLINLLLNVYDGERKSPIRVLAAKTLL 148
XP_012058338  47 ERHRLSi---tENCVNLDPSEIEDVLSDIYf----aAQKESnfNF-DVDLVTKLATNYILNTFDKQNTGNILVFSVKVAL 118
EKC18153      96 DCHGYPe----SCDTVIGCEELQELLTSVYq----sADQAAniTIqQAEVFAQLLQNLVLNLFDVDRTGCLRVCSVKQVL 167

1EG3_A       159 ISLC 162 human
XP_002435276 202 FVLC 205
EDS33044     153 LLLC 156
XP_002022772 160 LLLC 163
XP_001963840 167 ILFC 170
Q24175       165 ILLC 168 fruit fly
KYB26277     150 ALLS 153
OWR55309     149 ILLS 152
XP_012058338 119 VLLC 122
EKC18153     168 IILT 171
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