Conserved Protein Domain Family
EPOP
?
pfam15223: EPOP 
Elongin BC and Polycomb repressive complex 2-associated protein
This family of proteins is found in eukaryotes. Family members are approximately 835 amino acids in length and include the polycomb repressive complex 2-associated factor EPOP (Elongin BC and Polycomb Repressive Complex 2 (PRC2) Associated Protein, also termed C17orf96, esPRC2p48, E130012A19Rik), a scaffold protein expressed in the inner cell mass of the mouse blastocyst serving as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex, and fine-tuning the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells. Both EPOP and Elongin BC are required to maintain low levels of expression at PRC2 genomic targets. EPOP interacts with the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC. Functional studies found that the C-terminal region of EPOP directly interacts with PRC2 and that this region associates with the VEFS-box of the PRC2 core member SUZ12. Thus, suggesting that EPOP may directly affect PRC2 chromatin binding by altering the functionality of Suz12. This region is proposed to have evolved in early vertebrates and is also present in the paralog SKIDA1 (C10orf140) another novel PRC2-interacting protein, supporting the idea that proteins possessing this sequence are PRC2 regulators in the entire vertebrate branch. The family is found in association with pfam02437.
Links
?
Statistics
?
PSSM-Id: 434546
Aligned: 5 rows
Threshold Bit Score: 435.92
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q80YR3       385 SVQAQANFLYHLAS--AAAATKPAafEDAGRLPDLKSS--VKAESPEEWSLQSWAPKGTPVYCPASLGSC-FPEIRNDRV 459 house mouse
XP_005997144 387 TLLAQASFQYQIPTktHNSDAGRL--DEISEGKPTHYD--LKFAFQEKKNGQSCLSKPQNVRYSASFGSC-FSEIKRDRI 461
XP_002596974 407 NLSQEQGLQQRSVAngCLQGVGFAleGAKNGLQVPLTQfvTSSLSHAPPLDTDCLPSPPTSPQSASL----VLKKQGKKT 482
CAF97972     435 PLLLQPTFHYNNQPq-HDTQHHTP----SAGGDDSRHEkrQKCEFICTESGKDFGASQISKLSSAATGKSfFTEQKLQK- 508 spotted green p...
XP_015210037 385 PLLAQPSFHYNLHQrpTNQSGATLldYGIASRKLPKSD--VKLGVVKKQQDESHATKQRSLF-PAIPASC-FPESKRERE 460 spotted gar

Q80YR3       460 SEITFPHSEIsSTVKRTDLTINchaEGASSPSPKTNNVF-PQQRI-LREARKCLQATPTtHCAENSTIAARFLNNdscgT 537 house mouse
XP_005997144 462 SETAFPHTEF-SNVKNTDPTIK---ETISSPSPKKSTEL-SQERI-FREAKKCVQSTGL-HGAEYDVLCGSLTND----S 530
XP_002596974 483 WAV--------DSIKVSPPQENvlvEREDVRGSKEERKTsCTMKSpLRSSPKHGRGRGAsRKQNNEVIKKPGAKK----A 550
CAF97972     509 -----------ADLNRTDSSGE---LTSYLPGCN-WKAFqSPRRT-TGHPTKGSSGPGApSHLDT----LPKCAE----- 563 spotted green p...
XP_015210037 461 REIALSHFEIsDDSKRTDPTINsfkERGSSPCPKENKEF-PQQRI-LGQANKYPSAP-IsHCAEHKETIVPQLRDnnssL 537 spotted gar

