3N0A,3V0D


Conserved Protein Domain Family
PTEN_C2
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pfam10409: PTEN_C2 
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C2 domain of PTEN tumour-suppressor protein
This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.
Links
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Statistics
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PSSM-Id: 463081
Aligned: 48 rows
Threshold Bit Score: 82.3253
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3N0A_A        184 PHFKPLTIKSITVSPVPffnkQRN--GcRPYCDVLIGETKIytTCADFERMKEYRVQDGKIFIPLSITVQGDVVVSMYHL 261  cattle
A0BN98        246 VPQPKIQILQIRLITIPsm-nYSN--ScTPYILIQNYQNQA--TFTKFQIVNDS-----FILFTVDIIVEKDTRIICYNK 315  Paramecium te...
A0DZJ0        241 IPQNKIQISQIRLITIPim-nCQN--ScNPYILIQNNQSKI--LVSKFQIVKDS-----FIIFMTDAVVEGDTRIICYNK 310  Paramecium te...
Q54MG8        190 PPSITKVLSMIKMNSLPnf-nIGG--GcEPYLSIVQQGKSV--FYSKPVKLKKGTIHQQVELDCGNILLVNDVQIQFFNR 264  Dictyostelium...
Q9Y0B6        196 YSKVSLNVCEIRFSESScv-qNLGmvEcSISVLHDSATENA--KPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK 272  fruit fly
CAF94889      188 YKPVALLFHKMMFETIPm--fTGG--TcNPQFVVYQLKVKI---YTSSPSLIRREDKLMVFEFPQPLPVCGDIKVEFFHK 260 
XP_003964007  188 YKPVALLFHKMVFETLPm--fSGG--TcNPQFVVYQLKVKI---HTSNPSHTRREDKHMFFEFPQPLPVCGDIKVEFFHK 260 
Q6TGR7        190 YKPVALLFHKMVFQTLPm--fSGG--TcNPQFVVYQLKVKI---HTSNPAHTRREEKHMIFEFPQPLPVCGDIKVEFFHK 262  zebrafish
OCA27617      187 YRPVPLLFHKIEFETIPm--fSGS--TcNPQFVVYQLKVKI----FTSTAGPKRIEKLMYFDFPQPLPVCGDIKVEFFHK 258 
XP_014588672   55 YRPVALLFHKMMFETIPm--fSGG--TcNPQFVVCQLKVKI---YSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHK 127 

3N0A_A        262 RstigSRLQAKvtntqIFQLQFHTGFIPl--------------------------------------------------- 290  cattle
A0BN98        316 T----LMGKEV-----MFQFWFHTGFIEs--------------------------------------------------- 335  Paramecium te...
A0DZJ0        311 S----LLSKQI-----MFQFWFHTSFLDd--------------------------------------------------- 330  Paramecium te...
Q54MG8        265 N------SKGH-----MFSYCFHTAFIE---------------------------------------------------- 281  Dictyostelium...
Q9Y0B6        273 S------PDKI-----ICHFWLNTFFVRnyspce---------------------------------------------- 295  fruit fly
CAF94889      261 Qn--kMMKKEK-----MFHFWVNTFFIPapeenfsklengssstlr------------------------dlqqlgllvg 309 
XP_003964007  261 Qn--kMMKKDK-----MFHFWVNTFFIPgpeesrdklengavnnadsqq-----------------gvpapgqgqpqsae 316 
Q6TGR7        263 Qs--kMMKKDK-----MFHFWINTFFIPgpeeagdkvengsvvndvdslscqsqsspaerdrekeravaaaaldrergeq 335  zebrafish
OCA27617      259 Qn--kVMKKEK-----MFHFWINTFFIPgpeeysekvengtlvge-------------------------qeldgiyste 306 
XP_014588672  128 Qn--kMLKKDK-----MFHFWVNTFFIPgpeetsekvengslcdq--------------------------eidsicsie 174 

3N0A_A        291 ------dTTVLKFTKPELDaCDVP---EKYPQLFQVTLDVEL 323  cattle
A0BN98        336 -------NGLLVIDKYMLDrAVKDkkhKIFSPNFRVEVQTIT 370  Paramecium tetraurelia
A0DZJ0        331 -------TGLLIIDKYMLDkAVKDknhKVFSPNFRVEVQTFT 365  Paramecium tetraurelia
Q54MG8        282 -------GTKIHIRRQEIDkAHKDl--KHFHSNFSIELIFLE 314  Dictyostelium discoideum AX4
Q9Y0B6        296 -sdgtvnKYIHTLSKSEIDdVHKDsehKRFSEEFKISIVFEA 336  fruit fly
CAF94889      310 ldgserdQLVLTLTKNDLDkANKDkanRNFSPNFKVKLFFSK 351 
XP_003964007  317 cresdrdYLILTLSKNDLDkANKDkanRYFSPNFKVKLYFSK 358 
Q6TGR7        336 radgekdYLILTLTKNDLDkANKDkanRYFSPNFKVKLYFTK 377  zebrafish
OCA27617      307 rsdndkeYLTLTLTKNDLDkANKDkanRLFSPNFKVKLFFTK 348 
XP_014588672  175 radndkeYLVLTLTKNDLDkANKDkanRYFSPNFKVKLYFTK 216
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