1EG3


Conserved Protein Domain Family
EF-hand_2

?
pfam09068: EF-hand_2 
Click on image for an interactive view with Cn3D
EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Statistics
?
PSSM-Id: 430392
Aligned: 53 rows
Threshold Bit Score: 97.9841
Threshold Setting Gi: 242001266
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1EG3_A               44 TELYQSL--ADLNNVRFSAYRTAMKLRRLQKALclDLLSLSAACDALDQHNLK--QNDQPMDILQIINCLTTIYDRleQE 119 human
XP_023808713         24 RQIFVELgdQNFDSICLSTYRTACKLRFIQKRCnlHLIDIYNVIEAVRDAGLNavELNAGISVTRLENLVSSLFNQlsKR 103 Japanese...
CAG12938             92 RQLFVELgeQDFDAIRLSTYRTACKLRFIQKRCnlHLIDIYNVIEAIRDAGLNaiQPSAGLSTGRLENLVSSLFSQlaKR 171 spotted ...
ABF55373             16 RQLFAEMraLDLDSIRLSTYRTACKLRFIQKRCnlHLVDIWNIIEVFRENRLNsvELNTEFSVSHLQAILSTIFQQlnKR 95  zebrafish
EKC38734             39 KTLLTEMraQNFDVIRFATYRTACKLRFIQKKTnlSLVDIWNIIESFRENGLNtlEPDSELNSSRVEAIISSLFCNlnKR 118 Pacific ...
PCG75917             34 SQLLQEMreQNFDLIRFASYRTACKLRYVQKKCnlHVIDIWNVIEAFRENALNtlEPTACVNVTRLETLVSSLYHNlnKR 113 tobacco ...
XP_011057435         20 LQLLQEMrqQNFDTIRFASYRTACKLRFIQKKVhlHNVDIWNVIEAFRENGLNtlEPSSTLGVSRLETLLSSLFHAlnKR 99  Panamani...
WGS:AAQB:GK22187-PB   7 VAILQDLrlQTFDSIRFASYRTASKLRYIQKSTnlHLVDIWNVIEAFRENGLNtlEQQSEVSVARLETLVSSLYHNlnKR 86  Drosophi...
5_pfamImport          1 LQLMQEMrsQNFDLIRFASYRTACKLRFLQRKLnlHLVDIWNVIEAFREHSLNtmEIEAELNISRLESLISSLYQTlnKR 80 
XP_008187824         13 LQLLQEMrcQNYDMIRFASYRTACKLRYVQKKVylHMIDIWNVIEAFRENGLNtlESHVEVNVSKFETLITSLYLNlnKR 92  pea aphid
1EG3_A              120 HNN--LVNVPLCVDMCLNWLLNVYDTG-RTGRIRVLSFKTGIISLC 162 human
XP_023808713        104 LPTthTINPQESTVLLVQFILAAVDCE-PESRLTVLSVKAMLATLC 148 Japanese medaka
CAG12938            172 LPTthPIDARESTALLLQFLLAAVDSd-PGGCLLVLSVKAMLATLC 216 spotted green pufferfish
ABF55373             96 LPTthQINVDQSISYLLNFLLTAYDQe-GVGKISAFVMKMALATLC 140 zebrafish
EKC38734            119 LPStqQVHADQCVNMLQHWIISAYDRe-GYGRMSVFSLKVALSHMC 163 Pacific oyster
PCG75917            114 LPPahQVSVEACSALLLNWLLSAYSTGeNVGKIRVFSIKVALATMC 159 tobacco budworm
XP_011057435        100 VPVsqQSKVDATTALLMNWLLAAYTSGeN-NKISVFSVKVALATLC 144 Panamanian leafcutter ant
WGS:AAQB:GK22187-PB  87 LPTaqQVPVDSKAGLLLNWLLAAYTSD-NSGKIRVFSIKVALATMC 131 Drosophila willistoni
5_pfamImport         81 LPTaqQIHIEMSSTMLLNWLLNAYSEe-GMGRIKVFSIKVALATMC 125
XP_008187824         93 LPTqqHVHDDLLTTILLNWIMSVYSANdTMGRIRVLSIKVALVTMC 138 pea aphid
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap