Conserved Protein Domain Family
DUF4559

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pfam15112: DUF4559 
Domain of unknown function (DUF4559)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.
Statistics
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PSSM-Id: 464510
Aligned: 8 rows
Threshold Bit Score: 319.064
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002603560    6 RRNNEGYKNWLRVGLALLATRDGLTNVTLRAAKELHAALKAK--LGDIVEKCT--CNPKKKE------------ECKDCK 69  
XP_015208433    6 RLNDTEYINWLKLGVCLMEIRPLLSALIETRLEDFHLKLKEK--RNDKRCSSR--CSVAKDQkl--------thLCEICR 73  
XP_002124675   63 RFLTKQFQNWLQVVLALRFASEYVAPVINQAVKEMHHQLLFK--YGSK-------CIPYQQLkllr----tsgkVPPSLN 129 
EEN46655        6 RFNNPGYKNWLRVGIALLTTRDGLTNVTEQAAKELQAELKTK--LGDSVQNCT--CNPKSR-------------GCKDCD 68  
XP_002611951    6 RHNNPGYKNWLRVGIALLTTRDGLTNVTLQAAKELQAELKAK--LGDDVEKCT--CNSKSR-------------GCTDCE 68  
XP_005995314   56 RLNDVGYKNWIKAGFCLQQLTKGLRCYLNGEMETFHQTLRRS--LRARQPETA--CK--RNCrplgn---sfsnTCHVCE 126 
XP_694444       9 RFSDENYKNWLKTAESLYILRNRIQNFIEKETETYHSSLRNKqeLNGKTCHQN--CNDKDINqk---------sLCQLCE 77  
XP_015218820    8 RFTDTEYKNWLKTTMTLLLLRTRLETFLENETETFHSQLGNK--LMGQKCQARppCN----TkscgpqgtkppqVCPACT 81   spotted gar
XP_002603560   70 PWRQELATYYKGA---KSQIYWTNCTPNKW-----SKE--PWEVAKVFMPRGQSiANIG--PETSDTSALLNFLVHCKCC 137 
XP_015208433   74 EWSTVIKSYHKKP---KSYIYWNNCKPFRW-----CDD--ALEVAKAYMPSRQE-DNNQ--MSDFDIAALLVLMKQCTHF 140 
XP_002124675  130 NWIKDVKSNHRSSistGSLVRFTDVT--KW-----PTEdgSWEIARVFMSQGYR-SGTGntSSSFDTSALFSYMFRCRNF 201 
EEN46655       69 PWRDELKKYYTGD---ANRIGWTNCTPNKW-----RKE--PWEVAKVFMLKGQPaDNTG--PEKSDPSALLNFLVFCNYC 136 
XP_002611951   69 LWREELKTYYTGD---PNRIGWTNCTPTAFlpmlcLKQ----LLNKVFMLKGQPaDNTG--PEKSDPSALLNFL------ 133 
XP_005995314  127 GWKSEILMHHTHR---NNIINWGNCRPWLW-----PTQ--HWEVAKAYMPRGQT-DKLG--PDDCDAAALLNLINFCDHF 193 
XP_694444      78 CWRKEIVANHNG----KYGIHWNNCKPNRW-----STD--KWEVAKAYMPRGHR-DHCE--FSHFDVAAILNFMNFCKHF 143 
XP_015218820   82 QWKDEILSNHSNR---KGIIYWNNSRPHLW-----PTE--KWEVAKVYMPRGNK-DHSK--VQDFDISAFLNLMKVCTHF 148  spotted gar
XP_002603560  138 NKYv-sVKATQ-KVI-----EVRNRTMHSADLTFSQQAFQYHMSALLNLMRDP--TLGSDQAAKKAAD-EISK------- 200 
XP_015208433  141 EKLv--PESVLdKIQ-----DIRNTLMHSPDMKISSTDAEGFFKDIFMFFEAMksTDPLLEETVCEVEnKTHK------- 206 
XP_002124675  202 ERYlqdINVAK-NIL-----EVRNNAMHSPRLEFTDQQMKEYFGIISCLFDD-----------------ERLI------- 251 
EEN46655      137 RKYiskVEPLK-NVI-----EVRNKTMHSLDLRLDRQTFNEYMDKMERLLR-----LVGDPTAQKAAK-EIFK------- 197 
XP_002611951  134 -------------VI-----EVRNKAMHSLDLTFDSQTFNEYMDKMERLLR-----LVADTTAKEAAE-EILK------- 182 
XP_005995314  194 HFVn--PLKVR-EII-----RCRNELMHSSEMQVSPAWMKEYGQKLQDLLQDFm-HVPDVVHAGRTIE-EV--------- 254 
XP_694444     144 SKIq--GHHVR-NVI-----NVRNNVMHSPDLKMSNEDMKKHHSTILLLANMLqpQVPELNGLEEEIK-QYNN------- 207 
XP_015218820  149 KK-------YVnTIAldqvtNVRNKMMHSADMKVATQDMMTHMQKILHLVTELkkHVPSMFELETAIK-ELQEtelnill 220  spotted gar
XP_002603560  201 -IQTGEFHIGADKacadaevrvltdlmegyrKSLELHEKELGDHAT------------RLDAL----EQGMVSGEEVpsk 263 
XP_015208433  207 -ICRSPLNISLRE------------------DLKNREIAVFKENILalhtgadkdsfqKVNLIllrrQEWCIQNGNP--- 264 
XP_002124675  252 -LETQQFEQSTKAl----------------qEFKEMRDRLAKTDYTkttikfigeenaMLSRCvsanQSQLISLRNLy-- 312 
EEN46655      198 -IKKEEFHIGAGKacmdaevrvltdvmnehqKLLQLHREELEDHGT------------RLDTL----EHCTVPKEEMlk- 259 
XP_002611951  183 -MKKEEFHIGDNKacmdaevrvltdvmkehkKLLQLHREELEDHGT------------QLDTL----EHST---EEIrk- 241 
XP_005995314  255 --LDCDWTISTSEkdqidglds-gselisseQISEVEVALVKE---------------RLQEMclqlEEQNILSQEDit- 315 
XP_694444     208 -TLDQNFNKPLCEvdgqqi-------nvhtrELLDRENQALKD---------------KIKDIissfEGNQEENVNGklq 264 
XP_015218820  221 gNVEQKPDLPVFEsgslvd------tllsvqKIHDLEQQALKE---------------KIESLalrfEDEKILPESHee- 278  spotted gar
XP_002603560  264 aiNSILDMVNGNAD-LQsvlqgq--aselsTILQQYQTRLGKVEGDVSNIKDEVNQL 317 
XP_015208433  265 --QGLAELLNKVRDeLK-------------KDFTEIKQKVDCIDHKLQNIDERVAQL 306 
XP_002124675  313 -dNITRDFVNVSKQaLTlnk-------acdQFQQKIENQLDHLDSKVTSLHKQVDEF 361 
EEN46655      260 tvEVLLKVVKNNTD-LHralkdq--alelsATVQQLQDRLGKAERDITEVRGAMGQL 313 
XP_002611951  242 tvEVISDMVNNNSD-LQclkdqvlgllelsTTVQQHDDRLEKAEGDITDVKSAMSQL 297 
XP_005995314  316 slQAFREFLKKNED-LEgflq------adlQRLQDVEHKLQRQGDDLKDTSKKrekq 365 
XP_694444     265 dfKHIMDFLDQNKD-LLenlg------pevNKLKEIQTKVDELDEEVSTLKVRMDQL 314 
XP_015218820  279 -lCMMKEFLDQNKD-LLvqlg------pqvKQLNFIFEKVHLHDQQLTVLTEKVDNl 327  spotted gar
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