Conserved Protein Domain Family
FAM196

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pfam15265: FAM196 
FAM196 family
This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.
Statistics
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PSSM-Id: 464603
Aligned: 19 rows
Threshold Bit Score: 481.175
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007671533   3 QQSMKVRPVLLkrNSLDS---------------VDFIKApHHRRSKSQQVRFKEDGANQQPTDVGEADPqeTGNPTLTGK 67 
XP_016847692  27 MGSKESSKCLL--TTSESevdpatslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLST--LQQIDKKES 101
XP_013964370   1 MVSKETSKCVL--TTSEGevepaaclalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDAQLPA--GPPGDRREA 75 
XP_002194009   1 MVSKEPSKCLL--TASDSdvepaaslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLSTssTQDPDKREA 77 
OCA27787       1 MVSKEGDKCVL--TSSESeveqavslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLST--VPQTDKKDS 75 
XP_003756859   3 QQSMKVRPVLLkrNSLDS---------------VDFVKQpHHRRSKSQQVRFKEDGASKNQAGLAEIDVqaDQDSTLMGK 67 
XP_003268692   3 QQNMKVRPVLLkrNSLES---------------VEFVKQpHHRRSKSQQVRFKEDGTTKNPTGLAEVDVrtPEDPAVMGK 67 
Q6GQV1         3 QQSMKVRPVLLkrSSLES---------------VELVKQpHHRRSKSQQVRFKEDGNIKNPTGVTEVNTqtPEDPGVMGK 67  house mouse
XP_005995868   1 MVSKEASKCLL--TNSESevepaaslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLSA--ALQSDKKDA 75 
XP_013011652   3 QQSMKVRPVLLkrNSLES---------------VELVQQpHHRRSKSQQVRFKEDGTTKNQTGVAEVDAhtPEDPAEMGK 67  domestic guinea...
XP_007671533  68 TR-----VSRSHHPPGYSLSLPRS-RGGNirniaIQTSPSLRKHFPVF--KRKKLTASKSLLEMPTeskssiqlngnlse 139
XP_016847692 102 KSlsyraAYRKYMTVPARRSIPNVtKSTG-----VQTSPELKKCYQTFplDRKKGSIIKSIASVDT-------------- 162
XP_013964370  76 KPassraAYRKYMTVPARRSIPNVtKSTG-----VQTSPDLKKCYQTFplDRKKGN-LKGIPAADA-------------- 135
XP_002194009  78 KAisyktAYRKYMTVPARRSIPNVtKSTG-----VQTSPDLKKCYQTFplDRKKGNILKSASTVDT-------------- 138
OCA27787      76 KSls-ykAYRKYMTVPARRSIPNVtKSTG-----VQTSPDLKKRYQTFplDRKKGNILKNATGVDP-------------- 135
XP_003756859  68 VQ-----ASRHHHLPSYSLSFPRSqKGGSirniaIQTSPSLRKHFPVF--KRKKLTASKSLVEMPTesknsiqvngnlse 140
XP_003268692  68 TQ-----ATRHHHPPTYSLSFPRSqKAGGfrniaIQTSPSLRKHFPVF--KRKKLTASKSLVEMPTasqsaiqvngnlse 140
Q6GQV1        68 AQ-----ASRHHHPTTYSLSFPRShKAGGfrsisIQTSPSLRKHFPVF--KRKKLTTSKSLVEMPTaspsaiqvngnlse 140 house mouse
XP_005995868  76 KPisyktAYRKYMTVPARRSIPNVtKSTG-----VQTSPDLKKRYQTFpmDRKKGNVIKNASTVDT-------------- 136
XP_013011652  68 TQ-----ASRHHHPPTYSLSFPRAqKAGGfrniaIQTSPSLRKHFPVL--RRKKLTSSKSLVEMPTapqsaiqvngnfse 140 domestic guinea...
XP_007671533 140 qdavasdlaylsitppfgeepkrgkrahpffsrvVKVQSNGPLSVAMD------PGTLGKREKATASTQVPEEGPNSppc 213
XP_016847692 163 ----------------------------------FPSQNNGFLIDVKDkds-niSGEAAHCSKKVTGFVTAEFISHT--- 204
XP_013964370 136 ----------------------------------FKSQNNGFGPDAKDqhe-egPGEAGRPWGGGRVPKAAAPVAHS--- 177
XP_002194009 139 ----------------------------------LPSENNGFLIEVKDreg-rgSGEAAAWGRKAGSLQTAEFISHI--- 180
OCA27787     136 ----------------------------------LKNQNNGFIIDAKDk----nSGDTIQCSR-VNEQVVADLMIHS--- 173
XP_003756859 141 qdimssdlaylritrhlddvphrgkkahpffprmSKAQSNGPVSICFE------TDALGPSEKVTVSTQVPDDICHSppw 214
XP_003268692 141 qdivssnlaylrlaqhledgprrvkvshaflprvPKVQSNGPVSICLE------AGTWRSLEKATAAIQVPDDIYHSpsw 214
Q6GQV1       141 qdivssdlaflrlaqhledgprrlkiphpflprmPKVQSNGPVSFCLE------SGTWMSSEKATAAIQVPDDICHSptw 214 house mouse
XP_005995868 137 ----------------------------------FKSQNNGFVIDIKDnkdsesSGEAALCSRKVSDQKEAVLTLHT--- 179
XP_013011652 141 qdlmssdlaylrlaqhlvdgprrikvshpflpqlPKLQSNGPVSICLD------AGTWRGSEKATAAIQVPEDIYHSpsw 214 domestic guinea...
