6EIC


Conserved Protein Domain Family
Hydrolase_4

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pfam12146: Hydrolase_4 
Serine aminopeptidase, S33
This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.
Statistics
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PSSM-Id: 403389
Aligned: 86 rows
Threshold Bit Score: 176.631
Threshold Setting Gi: 123057613
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EIC_A        27 TAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVlvrDISEYTADFDTLVGIATREYPGCKRIV 106
Q7NMI7        34 NEPFGTLLVLPGKGEHGGRYGQLAAGLAACGWQTWGLDPRGQGLSDGARSrigSYDEFLTDIAAALEALGREFPGRPAVV 113 Gloeobacter vio...
WP_012287353  62 TPVTHVVVALHGMNDYSNAFHLAGPFWAGQGIATYALDIRGFGRS-PDRGvwaPIELSVEDVRTAVSLVREAHPEAKVSI 140 Caulobacter sp....
Q9A6L0        59 GEPDWVVVGLHGMNDYANAYHLAAAWWAGRGIATYALDVRGFGRS-PARGvwaQPELVIEDVRLLVEAVRERHPRAKVAL 137 Caulobacter vib...
Q0C0F7        84 DNPEYVVVGVHGMNDYAEAFHMAAPYWARNGVTTYAYDQRGFGRS-PNKGiwpQEELMREDLRTAVNVARARHPDAIITV 162 Hyphomonas nept...
Q0C0F8        30 KSPRHVIVGIHGMNNYAGEFRLAAPEWVAEGRAVYAYDQRGFGRS-AGRGvwpDEELMREDLRTAVSLARARHPKATLTV 108 Hyphomonas nept...
Q2VZF7        59 AAPKAVIVAAHGMNDYSNAFDGPGKGLAAQGIAVYAYDQRGFGQA-PHPGwwsSTETMAADLRTVSRLLAARHGPAPLYL 137 Magnetospirillu...
CDL00324      55 GEIRAVVLALHGMNDYSQFFAEPAAHLARHGILSYAYDQRGFGQG-PHPRfwsSTDTMVADARAATDLLASRHPGLPFYV 133 Magnetospirillu...
Q2RYC2        66 GPVRAEILALHGFNDYSGAFETAGPALAARGIAVHAYDQRGFGTA-PGRGlwpGGDILVRDAREAIATLHARHPERPLYV 144 Rhodospirillum ...
Q60A38        64 TRPKAVVVAVHGFNDYSLAFEPLGSYLKTQGIGCYAYDQRGFGLA-PGRGlwaGVDAYTEDLETFVGQVRTRHPGVPVYL 142 Methylococcus c...
6EIC_A       107 LGHSMGGGIVFAYG--VERPDNYD-LMVLSAPAvAAQDLVSPVVAvAAKLLGVVVPGLPV---Q-ELDFTAISRDPEVVQ 179
Q7NMI7       114 LGYSMGAVTGVLAA--LRWPERIQ-GLICVSPAfVIDNRLRGLAKvFAYLGSWLFPQRIV---AsGYNPAAVTNCPLEQQ 187 Gloeobacter vio...
WP_012287353 141 AGESMGGAVTIAAMtsDRPPA--AdSILLFAPAvWGWsaQPLPYKtTLWITAHTTRSWVVkppEwLVKNVQPTDNIDELR 218 Caulobacter sp....
Q9A6L0       138 AGISMGGGLAISAMatPDPPR--VdKLMLFAPAvWGWsnQPLPNKlSLWITAHAKGDWVVkppEwLVRNVMPSDNIDELR 215 Caulobacter vib...
Q0C0F7       163 VGISMGGSVALTAFgsDRPPK--AdRLIVSGPGlRGWgaINPLYRvSLWATAHANPDWLVv-pPvGLVKIEPSDNNAMLR 239 Hyphomonas nept...
Q0C0F8       109 VAISMGSAVAITAFasDRPPS--AdRLILSGPGlSGWgvLNPAYAgTLMLMNSMSPGLIVr--PpAFAKPKMSDNTEFLA 184 Hyphomonas nept...
