Conserved Protein Domain Family
RHINO
?
pfam15319: RHINO 
RAD9, RAD1, HUS1-interacting nuclear orphan protein
RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.
Links
?
Statistics
?
PSSM-Id: 464642
Aligned: 19 rows
Threshold Bit Score: 239.23
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
NP_001006563   1 MPP--KKKCTRKTRKAELVFLERPWEGPIHCAET-PLYV-AENPICVSTKPVDQNTSAAWVCPQFETAKSLVLRACQ--K 74 
XP_010715565   1 MPP--KKKRTHKTRKAELVFLERPWEGPIHCCET-PLYV-AENPVCVSTKPVDQNTSATWVCPQFETTKSLVLRVCQ--K 74 
XP_016160486   1 MPP--KKKCTHKARKAELVFLERPRAGPIHCYET-PLRS-AENPRRVPTKPVDRNTSAVWVCPQFDTTKSVVLKACR--K 74 
NP_001314963   1 MPRtsHKKRLLNPLKSQLLFKEAPINGPKHEYGA-QLRS-AIHPRSFISEK-QQRGDAPWVSPQFNSHATTRVSRGGrgK 77 
XP_007662718   1 MPP--GKKSRRPIPRAQLLFREAPLEGPKHPYGS-PQPT-DTRPRPVPTKPIDRKTATSWVIPQFEGSTGGRRPARQ--- 73 
XP_007503833   1 MPP--RKKCKGQPRKSQLVFREGPLDGPMHPYGS-PQLA-AALPRHAPIKRIDHKTITSWVSPQFKNTVEAWLPVYP--K 74 
EHA99825       1 MPP--KKGRGQPSHKAQLLFHQQPLEGPKHHCGSvKQRLtRTRTRQGPGKPID-GAIASWVSPQFDTTVESFFPGHQ--- 74 
XP_013000604   1 MPP--KKRR---SNKAQLLFHQQPLEGPKHHCESvRQR--ATHTVQVPSKPTD-QAFASWVSPQFDTTVDSLFPARR--- 69 
Q1LZE2         1 MPP--RKKRRQAAQKPQLLFHQQPLEAPKHRCRF-PQLPvVTHTRQVPSKPVDHNTITSWVSPQFDTTAESWFPGKR--K 75  cattle
ELV09173       1 MPP--RKKRRQCSQKAQLLFHQPPLEGPKHHCAS-PRRP-VTHTRQVPSKPIDRSTVTSWVLPQFDTTAESWVPAHR--- 73 

NP_001006563  75 KQHgshkaQNQdvsydllhAERA-----CRRAVAYKFPPLIFENSEVRAVHSTDVLSHTGK---NTQHSHRQC-KGIGSK 145
XP_010715565  75 KQHgshklQNQdvnygllhAETA-----CRRSVACKFPPLIFENSEVCSVHSTDTLSHAGK---NTQHSHSQFkKGIGSK 146
XP_016160486  75 KHRgphkpYNQnanhssfhAGG-----------ACRFPPLTFENPEGHEFPPLDDPNRSRK---NAQCSHNQPkKGTAAN 140
NP_001314963  78 RNHqvatrITN--------KASAlclpqTRKASVSRFTPLSFQATTIQ-GLENLRHPQTKKntfVSSDKHQKElQETPRR 148
XP_007662718  74 RPP-----RDP--------VGNS-----GRKPHPCKFLPLAFAGLQGPCREQAPTSPPAVKrpgRASQSPTRArVRAGRQ 135
XP_007503833  75 QQQmpynlRNL--------AKGS-----SRKVTKNRFPPLSFESSESSSSEATLDSL-------SVTKCPMQHpKDTTQR 134
EHA99825      75 KHH-----QDR--------ARLS-----SRKST-CKFPHLVFENPLFSSSPEIPEIP-------SVKECRSQSeKDISRQ 128
XP_013000604  70 KHR-----RDR--------ARLS-----SRKST-CKFPHLSFESSKSSSRPEIPAIP-------LVRECLSRSeRDVSRQ 123
Q1LZE2        76 HHH-----RDH--------ARRS-----SRKSTSSRFPCLTFETPQSSASSATPGIL-------ASRDGPSQPeKDISGR 130 cattle
ELV09173      74 KQH-----RDQ--------ARRS-----CRKSSSSRFPHLAFESPQSACSSETPRVP-------LIRGHPNPSvKDASRR 128

