Conserved Protein Domain Family
TSSC4

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pfam15264: TSSC4 
Tumour suppressing sub-chromosomal transferable candidate 4
This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.
Statistics
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PSSM-Id: 434584
Aligned: 13 rows
Threshold Bit Score: 126.474
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAQB:GK17414-PA   9 DALFACLDDASKELKGTG-------LDQSKAKpytiramerrhnarddrgqvmnyrcgqriqvdgetesedgklrrmrgk 81 
NP_064681            91 HSIFDCLESAARQAPCSA-------PQTSVSD------------------------------------------------ 115
XP_006141141         99 HDIFDCLEGTARQAPPCV-------AQTSMND------------------------------------------------ 123
PNI26611             30 RDIFDCLEGAARRAPSSV-------AHTSMSD------------------------------------------------ 54 
ELK13213            186 SSIFDCLEGAARRAPRSG-------AHTDVGD------------------------------------------------ 210
Q1LZD3               90 HSIFDGLEGAARRAVPAV-------TPASPGD------------------------------------------------ 114 cattle
XP_005996133         96 QSIFEGLENPTRLSLPT--------LNNNSDEeed-------------------------------------------vi 124
XP_011456531         25 KDIFGNLEKLEKKHEENTkfrtdddVDIQKSDhldvd---------------------------------------teti 65 
EEB18555             26 RNLFDILDSAEKEKKS---------CDNSCNDsmdidvnksssr------------------------rqrkitkqfrgq 72 
XP_001122509         21 KLLFDKLSDAEQECNKNKivnepmdMDSNIEQsnyfqilkagr---------------------------qsqtrrfrgk 73 
EDV96084              9 DALFACLDDASKELKGTA-------LDQTRSKpytinaleraknqgrkicaa--------gkadlvetetdeklrrlrgk 73 
WGS:AANI:GJ12103-PA   9 DALFACLDDASKELKGTP-------LDQSRAKpytvsaleranntknrnqvmnyr---qgrsievgndvedeklrrlrgk 78 
XP_002007559          9 DALFACLDDASKELKGTA-------LDQSKSKpytvvalekaknrnpvmnyrq------grsieagnevedgklrrmrgk 75 
WGS:AAQB:GK17414-PA  82 ESIFKKPEL----------------------PIG---------------------------RCLKPRK------------ 100
NP_064681           116 NGSFRRPVT----------------------PPS---------------------------QTPARGLsrvhgntgptrv 146
XP_006141141        124 SGVFKRPLV----------------------PSS---------------------------QPPVEGLgtthrgsvpsra 154
PNI26611             55 NGGFKRPLA----------------------PSG---------------------------RSPVEGLgrahrspasprv 85 
ELK13213            211 SGTFKQPPA----------------------PSG---------------------------QLPREGPgrasqspapprv 241
Q1LZD3              115 GGGFQQLLT----------------------PSS---------------------------QPAAGVPgraagspaaqra 145 cattle
XP_005996133        125 DGPFKRPLPq---------------------PAP---------------------------RRAAGDAaagkrrivgkkv 156
XP_011456531         66 TSAFKTPQLgrgsnregggpwrhraqhrdrgPPPwrehcdrgedrsadrgsssiqrelqpkQFGGRRGghpyynsrgnrr 145
EEB18555             73 ESLFNKPLS----------------------LPP---------------------------RFKKRNK------------ 91 
XP_001122509         74 ESIFKRPEG----------------------PAP---------------------------RALNRS------------- 91 
EDV96084             74 ESIFKKPEL----------------------PIG---------------------------RCLKPRK------------ 92 
WGS:AANI:GJ12103-PA  79 ESIFKKPEL----------------------PIG---------------------------RCLKPRK------------ 97 
XP_002007559         76 ESIFKKPEL----------------------PIG---------------------------RCLKPRK------------ 94 
WGS:AAQB:GK17414-PA 101 --TPDYQVNPHKWKKYSLSDV---DISEQTNSAAALSFL----------REMDAQRETDTIGQDDDELASS 156
NP_064681           147 lpVPDYVSHPERWTKYSLEDVs--EASEQSNRDAALAFLs--------sRSQVSHTDYVPSFNQDPSSCGE 207
XP_006141141        155 ppIPDYVAHPERWTKYSLEGVa--EASEQSNRAAALSFLg--------sRRLAAPSDYMPSFNQDPSSCGE 215
PNI26611             86 ppVPDYVAHPERWTKYSLEDVt--EVSEQSNQATALAFLg--------sQSLAAPTDCVSSFNQDPSSCGE 146
ELK13213            242 ppVPDYVAHPERWTKYSLGDVa--EATEQSNQAAALAFLg--------sRSLAVPRDCVPSFNQGPSSCGE 302
Q1LZD3              146 ppVPDYVTHPERWTRYSLDDVa--EASEQSNRAAALAFLg--------pQNLAAPGNYMPSFNQDPSSCGE 206 cattle
XP_005996133        157 saVPDYVAHPERWTKYSLEDVe--ETSDRKNKMVALEFLeglqksrekkMSLDIDKSFVPCFNQGLSSSAE 225
XP_011456531        146 qrTPDFKMNPEKWTKYSLEDVdneDMTESSNTKAAFAFLee-------rRKLREGEMKVEAVNTDNTSCSK 209
EEB18555             92 --VPDFQRNPHKWTKYSLGDVtqnEMSNETNTAAAMSFLr--------dIEIQKLKTRVKMEVDDSNDCKS 152
XP_001122509         92 --IPDFHKNPHKWKKYSLDDVsndDMTEESNTRAALSFL----------KELKARRSLEKLKQSEKIDINE 150
EDV96084             93 --TPDYQVNPHKWKKYSLSDV---DISDQTNSAAALSFL----------REMDAQHGQTDPADEMDNEPST 148
WGS:AANI:GJ12103-PA  98 --TPDYQINPHKWKKYSLSDV---DISDQTNAAAALSFL----------REMDSQRDVDSDDTEDMNDAGT 153
XP_002007559         95 --TPDYQVNPHKWKKYSLSDV---DISDQTNAAAALSFL----------RQMDAQRDADSDGTDDMDETGT 150
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