Conserved Protein Domain Family
FAM53

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pfam15242: FAM53 
Family of FAM53
The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.
Statistics
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PSSM-Id: 464582
Aligned: 17 rows
Threshold Bit Score: 218.155
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003773489  14 MVTLITEKLQ-NQSLDDLTCKTYNINLYSSEELNKSGSLFPFEINvEENPWKVLNGGCPIRTEV--------------TK 78 
Q66IH4         1 MVTLITEKLQ-NQSLDDLSCKTYNLNLHPSVKLNKSACLFPYEIN-EDSPWKVLNGTYPIRNEVnknsifsfstcpysAG 78  tropical clawed...
2_pfamImport   1 MVMILTKTRE-NKGADSVTCRT---ELHTP-KMSQGPTLFSCGIM-ENDRWGDLSRKCPLQIEQ--------------PG 60 
XP_007079780   1 MVMILSKSLD-NQGADSIACRTFNPELHTPKKMSQGPTLFSCGIM-ENDRWRDLDRKCPLQIEQ--------------PS 64 
XP_016847708   1 MVMILTTALE-NKGADSLSCRA---ELHTPKKMSQGPTLFSCGIM-ENDRWRDLSRKCPLQIEQ--------------PS 61 
XP_006630583   5 MVIIHPKTLEkKKGVDDVTCKASDSELQKPQKMSKGTALYACGVV-ESDGWRDLGRGCAFQKDP--------------GG 69 
XP_003441827   5 MVIIYPKTLE-KKGADDVTTKRTNFVPFQAQTMSQGTALFSCGLM-DTSRWRDMGHRCAIQRRP--------------VG 68 
XP_003961199   5 MVIIYKKTLE--KGAGDVKSNSTGLGPFQAQIMSQGAALFSLGLA-EASQWSDKSHGCAIQQRP--------------VG 67 
XP_013211377   1 MVTLITEKLQ-NQSLDDLTHKACEAGPYSAEQLNKSGHLFPLEVSvDESPWKAFHTGRPAGSQAaagpvc--pflpgpCG 77 
XP_031410454   1 MVMILTKTRE-NKGADSVTCRT---ELHTP-KMSQGPTLFSCGIM-ENDRWGDLSRKCPLQIEQ--------------PG 60  turkey
XP_003773489  79 VSafpfpscpfssANMCLQWQKESPS-PSMVSGWISELNLNENSGQPL-APPPKRHCRSLSEPDELARCRSPWKPGNSKV 156
Q66IH4        79 TS-----------GSYSLQWQNESSS-ASKVSGWISELTLNDSFGQPL-APPTKRHCRSLSEPDELSRCRSPWKPGNSKV 145 tropical clawed...
2_pfamImport  61 TSiwdc---ladkGEEGTLWPREATS-TCSVTNLIKELSLSDPHSNPS-APPSKRQCRSLSFSDEMSSCRTSWRPLGSKV 135
XP_007079780  65 ASiwec---lpekCQDGALWHREAAT-ACAVTNLIKDLSLSDHNGNPS-APPSKRQCRSLSFSDEMSSCRTSWRPLGSKV 139
XP_016847708  62 TNiwdc---lpdkSKESSIWQREAAS-TCSVTNLIKDLSLSDHSGNPS-APPSKRQCRSLSFSDEMSSCRASWRPIGSKV 136
XP_006630583  70 ASleclwgvlpgpYQGSRGWVKEAGA-ASAITNLIRDLSLSDAKGSPSaAPPSKRQCRSLSFSDELSVCRPAWRPQGSRV 148
XP_003441827  69 TSleslwdvlpevHTSSAHWDWDVGStSSTITNLLQDLSLTEA-SHST-APPSKRQCRSLSCSDELSGCRSSWRPQGSRV 146
XP_003961199  68 TSleslwdvlpeaHEGSSHWDWDVSStSSTITSLLQDLSLKEG-LQST-APPSKRQCRSLSCSDELGS-RSTWRPQGSRL 144
XP_013211377  78 VA-----------HTEGLQWRSESPC-SCTGPGVDSALNLCENTGPPV-APPTKRHCRSLSEPEELARCRSPWRPGSSKV 144
XP_031410454  61 TSiwdc---ladkGEEGTLWPREATS-TCSVTNLIKELSLSDPHSNPS-APPSKRQCRSLSFSDEMSSCRTSWRPLGSKV 135 turkey
XP_003773489 157 WTPVSKRRCNSGGSATLQRCNSG-----GSATLQRSTSISLPQSVLSLQnvfpvtgFHTSPV-PRPSSASSGFVDS---- 226
Q66IH4       146 WTPVSKRRCNSGGSTTLQRCNSH-----GGGNLQRSTSISLPQNPLTVKhifaasnCDTSPV-QRPSSASSGFVDS---- 215 tropical clawed...