NP_001006563 146 ANFQVNGSENCSEt-----------------------------SSLPVSLPvePEVLSPPDMGMPQWPslgnWTCSSALS 196
XP_010715565 147 ANIQVNGSENCSE------------------------------TPLSISQPvgPDVFSPLGTGMPQLPslrnCTCSSALP 196
XP_016160486 141 ANFQVKSPENCGEp-----------------------------AP----QPveQEVLCPPDAEATQVPpprnVGCSDTPP 187
NP_001314963 149 SKCA----RKCTEkrmltrvksatskytevsksltfhnngkglTNALIQTPntSLVPDPPHVETPEVP-----NCSSISP 219
XP_007662718 136 PLVPMFSPQSCGHl-----------------------------SGREPASP--GFAFLPPDIQTPEMP-------SGRGP 177
XP_007503833 135 PLVPVFSPQSCGEl-----------------------------SPHDLQTP--GYMFIPPDIQTPEQSp---VRNSGQIP 180
EHA99825     129 PLVPMFSPQTCGEl-----------------------------SAHALQSL--PCVFAAPDIQTPGPS-----VREDSSP 172
XP_013000604 124 PLVPLLSPQSCEEp-----------------------------SAHVLQSS--LCVFPAPDIQTPGPS-----EREDPSP 167
Q1LZE2       131 PLVPMLSPQSCREl-----------------------------SAHTFPDF--PCVFIPPDIQTPESP-----GQGEPIP 174 cattle
ELV09173     129 PLVPMLSPQSCGEl-----------------------------SEQPLPSF--PCLLIPPDIQTPGSSp---ATKST--- 171

NP_001006563 197 QISSHA-----ELVSSISHCGRGQMAATLVMDTPEREYGIKVTWRHRPHILKYLRDRGKLSTADITV 258
XP_010715565 197 QISSHA-----ELVSSVLHCGREQLAGTLVMDTPEREYGIKVTWRRRPHLLKYLRDRGKLSTADILV 258
XP_016160486 188 Q-SSHAwhpenELALGTDPCGRGEAAAVLVTDTPEHEYGVKVTWRRRPHIMKYLREQGKLSAADILV 253
NP_001314963 220 SNVQQLifp----psQAKTPPRAENTSVLVEDTPEKDYGLRVTWRRRKGLMKLLIDKGQL------L 276
XP_007662718 178 EDPEPSprpfgGLLSHSSPPEDSGPGPTLVLDTPEESYGLKVTWRKRRHLLAYLRERGRLSQSQFLV 244
XP_007503833 181 TAHRQHmkrscPL--LMDPPKSPDPGPVLVADTPEENYGLKVTWRRRYELLTYLRKRGKLSMSQILV 245
EHA99825     173 PEQRENslpvcV---HTCAPHSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFEYLRERGKLSRSQFLV 236
XP_013000604 168 PGQGENsppvcV---YSPTPDTPDPGPVLVKDTPEEKYGVKVTWRRRRHLLVFLKERGKLSRSQFLV 231
Q1LZE2       175 SELRENslpscSL--HTSTPKSPEPGPVLVTDTPEEKYGIKVTWRRRRHLFAYLRERGKLSRSQFLV 239 cattle
ELV09173     172 PDQRENrlpscSL--HIRAPSSPEPGPVLVKDTPEEKYGLKVTWRRRQHLLTYLRERGRLSRSQFIV 236
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap