Conserved Protein Domain Family
SCRE
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pfam15162: SCRE 
Protein SPO16 homolog
This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.
Links
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Statistics
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PSSM-Id: 464538
Aligned: 11 rows
Threshold Bit Score: 264.257
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006001669   9 AKWTTTVIISSTLRSHEVATSLISQQHRVRFSDTVEEGSIIFSLSGVAFIIVDVQK--LFGNVEEaVLLAKLEKFMCIHR 86 
XP_001376990  10 SKWTTTVIMSSSLQSHEVAAILKNENHRVRYSNSVEPGSIIFSLSGVAFLLIDAQE--CFRTTEE-TLLARIEKFIRIHR 86 
Q3KQP7        12 VQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKE--CMTSAEE-IFVTKIEKFINIHQ 88  house mouse
XP_019692995  10 IKWTTTIIISSSLKSCEVATALD-RSHKIRYSDSVENGSIIFSLSGVAFLLMDAKD--CFTSAEE-IFLAKIEKFTNIHQ 85 
NP_001264582  10 SKWSTTVIMSTGLQNHEISTILQRQQHRVRYSESVEIGSVIFSLSGVAFLLADIQD--LLARGEE-QFLERIQKFINIHR 86 
XP_005050406  10 TRWITTVIMSTALQDHEISTVLQRQQHRVRYSESVETGSVIFPLSGIAFILSDTQD--LLKTGEE-EFSKRIHKFINIHR 86 
XP_008107450  10 MRWITTVIVSSSLQGHEISMSLQNQKHRIRYSDSVEDGCIIFSLSGVAFLLADAQG--LFVTDRE-VFFERIKKFMSIHR 86 
XP_003444305   9 PQWKTTIIVSTSLQSHEIIRMLNAQQHRIRFSDSVHPGAFIFPLSGTAFLMVDPQD--LPEPSEEsGVFERIKKFVQVHR 86 
XP_005807175   9 AQWRTTIIISSSLQNHDTCRTLSAQQHRIRFSDSVEAGAFIFPLSGTAFLLVDPQD--LPEPLEEsGLTERIGKFVQVHR 86 
XP_007233672   2 SSWKTTVIVSTSLQNHEALWMILSQQHRLRFSDSVEHGALVFPLSG-TAFMLITPEefPEKSESS-KFFNRIEKFvqvhr 79  Mexican tetra
XP_015210722   1 ----------mngKSHETALALSAQQHRVRYSDSVEEGTYIFPLSGIAFMIVDTQE--CADSPGVsRLFEKIGKFIQVHR 68  spotted gar

XP_006001669  87 NSFLLLLAALHETREWETM-IRIQQRFLGSNLRIIPVHNTNDIVKSILTIAKATCKPAVDNIWCRMVMATAQITDRSLVW 165
XP_001376990  87 NSFLALSSALHGPGEWRLM-SRIQQRFLGDNLRIVPVHNPGNAVKLMTTIAKSTCKPYSDNIHYRMILAKAQIIEQSPVW 165
Q3KQP7        89 NSFLVLFAPLHGPEEWSLM-FRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVW 167 house mouse
XP_019692995  86 NSFLVLSAAFHGPEEWKLM-FRIQQRFLGSNLRILPVHNTVDVINLMCTIAKMASKPYTDNICYRMVTTEAYIIEQSPVW 164
NP_001264582  87 NGFLVLSAALHGPQEWNVM-FRIQRRILGSNLRIIPVHNTAETVKLMLTIAKMNSKPRADDVSQKMAMTKTHIIENSPVW 165
XP_005050406  87 NSFLVLSAALYGPEEWSVM-FRIQRRFLGSNLRVIPVHNPAEIVKLMLTMAKITSKSQADDTRCKMEMTKAQIMEKSPVW 165
XP_008107450  87 NGFLLLSAALHGPKEWDVM-FKVQQRFLGSNLRIIPVHNTAEAIKLMLTIAKTTSKPHLDNIRYRMLMAKSQIVEQSPVW 165
XP_003444305  87 NCFLLLHSPFKGKKELETL-TVIQNRFFGSNLRILPVQNTDEIVKGMLTIAKATSKPHVDSIRDRISLARAHIIESSPVW 165
XP_005807175  87 NCFLLLYSPFNGEKELQVL-TVIQHRFIGSNLKILPVRNGAQIAKGMLTIAKATSKPHADKIRERMSLARAHIIETSPVW 165
XP_007233672  80 nsfxllqSPVYGAREWEIVsT-VQKRFFGSNLKVLPLHSNVDIVKALLTIAKATSKPLVDSIRERMALARAQIIERSPVW 158 Mexican tetra
XP_015210722  69 NSFLLFSSSLHAQREQEIL-FRIQQSFLGSKLRIIPVHNVAEMVKSMLTIAKATSKPHVDSVRDRMALARAQIIERSPVW 147 spotted gar

XP_006001669 166 EMLHKL 171
XP_001376990 166 RTLQKL 171
Q3KQP7       168 RTLQKI 173 house mouse
XP_019692995 165 KTLQKL 170
NP_001264582 166 KMLQEY 171
XP_005050406 166 KMLQEY 171
XP_008107450 166 KMLHQR 171
XP_003444305 166 EMLRDM 171
XP_005807175 166 EMLRDI 171
XP_007233672 159 EVLGHM 164 Mexican tetra
XP_015210722 148 DVLSRL 153 spotted gar
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