Conserved Protein Domain Family
PTRF_SDPR

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pfam15237: PTRF_SDPR 
PTRF/SDPR family
This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.
Statistics
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PSSM-Id: 464578
Aligned: 22 rows
Threshold Bit Score: 265.82
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003978032  68 QANGVIVLSLLDKIIGAVDQIQQTQSGLESRQQEMERCVTGIQGELTKLTKSHSTTSNSVNKMMEKVRKVSINVKTVRAT 147
XP_001363685  46 QVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGS 125
XP_004747756  27 QDAALTIVTVLDKVATIVDSVQASQKRLEERHREMENAIKSVQIDLLKLSQSHSNTGYVINKLFEKTRKVSAHIKDVKAR 106
XP_006010362  26 QVNIMTIMSLLDKVAEIVDSVQASQRRIEERHTEIENSIKTIQIDILKLAKDHNTTGSTVNKLLEKTRKVSSNVKDVRAR 105
XP_006634597  27 PISTLTILSLLERVAGIIDNVQACQQRMEERQLELENNIKTIQIDVLKLAKDHSITGNTVEKLLEKTRKVSSNVKDVRQR 106
NP_001008579  13 EPSAMNIFSLLERVSGIIDNVQACQQRMEERQLELENTVKTIQADVVKLTKEHTATSGTVEKLLEKTRKVSCHIKDVRVR 92 
A1L260        18 PVSALSILSLLERVSTIIDGVQASQQRMEERQQQLEGSVSAVQSELLKLARDHGATATTVDKLLQKARRVSTHVKEVRSR 97  zebrafish
XP_005812677  27 PISALTILSLLERVAGIIDNVQSCQQRMEERQLELENNIKTIQGDVLKLAKDHSDTSGTVEKLLQKTRKVSANVKEVRTR 106
XP_012398157  27 QDAALTIVTVLDKVATIIDSVQESQKRIEERHRTMENTIKSVQIDMLKLSQAHNNTGYMVNKLFEKTRKVSAHVKEIKAR 106 Tasmanian devil
XP_005041886  28 QDAAYTIVTVLDKVANIVDSVQASQKRIEEKHREMENAIKTIQIDILKLAQAHGNTGFTVNKLLQKTRKVSSTMKEVRAR 107 Collared flycat...
XP_003978032 148 LEKQGGQIKKLENNEAELLKRRNFKVMIYQDDVKVSSKLSMSKSmkfSEYasgsrggsllelketveePGEDEVADeEKT 227
XP_001363685 126 LERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSlkeSELlpek-------------egdELGEGIeKPE 192
XP_004747756 107 VERQQVHVKKVESKQEEIMKKNKFRVVIFQEEIRCPTSLSIVKDr----------------------sLTENQETEeDVF 164
XP_006010362 106 VDKQSARVKKVETTQEELLRKNRFRVVIYQGETEVPCAS-VSKFpkd-------------------cavSGGQEENlDNE 165
XP_006634597 107 VEKQNIRVKKVEATQEELLMRNKFRVVIYQGETEIPSVA-VTKTpkg-------------------apgVS--TVEpDTY 164
NP_001008579  93 VEKQNVRVKKVEETQVELLNKNKFRVVIYQGDNEVPAVAGPKASpkga-----------------mggDAA---ADpDAP 152
A1L260        98 VEKQNVRVKKVETTQDELLTRNKFRVVIYQGEKEVPSVA-VTKTpkg--------------------agLAELEVEpDEY 156 zebrafish
XP_005812677 107 VEKQNIRVKKVETTQDELLTRNKFRVVIYQGETEVPSVA-VTKSpkg--------------------lgLEGLDIEpDAY 165
XP_012398157 107 VEKHSLNVKKVETKQEEILRKNKFRVVIFQEEVPCPTSLSVVKE------------------------KSLLEDTQeDEF 162 Tasmanian devil
XP_005041886 108 VERQSTSVRKVEAKQQEMLRKNKFRVVIYQEETECPSSLSVIKE-------------------------MTAGETIeDDF 162 Collared flycat...
XP_003978032 228 EqpHVDLSSDEEGlEIEQTIEASRAERIKRSSLQRVQNLKTVFSkdkmdktraktkeniertkqktieniektkqktrdn 307
XP_001363685 193 DdaTLELSSDEAV-EVEEIIEESRAERIKRSGLRRVDDFKKAFSkekmektkvrtrenl--------------------- 250
XP_004747756 165 Dp-pIDLSSDEEY-YVEE----SRSARLRKSGKERIDNIKKAFSkenm-------------------------------- 206
XP_006010362 166 TgpPADLSSDEEY-MVVEEQETA-AARLKKSGLKRIDTIKKAFTkeni-------------------------------- 211
XP_006634597 165 Da-pADLSSDEEY-MVVEEADSSTAARLKKSGMRRIESIKKAFTkenm-------------------------------- 210
NP_001008579 153 EapLPD--SDEEY-MVVEEADSSTAAKLKKTGLKRIESLKQTFSrenm-------------------------------- 197
A1L260       157 Di-pADLSSDEEY-MVVEDAESSRGARLKQSGLKGIENIKAAFSkenm-------------------------------- 202 zebrafish
XP_005812677 166 Di-pADLSSDEEY-LRDEEPDPSRAARLKKSMVKSTETLKAAFSkenm-------------------------------- 211
XP_012398157 163 Cl-pDDLSSDEEy-EIEE----SRAAQFKKSGKKQIDNIKKAFSkenm-------------------------------- 204 Tasmanian devil
XP_005041886 163 Fp-pDDLSSDEEY-YIEE----SKATKFKKSGMRRIDDIKKAFSreni-------------------------------- 204 Collared flycat...
XP_003978032 308 lertkqktkdniertkqktkaniektR------------------HNIEKKMEkigtRMsVNPEHKqkiq---------- 359
XP_001363685 251 ------------ektrlktkenlektR------------------HNLEKRMNklgtRI-VTAERRekmk---------- 289
XP_004747756 207 -----------------------qktR------------------QNFDKKVNrirtRI-VTPERRerlrqsg------- 237
XP_006010362 212 -----------------------qktR------------------QNIGQKMNristRI-VPPERRekirqs-------- 241
XP_006634597 211 -----------------------tktK------------------QNLGTKVNqistRI-VTPERRekir---------- 238
NP_001008579 198 -----------------------tktK------------------ENLGTKVNklgeRI-VTAERRekir---------- 225
A1L260       203 -----------------------nktRektrenlsktkeslsktgQTLGTKFNtlgeKI-VPPEQRe------------- 245 zebrafish
XP_005812677 212 -----------------------sktK------------------DNLGTKIHnlgeKV-MPPERRekmq---------- 239
XP_012398157 205 -----------------------qktR------------------QNFDKKVDrirtRI-VTPERRerirqsgerlrqsg 242 Tasmanian devil
XP_005041886 205 -----------------------qktR------------------QNFGKKVNrlqtRI-VTPERRerir---------- 232 Collared flycat...
XP_003978032 360 ----tsrDKMKKAFTPDHVVY-ARSKTAVYKVPP 388
XP_001363685 290 ----tsrDKLRKSFTPDHVVY-ARSKTAVYKVPP 318
XP_004747756 238 erlrqsgERLKQSG--------ERFKKSISNAAP 263
XP_006010362 242 --gektgERLRQSG--------ERLKQSITKAAP 265
XP_006634597 239 ----qsgERIKHSG--------ERLKESISKAAP 260
NP_001008579 226 ----qsgERLKQSG--------ERFKETITKTVP 247
A1L260       246 --------kIKQSS--------ERLKENIAKKAP 263 zebrafish
XP_005812677 240 ----qagERLKQSG--------ERLKENIAKKAP 261
XP_012398157 243 erlrqsgEKLRQSSGERLKQSgERFKKTISKATP 276 Tasmanian devil
XP_005041886 233 ----qsgERLRQSG--------MRIKKSISQAAP 254 Collared flycatcher
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