Q2VZF7       138 LGESMGGAVVIEATvhAPPPE--VrGIILSAPAvWGRasMPWYQRaALWLSYKVAPGWTL---TgRGLKIMPSDNIEMLR 212 Magnetospirillu...
CDL00324     134 FGESMGGAVAMLAA--TEPPA-GMdGIILAAPAvWGRsaMPWWQRlSLWLAYNVAPGWSP---SgHGLNIRPSDNVEMLR 207 Magnetospirillu...
Q2RYC2       145 LGESMGGAIAITALtgPEAPRDLVaGLVLSAPAvWGRdtMPWSYRaALWLASRVVPGLRL---SgKGLKRYPSDNLPLLY 221 Rhodospirillum ...
Q60A38       143 LGESMGGAVAIVAMtsARPPR--AdGLILSAPAvWSRdtMPWYQSlLLAVSSHTIPWLRL---TgEGLGVMASDNIEMLR 217 Methylococcus c...
6EIC_A       180 AYNTDPLVhHGRVPAGIGRALLQVGETMPRRAPALt--APLLVLHGTDDRLIPIEGSRRLVECVGSA--DVQLKEYPGLY 255
Q7NMI7       188 QIAADPLI-DGTTRPRLVVELHKAGAQCLRLAPRLa--IPTLILATAFDRIVDARGAQAFYDRLPG---DRTLHWYDDQL 261 Gloeobacter vio...
WP_012287353 219 RMGRDPLM-IWGARSDTLYGLVGLMEKAWASLGKVq--VPVAYFYGANDHIIPKEPTMEAARRLKP---DDRSAYYADGW 292 Caulobacter sp....
Q9A6L0       216 RMGRDPLM-IWGARSDTLYGLVGLMERAWRSPGAIs--TPVAWFYGANDHVIPRAPTVEAVSRLKS---GALTAYYPKGY 289 Caulobacter vib...
Q0C0F7       240 RTWSDPHM-TYRTRIDQVYGLVALMENANTAVARLkpnVPTLISYGARDIVIPENGVRRAADILPS---FVRTVYYPGGY 315 Hyphomonas nept...
Q0C0F8       185 LQDADPLH-ARENRVDQIAGVVTLMEQAHEAAGRLpagLPVLASYGARDEVVLPEGPRRTFKVFPP---GVRTVYYPNGY 260 Hyphomonas nept...
Q2VZF7       213 ALSRDPLV-IKETRVDAIHGMVDLMDAAQRDAPRLd--LPLLLLYGAHDQIIPPEPTWDAVAALPHLgtRQRAALYANGW 289 Magnetospirillu...
CDL00324     208 KLGADPLV-IKRTRIDAVKGVVDLMDQAEAAPAAIr--VPTLFLYGAHDEIIPSAPTWQAAGAIP----SRRAAFYANGW 280 Magnetospirillu...
Q2RYC2       222 RIAEDPLW-IRATRTDAMRGVVDIMDQAYARAGALg--GPVLMLYGLNDQIIPAEPIREVARRLPGEppLQRLAVYPEGW 298 Rhodospirillum ...
Q60A38       218 GLGRDPNV-IKATRVDAIHGLADLMDTAQERVPALk--TRTLVLYGERDEIIPRTPLMALLDKLPA---GTRFAYYHRGY 291 Methylococcus c...
6EIC_A       256 HEVFNEPE 263
Q7NMI7       262 HDLLHERR 269 Gloeobacter violaceus
WP_012287353 293 HLLLVDKQ 300 Caulobacter sp. K31
Q9A6L0       290 HLLLVDLQ 297 Caulobacter vibrioides
Q0C0F7       316 HMLLRDLQ 323 Hyphomonas neptunium ATCC 15444
Q0C0F8       261 HILLSDNQ 268 Hyphomonas neptunium ATCC 15444
Q2VZF7       290 HMLLRDLQ 297 Magnetospirillum magneticum AMB-1
CDL00324     281 HMLVRDLQ 288 Magnetospirillum gryphiswaldense MSR-1 v2
Q2RYC2       299 HLLTRDLQ 306 Rhodospirillum rubrum ATCC 11170
Q60A38       292 HLLLRDLQ 299 Methylococcus capsulatus
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