XP_007671533 214 eakvficgreptGELSSMIQP------SETSRTDGntVLPSVSEKPSSCPNATSR---VRPHCDSyQaDTHDPKSIfPKE 284
XP_016847692 205 ------------NERMNAIEQpssdncSETCKSTD--LHSCTKEPPSLQNSAASVleePDYQLHD-K-AKHHTGLL-DSE 267
XP_013964370 178 ------------DEHVDALERpaavncAEPGGGPA--EASCPDGA--LPDAPGPEpalPG------K-PRPGRATP-DTD 233
XP_002194009 181 ------------SEraa--------hdAEAWKSSD--LHSSPKEPP----PPPANlaePGEEEPArR-GRAAAARL-GSD 232
OCA27787     174 ------------SEDMDAIHPlstsncSDACKSTD--SHSCINESPTRQNPANVSleqVICHVHD-A-SKYDRGPL-GNI 236
XP_003756859 215 gtkaptysmdrpVELSNTIHPc-----ANMCPGDVngRLPSSSERPSSCLSTASG---AHSLPGR---DKTDPELLlPKD 283
XP_003268692 215 earesalspdrsAEVSNSIHPl-----DDTCPGDGrrVTPPDSEKSTSCLNATSV---ASHTPGT---EKLKPELLlPKD 283
Q6GQV1       215 earesalspessAEESNSIPAl-----ISMCPGDGqrVMTSELERMPPCSNTNSS---ASNMPGT---EKLTPELLlPKD 283 house mouse
XP_005995868 180 ------------NECMNVVDQsssgncSEGCKSNDskSHSFTTESKYLENPEDSNleeLDYQTND-K-AKHDAGPL-VAQ 244
XP_013011652 215 etr----estvsPDRLAQINNsgp-plVDMCPGDRkkILRSDLESSPSCLNATSG---ANNMSGT---GKLKPELLlPKD 283 domestic guinea...
XP_007671533 285 DSACTQPAPSSPPLKEACNpPAPLTPSS-SPSLFGDLGQSThLGSAsdwVTlSNDNQGLITLAAGNAS--KSAPSCQGEM 361
XP_016847692 268 EANLSTHGKVFKTEVASVY-LPASSSHAsQTDLQNSAAAGNdWFLC---PA-EEDKKRTVHLNGLQSQavSAAQACSMQA 342
XP_013964370 234 EAAPAAHGTLFKTEVAAVY-APAPGPRGpEAAWSNPGAPGE-RPLC---PAaEQEPRRAARLDGLRAAp-GPAAACSPPT 307
XP_002194009 233 EAAQPLHGRLFKTEVATVY-LPASQPDLpGLGDWGP---------C---PEeEEEDGRTVQLNGVQPPg-RDARACAARA 298
OCA27787     237 HSNQSGHIKVLLKEEATIH-SPTLNPNLtDPEESNPGNDSEqt-----sTSaEEETKRTAHLNGLQTQd-VHAKACTAQA 309
XP_003756859 284 TSGIKEPVPLSPPSKGTCTpSPPQTHSS-SPCFLREHRQAApPETVsdcATlSNDHKDLISLTTSNMI--KPATECWEET 360
XP_003268692 284 NSDDKDLGPLSSQSKETCVpSPPRTHSSpSP---GSHIQPAhPGRAsdcPSsSNNHQNLVSLKTNSAS--KSAPGCQEQT 358
Q6GQV1       284 NPDDKDLGLPSSQSKKMCVpSPPRTHSSpEP---GSRSQPVhLGRSsdcPAsGDNHQDLESLRSSSAS--KSVPVCWEHV 358 house mouse
XP_005995868 245 VPNQYSHSKVLKVEHATVH-LPESGSETtHPQLSNSLTETE----CsqnPAvQEEQNRTVHLNGVQSPs-VTGQVYSMQT 318
XP_013011652 284 NSNDKGLGPLSSQSKETCIpLSPRTHSCpAP---DSHIQTAhSGRAsdyPAsSDGHQNPVTLKSSSAS--KSAPLCQEKM 358 domestic guinea...
XP_007671533 362 E-------KNSTQSdapefktglesfhiQPSLPKKEIKAQTNK-EIREINQIHLAHGELCDLQGRLQSVEESLHSNQEKI 433
XP_016847692 343 Qcqs-tecNEQTLQ--------------IHVSPMEGKQPCQTAvAVSEGCQQIVPHTEVVDLKAQLQMMENLISSSQETI 407
XP_013964370 308 Qcls-pecSEQPPQ--------------TRAPPGEESQLCPPAaAAGEECRQIVPHTEVVDLKAQLQVMEDLISSSQETI 372
XP_002194009 299 Qcpa-pecSDQSLQ--------------VNVAPVEESQPCRTAvAVSQECQQIVPHTEVVDLKAQLQMMENLISSSQETI 363
OCA27787     310 QcqatecnNEQTLQ--------------INVLPAGKNAPCQIAvALSGECQQIVPHTEVVDLKAQLHTMENLISSSQETI 375
XP_003756859 361 E-------KNSSQAdplefknclgsfhlQSSLPRSEIKPPNNK-EIKGINQIHLEHGELCDLQGRLQSVEESLHSNQEKI 432
XP_003268692 359 A-------NNPTESdtlefpncpgsnhlPSSVPRSETKLQSTR-EISDINQIHLARGELCDLQGRLQSVEESLHSNQEKI 430
Q6GQV1       359 T-------KLPSQSdtpelqtgvgseqlPASIPRQENRAQSSR-EIGGSNHSHLAQGELCDLQGRLQSVEESLHSNQEKI 430 house mouse
XP_005995868 319 Hcqs-thnNEQPLQ--------------TTTLPVEDNQPSQTAvAVSEVCQQLMPHTEVVDLKAQLQLMENLISSSQETI 383
XP_013011652 359 T-------MNPTQSdilelrsrpgsdqlSPSLPNSETKYQSNR-EISGINQIHLARGELCDLQGRLQSVEESLHSNQEKI 430 domestic guinea...
XP_007671533 434 KVLLNVIQDLEKARALTEGr------------------------------NFYRTGQDLNNCSTCQNTACIIYSVEYDFR 483
XP_016847692 408 KVLLGVIQELEKGEAHREGycylgenlmsksdldyvmkasshllrldplkLSYRTGQDTSNCDTCRNSACIIYSVELDFK 487
XP_013964370 373 KVLLGVIQELEKGEAHREG-------------------------------LSYRTGQDTANCDTCRNSACIIYSVELDFK 421
XP_002194009 364 KVLLGVIQELEKGEAHREG-------------------------------LSYRTGQDTANCDTCRNSACIIYSVELDFK 412
OCA27787     376 KVLLGVIQELEKGEAHREG-------------------------------LSYRTGQDTANCDTCRNSACIIYSVELDFK 424
XP_003756859 433 KVLLNVIQDLEKARALTEGr------------------------------NFYRTGQDLNNCSTCQNTACIIYSVEYDFR 482
XP_003268692 431 KVLLNVIQDLEKARALTEGr------------------------------NFYRTGQDLNNCSTCQNTACIIYSVEYDFR 480
Q6GQV1       431 KVLLNVIQDLEKAHALTEGr------------------------------NFYRTGQDLNNCSTCQNTACIIYSVEYDFR 480 house mouse
XP_005995868 384 KVLLGVIQELEKGEAHREG-------------------------------LSYRTGQDTANCDTCRNSACIIYSVELDFK 432
XP_013011652 431 KVLLNVIQDLEKARALTEGr------------------------------NFYRTGQDLNNCSTCQNTACIIYSVEYrpy 480 domestic guinea...
XP_007671533 484 QQEGRFHQVLKTLDQVEQIPEMSPPQQVPVDPPVPEKQDiRRKSKKMKKKCFWWI 538
XP_016847692 488 QQEDKLQPVLRKLHPIEETQVAPLPYSQESYSSTPKQKS-KTESKKHGRWKLWFL 541
XP_013964370 422 QQEDKLQPVLKKLHPFEETQVAPSPYSQEPYSATPKQKS-KPESKKHGRWKLWFL 475
XP_002194009 413 QQEDKLQPVLRKLHPIEETQVAPLPYSQESYSSTPKQKS-KTESKKHGRWKLWFL 466
OCA27787     425 QQEDKLQPVLKKLNPVEESQVAPLPYPAESYTSTPKQKS-KTESKKHGRWKLWFL 478
XP_003756859 483 QQEGRFHQVLSSLDQVEPPPETALPPKPPAEPPAPEKQDlRRKTKKVKKKCFWWI 537
XP_003268692 481 QQEGRFHEVLQSLEEAEPVEEASPPPKSPAEPPAPEKQDlRRKTKKVKKKCFWWI 535
Q6GQV1       481 QQEGRFHEVLQSLEEAEPTEEAPSPPKSPAEAPVPEKQDlRRKSKKVKKKCFWWI 535 house mouse
XP_005995868 433 QQEDKLQPVLRKLHPNKETQVPSLPYTPEGY-STPKQKS-KTESKKHGRWKLWFL 485
XP_013011652 481 tsrq-nifkxmqITEIEPVEEPSSPLKSPAEPPAPEKQDlRRKTKKVKKKCFWWI 534 domestic guinea pig
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