3MP7


Conserved Protein Domain Family
Plug_translocon

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pfam10559: Plug_translocon 
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Plug domain of Sec61p
The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74.
Statistics
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PSSM-Id: 431358
Aligned: 115 rows
Threshold Bit Score: 29.6433
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MP7_A           38 ILYYVlAEIPVYGIPERIQDYFQFLRVVLAGR 69  Pyrococcus furiosus
Q12ZS8           38 VLYFAlANIPLFGLSSDSIDLFEQYRAFFAGA 69  Methanococcoides burtonii DSM 6242
O28377           39 LLYFIlSNVPVFGLSPESIDIFAAYRALFAGS 70  Archaeoglobus fulgidus DSM 4304
WP_013898497     38 LLYFAlRNVPLFGLSPESIDLFEAYRAFFAGA 69  Methanosalsum zhilinae
sklmb:Mhar_0453  41 ILYFAlSNVSLFGLSPASIDLFGMYRAFFAGS 72 
A0B9U7           41 LLYFVlSNIPLFGLSKHSIDLFGYYRAFFAGS 72  Methanothrix thermoacetophila PT
WP_015589740     40 ILYFIlSGIPVFGLSPDSIDIFEHYRAFFAGA 71  Archaeoglobus sulfaticallidus
ABN06281         39 LLYFIlTNIPVFGLSATSIDVFEYYRALLAGA 70 
Q2FSG8           39 ILYFAlTNIPVFGLSPESQDMFQYFRALLAGS 70  Methanospirillum hungatei JF-1
jgi:Mpal_0465    39 VLYFIlSNVPLFGLDTSSLDLFQAWRALLAGA 70 
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