2FA8,2OBK


Conserved Protein Domain Family
Rdx

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pfam10262: Rdx 
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Rdx family
This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.
Statistics
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PSSM-Id: 402052
View PSSM: pfam10262
Aligned: 242 rows
Threshold Bit Score: 45.5925
Threshold Setting Gi: 121982526
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2FA8_A          9 RIAIRYCTQCNWLLR-AGWXAQEILQTFASDI-GEVSLIP--ST-GGLFEITVDGT-----IIWERKRDG-----GFPGP 73  Agrobacterium ...
Q3UQA7         29 TVVIEHCTSURVYGRhAAALSQALQLEAPE---LPVQVNPskPR-RGSFEVTLLRSdnsrvELWTGIKKGpprklKFPEP 104 house mouse
NP_835234      39 RVVIEHCKSURVYGRnAVVVREALADSHPE---LKVMINPhnPR-RNSFEITLMDGer-adVLWSGIKKGpprklKFPEP 113 zebrafish
WP_011956119   11 KIRIVYCASCGYEPQ-TLELVSALMHAFHYDI-AGIEIIP--WQ-DGAFDVAVDGE-----LIHSMYRDG-----GFPAP 75  Roseiflexus sp...
P59797        264 lIRVTYCGLUSYSLR-YILLKKSLEQQFPNHLlFEEDRAA--QA-TGEFEVFVNGR-----LVHSKKRGD-----GFVNE 329 human
XP_003057240    3 KVHITYCGGUGYAPK-YKQVENAIKAKFPS---VESSGEPtpTS-SGAFEVVLDGTd----LVHSKLNGD-----GHVDS 68  Micromonas pus...
Q568W0          4 KVHVVYCGGUGYRPK-FIKLKTLLEDEFPNELeITGEGTP--ST-TGWLEVEVNGK-----LVHSKKNGD-----GFVDS 69  zebrafish
D0EYG3          4 RVTVLYCGAUGYKPK-YERLRAELEKRFPG-A-LEMRGQGt-QEvTGWFEVTVGSR-----LVHSKKNGD-----GFVDT 69  chicken
jgi:Tmar_2065   6 EVRIEYCTSUGYLPR-AARVAEEILAAYPDRV-ASLTLVP--SS-GGRFIVTAAGR-----EVYNKAETG-----RFPEE 70  Thermaerobacte...
jgi:Hoch_0529   5 pVSIEYCVQUNYTPR-AVRLTDELLTQFTHQI-ETLTMIP--SG-RGRFEVLVGDV-----LVFSKAELG-----RHAEP 69  Haliangium och...
2FA8_A         74 KELKQRIRD 82  Agrobacterium fabrum str. C58
Q3UQA7        105 QEVVEELKK 113 house mouse
NP_835234     114 AEVVTALKQ 122 zebrafish
WP_011956119   76 ETIIRAVRE 84  Roseiflexus sp. RS-1
P59797        330 SRLQKIVsv 338 human
XP_003057240   69 MEKLEKila 77  Micromonas pusilla CCMP1545
Q568W0         70 DSKMQKImt 78  zebrafish
D0EYG3         70 DAKLQRIva 78  chicken
jgi:Tmar_2065  71 GEVRKRMae 79  Thermaerobacter marianensis DSM 12885
jgi:Hoch_0529  70 GEVVKLVAa 78  Haliangium ochraceum DSM 14365
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