2_pfamImport 136 WTPVEKRRCYSGG--SVQRYSN------GSATMQRSSSFSFSPSEQPLVas----pVLQGRIsYRPGWEFCAALNI---- 199
XP_007079780 140 WTPVEKRRCYSGG--SVQRYSN------GFSTMQRSSSFSLPSRANALSs-----pYDQAGFhHRFGGQPCQGAPG---- 202
XP_016847708 137 WTPVEKRRCYSGG--SVQRYSN------GFTTMQRSSSFSLPSRSNPLSs-----fCDQSGFsNRFGCQPCQGMRR---- 199
XP_006630583 149 WTAVEKRRCHSGG--SVQRGPCTl---pGYPAMQRSSSFSLPARSNAFPqht--acLPIAGFqPSPPSSSSSSTSE---- 217
XP_003441827 147 WTAVEKRRCHSGG--SVQR-SSIgnmqsGFAGMQRSSSFSLPARSNTLE-------LPSFTQrPPWSSGFTSLTPSssss 216
XP_003961199 145 WTTVEKRRCHSGG--SVQRGIGNaq--lGFPAMQRSSSFSLPARCNTLE-------LSCFSQcAPCPSAFTSLTLS---- 209
XP_013211377 145 WTPVSKRRCNSGGSATLQRCSP------GSSSLQRSPGAGLPRSPTSPA-------GPISPLvPRPASASSGFVDS---- 207
XP_031410454 136 WTPVEKRRCYSGG--SVQRYSN------GSATMQRSSSF----------------------------------------- 166 turkey
XP_003773489 227 ---SEG-STSSSIRWNSA----GPCDFNPRRRLSLSQEHIPEAGNLLPSANSTPTSTPELSRR---QGLLRCRSQPCVLN 295
Q66IH4       216 ---NEG-SAASNVRWNSA----GPSEFNPRRRFSLSQEHITENADLSPSANSTPTSTPELRRR---QGLLRCRSQPCVLN 284 tropical clawed...
2_pfamImport 200 ---SASgSGSASVRWSAQkmpiGGGLLCSQVPLPCPSEKLHSSHLLAGAADNAQGGGPVPARTs--LGPSWAENEPCFLI 274
XP_007079780 203 ---SAT-CGQAGDIWSPDptpvGGGRLDMQRSFSCSHEQFSFAEYCPPSANSTPASTPELARRs--SGLSRSRSQPCVLN 276
XP_016847708 200 ---SAT-YGQASDIWGSDhssiESSRIDIQRSLSCSHDQISFSEYCLPSANSTPASTPELTRRs--NGLSRSRSQPCVLN 273
XP_006630583 218 ---ATGdSAAGP------------------RPLSLSHEQICLPEPRGPSADSSPDSTPELGRRagpGGLSRSRSQPCVLN 276
XP_003441827 217 vplSSDpSSQP---------------------LYLSHEQICLPEPRGPSPPSSPDSTPELERRggqGGLPRSRSQPCVLN 275
XP_003961199 210 ---SSEpSAPPL--------------------LHLSHEQICLPEQPEPSPPSSPDSTPELERRggqGGLARSRSQPCVHN 266
XP_013211377 208 ---SEGsSSGSGLPWRPT----GPCPLSSRRRLSLSQEHLAEAGTHLPSASSTPTSTPELGRR---LGLLRCRSQPCVLS 277
XP_031410454     --------------------------------------------------------------------------------     turkey
XP_003773489 296 EKK--SRLKRRREEDVRWNRPSLD--FFKMTR 323
Q66IH4       285 ERK--TRLKRRRDEDVRWTRPSLD--FFKMTR 312 tropical clawed frog
2_pfamImport 275 LKRsvSVRARRSPEEIHQATPSLDssLPFLPQ 306
XP_007079780 277 DKK--VGVKRRRPEEVQEQRPSLD--LAKMAQ 304
XP_016847708 274 DKK--VGIKRRRPEEVKEQRPSLD--LAKMTQ 301
XP_006630583 277 EKK--IGVKRRRPEEAPEQRPSLD--LAKMTQ 304
XP_003441827 276 EKK--TGMKRRRPDDTHKQRPSLD--LAKMTQ 303
XP_003961199 267 DKK--VGMKRRRPADSQKQRPSLD--LAKMTQ 294
XP_013211377 278 GRR--SRRKRRREEDARWTRPSLD--LLKMTR 305
XP_031410454     --------------------------------     turkey
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