Q80YR3       538 TANSGKDSKIPHCPEFATDLPSLQSDPRvdtaTAAAAAAAatkaeslctgTGDKTLPF-LHNIKIKVEDSSANEE----- 611 house mouse
XP_005997144 531 SENSEKESKVSSYSKLPPIFHCIKSDGE----LSAENQYE----------EAYQDLTF-PHNIKIKVEENSCNEE----- 590
XP_002596974 551 ILNGTKVSLSPKQGKVANNFKKVPSNSQdv-sQKKKRKLNnde----avfSGVKKMRMeHPGEKARSPQKGPNGYiqnat 625
CAF97972     564 ----KREARTANQ-KPSSPVKKIKSEAEet-cVTAGPHAVn--------gRTARTPPFnLHNVKIKVEESLDEYE----- 624 spotted green p...
XP_015210037 538 ALNFKKEVKINNCSKLPPPFNTVKTETEey-tLSTNSHIQs--------tNTGKAPTF-LHDVKIKVEDNFDE------- 600 spotted gar

Q80YR3       612 YEPEL--ITNKLKWECNDAEGEFYNMTEKKEEDALVpTAKEGFACPEKET---------PSLNPLAQSQGLSC-----TL 675 house mouse
XP_005997144 591 YDSEAqdIKDKLKYECNVFKEELTNLNENNTREALA-QAKEDFTSTEKQT---------TSQNVLTQSQEPPC-----TL 655
XP_002596974 626 FSPKLskIPPTLDDTAKLTENELAIKLEAISSEIDN-LRRSKTNKKKLKN---------KVL-PRTKAQIPQRk---sNL 691
CAF97972     625 YQSQD------SSVKCKTDTSNG-------QHQSGA-IKQADFFSGEIKT---------TERGP-GVSPESPCgpqecVQ 680 spotted green p...
XP_015210037 601 YSSVGefSETGSEYKHSVDDDDVTTNT---KCLNGA-DRRTDTLDNANKTtaiaenpaaSQKSP-TRNQEFQS-----TL 670 spotted gar

Q80YR3       676 GSPKPEDGEYKFG---ARVRKNYRTLVLGKRPVLQTPPVKPNLKSARSPRPT--GKTETHEGTLDDFTVLNRRKKVASNV 750 house mouse
XP_005997144 656 STPKPEDGEYKYG---ARVRKNYRTLVLGKQAAQHATPVKANLKSDRSPRPA--GKTYLHEGTLEDFTVSNKRKRVASNV 730
XP_002596974 692 KTSKPDLKGTRKK---RKVSPTQKTNLSSKSSEKKDKTLSKGI-----------AKTQPTEEGLE-----SRTKKGSYHS 752
CAF97972     681 EKPCTDEEKAVSKsckPAGPRSKRSGVFGARTKRKVPRINQAASSCSSPSSSrpGCEDASAEDLP-----SRRKRNAGNP 755 spotted green p...
XP_015210037 671 RSPFPELGEYKNG---ARVRKNYRTLVLGKHSEIQRTPLKLNVK-DRTPRST--GKNEFYEGSLEDLSSTGKRKRASSN- 743 spotted gar

Q80YR3       751 ASAVKRPFNFMANFPCPPSLIIGKDGDLWPAYSLNTTKDSQPPHKAHPIWKWQLGGSAIPLP---PSHKFRKF 820 house mouse
XP_005997144 731 ASAVKRPFNFMANFPSPPSLIIGNDGDLFPAYSLNTAKDPQPPHKAHPIWKWQQGGSAIPLP---PSHKFRKF 800
XP_002596974 753 MAPGRKTFSLLAQFPWMPTLTIGVDGDLAPAYTMRLEPGTKPSRK-HPAVKWKIGGMPYSKPgtvHASELRKR 824
CAF97972     756 TSPGKPSFSLMANFPTPPSLVVGSDGDLCPAYSLNSLRGPGPPPPSHPVWRWQPGGHVLPPP---QAPKTRKY 825 spotted green pufferfish
XP_015210037 744 -MTVKKPFNFMANFPSPPSLIIGNDGDLSPAYSLNSVKDNQPPHKSHPVWKWQLGGSAVPLP---PSHKFRKF 812 spotted gar
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap