Conserved Protein Domain Family
TALPID3
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pfam15324: TALPID3 
Hedgehog signalling target
TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.
Links
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Statistics
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PSSM-Id: 434634
Aligned: 8 rows
Threshold Bit Score: 1407.33
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007251982  138 DVHISRYSADGRGAVAAALKQRSHGAPQRREVKVQFLDSGSLHSSeFRGPEVQPSPAfpsgDVGGTSTVAAITAAAIAAT 217 
NP_084094     117 DIFISQYTMGQKDALRTVLKQKAQSMPVFKAVKVHLFEDTSTEKN-TVAQETETPPN----RIDSATTVAAATAAAIATA 191 
Q9BVV6        101 DIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKD-AVTQETRISPS----GIDSATTVAAATAAAIATA 175  human
XP_013010722  115 DIFISQYSVGQKDALRTILKQKAQSIPIFKEVKVHLLDDAGVEKV-AAPPEARGSPS----GIDSATAVAAATAAAIATA 189 
XP_012403948  132 DIFISQYTTGQKDVLRAVLKQKVQHSPTFKEVKVQLLKDACMVKD-PISVEKKLSSN----GIDSPSTVAAATAAAIATA 206 
XP_008118497  127 DIFISQYDAGQKEAVRAVFKQRVQNAPVFKEVKVQLLGNTCSNKK----DSPKSSHS----EMDSAATIAAATAAAIAST 198 
XP_015205600  119 DIVISQYSVGGKEAVRAVFKERCRSAPVRKAVKVQLLEPQEP-------PPAGPPPP----QPCTADTVAVVTAAAIAAT 187 
H6D7E6        126 DVQISTFSADGRGVVSAALRKRSQGAPIRRNVTVQVLDQDRSQTP----AGVQPDPAfplgDPGTSASVAAITAATLAAT 201  zebrafish

XP_007251982  218 APLIKAQSDMEARMAQVASELRRLQESEGRTDRSAESRATSDA-----GRVTQL----EVQLTALTQQRLQHLERIQGQQ 288 
NP_084094     192 APLIKVQSDLEAKVNCVGELLTKLQETDKQLQRVTEHQASVQSkq-ekVHCHDH----DKQMNAFMEQHIRHLEKLQQQQ 266 
Q9BVV6        176 APLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRkq-ekLHCHDH----EKQMNVFMEQHIRHLEKLQQQQ 250  human
XP_013010722  190 APLIKVQSDLEAKVNSVTELLNKLQETDKHLKRVTEQQTSIQNkq-ekLYCHDH----EKQMNVFMEQHLKHLEKLQQQQ 264 
XP_012403948  207 APLIKVQSDLEAKVNSVSELLSKLQETDKQLQRVAEQQKNIKIqp-ekSCCQDH----EKQFDVFIEQHLRRLEKIEQQQ 281 
XP_008118497  199 APLLKVQSDFEAKVSSVSKILNKLQETDRRLQLAVERQSSLKAptrerSPCHQRfgelEKQMHLFMEQRLRNLENFQQQQ 278 
XP_015205600  188 APLLKAQHDLDTKISSVSELLKKLQHVERQ------------------PCQEERvaelEKQLAALTHQRLQHLEQIQQQQ 249 
H6D7E6        202 APLMKAQSEMEAQISRVSAELKRLQAAEGSVPPGRTARTDSSS--------AGRaahlEEQLNILIQQRLQHLETIQCQQ 273  zebrafish

XP_007251982  289 LELQNRLLGSALTAVTagtIPPSQSTH---------Hs-----nSGETHSDSVQRAFNSH---KCAAEDSSTVVqdq--- 348 
NP_084094     267 IDIQTHFIDAALKASS---LQLGMSTSrav----gkY-------SGKLGSPSVGSSVFSHn--TFVSKRVPLSE------ 324 
Q9BVV6        251 IDIQTHFISAALKTSS---FQPVSMPSsra---vekY-------SVKPEHPNLGSCNPSLy-nTFASKQAPLKEv----- 311  human
XP_013010722  265 IDIQTHFISAALKTNT---FPPASTLApra---mekH-------SREPGCPFVGGSMLSSh-ePFASKQATLRKv----- 325 
XP_012403948  282 VDIQNHLIASAFNSGR---YQPVIVPSsnp---vekSf-----vKSELQCP-VGSNYTSHhrcTELPSQAYLRQv----- 344 
XP_008118497  279 MNIQSHLISSALNPGG---LQAASTAA-----------------SKETTKPTAGRSLASQ---TSPPQDLLAARavhmqa 335 
XP_015205600  250 LELQTRLLGGALSAVSgssAPAPPVSShlaa-paqpGlqrlpgnASRDESPAGAPASTSTaaaGCPPPRVPAAE------ 322 
H6D7E6        274 IQLQNRLLGSALDVVAs--RGNSSGVSqtdslplqiSgnrsirlSATDNPSAGRPASVSMdv------------------ 333  zebrafish

XP_007251982  349 ----srETRAGREKSPLETPAPRKVIPRPTHWNPALQDS----QQGSS-KGRKATH---KSHGNGRLLEQIPNNQRSPTR 416 
NP_084094     325 ------DTDFDGQKSPLETPAPRRFAPVPVSRDGKITKR----ESPTEeKENMEMN---SPKGNVRLLEQVLNSNECLTR 391 
Q9BVV6        312 -----eDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKR----ENLLEeKENMEVS---CHRGNVRLLEQILNNNDSLTR 379  human
XP_013010722  326 -----eDTYFDEQESPLETPAPRRFAPVPVSRDGEMPKR----ENPMEeKENMEKS---DYKGNTRLLGQILNNNDSSTR 393 
XP_012403948  345 -----kDLGFDNQKSPLETPAPRRFAPVPVSKDDKISKN----AKPREeKENLQIL---SCTGNGRLLEQILNSQDTQVK 412 
XP_008118497  336 csrpfgSHAVHRQKSPLNTPAPRRYAPVPVSRDAKISQKmskrEPPVGeKENMHQPaygTTVGGGKLLEQILNSQETPAS 415 
XP_015205600  323 -------------TSPLETPAPRRFVPVPMSRDAAARRSq---EKPAVeKSKVAS----GRLGSGRLLEEILNTQ----- 377 
H6D7E6        334 ----yrERQTGGHKSPLETPAPRKVIPKPTHWTSSTSTN----RPPKSsFKN---------QGNGRLQDQSPNNRRSPER 396  zebrafish

XP_007251982  417 YPAHTVgVRGVAIATVD-SQPEQSRENQPEA-FIFSTGRprpeesadaltkpsskqhiqaglkdvnpltdgAPESSTSAV 494 
NP_084094     392 KTESSD-ITSLTQPKMG-WNLEKRDSTETLHsQIFPSSE--------------------------------ERGTAQVPV 437 
Q9BVV6        380 KSESSN-TTSLTRSKIG-WTPEKTNR--------FPSCE--------------------------------ELETTKVTM 417  human
XP_013010722  394 KSESSD-ITSLSRSKLG-WNPERRHSFEALSsQRFPSSG--------------------------------EPGTAIVTV 439 
XP_012403948  413 ESTSSE-GVSLATSRIK-QDPLRDSGVAPLKpNSFPSHE--------------------------------EFGIAEKTM 458 
XP_008118497  416 QDTYSL-KESSGNNAVL-WPFERECRSSVQEpEPFCAFKst----------------------------nqNLNPVERTV 465 
XP_015205600  378 -GLQSArGRSVTMATGG-SYTERNSCSRKAE------------------------------------------EAASAAV 413 
H6D7E6        397 CALQSVgVERFAMATADnSQPEQSRESQMPSkASVTRSAqedgssfvngq-----------neqerqgeptNVSSSSTTV 465  zebrafish

XP_007251982  495 QQAAAMLQDLSRiKNEMRSLLrtadafpvk--------------saeasrssRSSRHALPSTTPPPPpvppvsmqg---- 556 
NP_084094     438 PKYNDVVHDLGQ-KKQASDML-------------------------------QIKQSPVTLRLSDHP------------- 472 
Q9BVV6        418 QKSDDVLHDLGQkEKETNSMV-------------------------------QPKESLSMLKLPDLP------------- 453  human
XP_013010722  440 QKPNDVLQDLGQkRKETNSVL-------------------------------Q--------------------------- 461 
XP_012403948  459 RHTDDVFYDLGRrKKE-------------------------------------PEESLNTVRVDDLP------------- 488 
XP_008118497  466 QKAGDVLRDLGQlKREMHDILqdakewksdmnkfmkttahpgeaiqakdrlpQSQSSSSLLPSSEAFlpmpppaenytva 545 
XP_015205600  414 KKASDVLRDLGQlKTEMQSLLqegkewrsnleqqskvpevfplewsrqarpnRGPAASDPPPPPPPPppaplegslh--p 491 
H6D7E6        466 QKASEMLQDLGRlKNEMRSLLqtadafpvp--------------nakstqssR-SRHLAPVATAPPPatapismppepvd 530  zebrafish

XP_007251982  557 dtvtsgaarAHPTVLQNSQpPASMFEDAGLVLRQVRHSRKVLEENLQAVLRAKDGEALHTQLEALSNNRDASEELRIKKT 636 
NP_084094     473 ---------HNPALLQTTN-TRSVLKDAAKILRGVQNNKKVLEENLEAIVRAKDGAAMYSFINALATNREMSEKIRIRKQ 542 
Q9BVV6        454 ---------QNSVKLQTTNtTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKT 524  human
XP_013010722  462 ----------SSCKLQTTN-TRSVLKDAEKILRAVQNNKKMLEENLEAIIRAKDGAAMYSFINALSTNREITEKIRIRKT 530 
XP_012403948  489 ---------KSPKHLKSTKtARSILKNAEKILRGVQNNKKVLEENLEAIIHAKDGAAMYSFINALATNREMLEKFRIRKA 559 
XP_008118497  546 ptlrelqqlSKSSILQSTQaSKSILRDAEKILRAVQKNKKLLEENLEAIIRAKDGNALHAFIDGLTADRDVLEEIRIRKT 625 
XP_015205600  492 lksaslpqsSDPMVLQKTKaPKSMFEDAEKVLRQVKQHKKVLEENLEAILRANDGAVLHSQIEALSSNRDASGEIRIKKT 571 
H6D7E6        531 viavraaalNRASVLKSIQpPTSMFEDAGLVLRQVRQSKKTLEENLEAILRAKDGEVLHTQLEALSKNRDVREELRIKKT 610  zebrafish

XP_007251982  637 VDAWINTLSKDIQNELVHPGsaaqskgverisgaaagstvqrdqssrsrntpgtgrGSVKIGRGGKRATAVAAAAtatev 716 
NP_084094     543 VDEWIKIISAEIQDELMRKD------------------------------------YEQKRFDPKNQRNKKALTM----- 581 
Q9BVV6        525 VDEWIKTISAEIQDELSRTD------------------------------------YEQKRFDQKNQRTKKGQNM----- 563  human
XP_013010722  531 VDEWIKAISAEIQDELARKD------------------------------------FEQRRFAQKNQRTQKAQIM----- 569 
XP_012403948  560 VDEWIKIITQEIQEELSRKD------------------------------------YEQKKFD-KNRRSNFTKKAlnnqy 602 
XP_008118497  626 VDEWIKAISMEIQDEMERTD------------------------------------SLKRQQASQMARTSREIMG----- 664 
XP_015205600  572 VDEWIGTISKDIQAEIARKDf-----------------------------------VSQMKGKDKEAATVSSQKGqgakg 616 
H6D7E6        611 VDAWINTLSKEIQDDLARESseri----------------------------vdaaVSRREAGQRTRAEA-SAAAkktsv 661  zebrafish

XP_007251982  717 arrRQQGRAEAASTQPSNQHLS----SSLRNSAEEHPQASVVP-------------------QSEDDEAYLAKIYGKALY 773 
NP_084094     582 ---SRDIKANNQEKTVNRSVIPr---SHYQKQTQEQFTSPPVRnlpasgpqk-ersgllksaTTLQDEDYMLQIYGKPVY 654 
Q9BVV6        564 ---TKDIRTNTQDKTVNKSVIPr---KHSQKQIEEHFRNLPMRgmpasslqkerkegllkatTVIQDEDYMLQVYGKPVY 637  human
XP_013010722  570 ---SKDIKANTQDKTVNKSVIL----KKPQKQVEDYFRSPPARsmavsslqkerkagplkspTMIRDEDYMSQVYGKAVY 642 
XP_012403948  603 qktSKEIKISAQDKNLNRFGFPg---KHFRKQLEESYRNTYLQnicisnldknrkeghlkttKVAQDSDFFLQIYGKPAY 679 
XP_008118497  665 -------KSHYPSKVPTKRPLPa--tKPIQRLTDKVLPKTRLE---------------------LHNEDFLSQVYGRPIY 714 
XP_015205600  617 irqQRDVKNAAQSKLITAARKPlntsKPFRKAAEGHLEKPNVQsksfshflq--kkepilkgQELEDEEYLQRVYGRAVY 694 
H6D7E6        662 raqAGNTRAHTRQPAPAVRNKP---------AVKQEATQPIVL-------------------KSQDDEEYLARLYGKAIY 713  zebrafish

XP_007251982  774 EGHRRTLKKGPYLRFSSPSPKSKGHRPKVIESVKGVKMKSSKTQTSMSGAQDPSS--LLQPAV-----PGTQYLFSPSGP 846 
NP_084094     655 QGHRSTLKKGPYLRFSSPSPKAKPQRPRVIELVKGTKVKSAKTQTDFHAASRMKMdsKIQHPItalphADQQYMVSPSRE 734 
Q9BVV6        638 QGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMdsKMKHSVpvlphGDQQYLFSPSRE 717  human
XP_013010722  643 QGHRSTLKRGPYLRFNSTSLKSKPQRPKVIEQVKGTKVKSIRTQTDLHATKPMKTdsKMQHSIpalphGEQQYVFSPSRE 722 
XP_012403948  680 QGHRSTLKRGPYLRFNSPSAKSKPQRPKVIEQVKGTKVRSTRTQTDLEMTRPVRTdsRKPHSCslpthQEQQYLFSPSRE 759 
XP_008118497  715 QGHRSTLKRSPYLRFNSPPPKSKPPRPKVIESVKGTKVKSARTQTSDH-VHSNATrpDKPHLSta-lrQELQYLFSPIKE 792 
XP_015205600  695 QGHRSTLKRAPYLRINSPSPKSKPQRPRVVESVKGIKVKSARTQTGLFPPKKTDSrpAGQPFS-----HELDYVFSPSRD 769 
H6D7E6        714 DGQRRTLKKSPYLRFNSPTPKSKPQRPKIVETVKGVKMKSSKTQTSQY----VGDvsAMQHSV-----SEPHFIFSPSDP 784  zebrafish

XP_007251982  847 VQQQqqqpGCSVPGFLIPMAIPLGKPKVDGQAPLPSRVIISD-KPATVITSFTPAVt--PTVVPSVRKPNTVLLEVQSEQ 923 
NP_084094     735 MPTV----SGTLEGHLIPMAILLGQTQSNSDSMPPAGVTVNKpRPVTVTTSIPPAS---RKGNAGVKKPNVAIVEMKSEK 807 
Q9BVV6        718 MPTF----SGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKpHPVTVTTSIPPSS---RKVETGVKKPNIAIVEMKSEK 790  human
XP_013010722  723 MPTF----SGTLEGHLIPMAILLGQTQSNSDSLPPAGV-VHKlHPVTVTTSIPPSS---RKVETGVKKPNIAVVEMKSEK 794 
XP_012403948  760 MPSV----SGTLEGHLIPMAILLGQTQSNSDSMPPAEAVVEKpHLVTVTTSIPPSI---KTKPTGPKKPNTAVIEMTSEK 832 
XP_008118497  793 GPSS----SGPLEGHLIPMAIPLGQKQIDSIPPQPAGKSIGEfHPLTVTTSVPPSHpplQKPEPKAKKPNIAVIQMRSEK 868 
XP_015205600  770 VPSTgi-rSAPLEGLLIPVAIPLGVPRLDGAAPQPSSVTTVQkQPVTVTTSVPPCP---PKPPAGARKPNVALLEMRSEK 845 
H6D7E6        785 DKQQqq-pGSPVRGYLIPMAIPLGKPRVDCQPPVPSRVIITD-KPAIVTTSFPPITvveSKPTPAIRKPNAILLEVQSAP 862  zebrafish

XP_007251982  924 RRPtPQLQIQVQPSVNIESV------TAPSPdlCPPLHITPPDIQAGADTRSLGEEDEEDddDGFPGTKFLAVADILQEP 997 
NP_084094     808 KDP-PQLSVQILPSVDIDSVsysstdGASSP--PSPKEASLPPLHTWIQTPDFMKVDEEE--VPLPGTNFDEVIDVIQEE 882 
Q9BVV6        791 KDP-PQLTVQVLPSVDIDSIsns-sadVLSPl-SSPKEASLPPVQTWIKTPEIMKVDEEE--VKFPGTNFDEIIDVIQEE 865  human
XP_013010722  795 KDP-PQLTVQVLPSVDIDSVsns-sapSSLPflSSPEGAPFPLMRMCTQSPEFMKANEEE--VKFPGSNFDEVIDVIQDE 870 
XP_012403948  833 KDP-PQLTVQVLPNLDIDTLsnesadENQAS--TNCIEASHP-TQTWIQVPELNQPDEDE--PKFPGSNFDEVFDVIQDE 906 
XP_008118497  869 KDP-PKLTLQVLPSVDIDSIssgsrsVNQASstSLP--------EKAMSSPDGSLLQDED--LHLPGAHFDG-TDVSQDE 936 
XP_015205600  846 KDP-PTLTVQVLPSVDINSVss---------esPAPS---PPLAQPNIQTVEQAQTQEEDs-NEFPGTDYVAVTDIAQDS 911 
H6D7E6        863 KKRtPQLQIQVQPGVNIESAlcssrqASPTPviPAESILPPPSIHATEDPHA--HEDQQE--NIFPGTNFLAQADISQ-- 936  zebrafish

XP_007251982  998 EVDE-EAPE--EAPIELNGLPSPPAALYHGPAFPLEPRQTGPLTEPILSTIQQRETLENRLVDWVEQQLMARMISGMFPQ 1074
NP_084094     883 EKRD-EIPEcsAPMLEFNRSVKVVPTKYNGPSFPPVVSAYHPTTDILDKVIERKETLENSLIQWVEQEIMSRIISGLFPL 961 
Q9BVV6        866 EKCD-EIPDs-EPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPV 943  human
XP_013010722  871 EKCD-EIPEysEPILEFNRSVKVVSTKYNGPPFPPVLSTAQPTTDILDKVIERKNTLENNLIQWVEQEIMSRIISGHFPV 949 
XP_012403948  907 EKSD-DIEDffEPVLEFNQSAKVIPQHYNGPPFPPVVSAAQPTADILEKVIEKKEALENSLINWVEQEIMSRLISRMLPF 985 
XP_008118497  937 GVEDfGIPEfaEPVLEFNRQGETESPKYNGPPFPPAVPVPQVSSDVLDEIIEKRETLENKLVDWVEQEVMARIISGMYPT 1016
XP_015205600  912 EEED----GlsEAAIEINGQVGPALAPYHGPSFPPSAPEPRPTIDAVEVRIQQRETLENRLVDWVEQQLMARVIAELYPP 987 
H6D7E6        937 ETNG-GLP---DSPIEFKGLPSPPADLYHGPVFPPVPTQSTPLTEPILNTIQQRETLENRLVDWVEQQIMARVITGMFPQ 1012 zebrafish

XP_007251982 1075 PAQTDPAN---QSEPDDSVTSDIVETAGGGGLQLFVDAGVPVDSELIRQYVNEVLAEIITLMLGQREGPREPA--APASI 1149
NP_084094     962 QQQARLDAsvsVSEASEPSASDIVAGTSSGALQRMVDARVPVNSDMVSHFVNEALTETIAVMLADREAERQRA--AATSV 1039
Q9BVV6        944 QQQIAPSIsvsVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGP--VATGV 1021 human
XP_013010722  950 PSQTKLPAsisVSEASEPSTPDIVEGTCGGALQLFVDAGVPVSSGTIRRLVNDALAETIAGMLGDRESKKESP--VAAGV 1027
XP_012403948  986 QPQTVPNVsvsESEESETSASDVVEAAGGTKFRLVVDAGVPVNSDMINLFVNEALEEIIAIMLGNKEITKDVP-----PL 1060
XP_008118497 1017 QKEAVPDLnasESEHSEAVSSDIVEAAGAAGFQLFVDAGVPVDSEMIRRFVNEALAETVATVLGDRENHRAAPvtVVPSA 1096
XP_015205600  988 RVQAAEDSgasELEDSGASTSDIVEAAGGGGVQLFVEAGVPVDSELIRQYVNDALAETIAIMLGQREGQRPAS--PPAAL 1065
H6D7E6       1013 PAQADPVH---QSEPENSVASDIVEAAGGSGLQLFVDTGVPVDSEVIRHYVNEVLTEIIASMLGQREAQGTPA---TLVQ 1086 zebrafish

XP_007251982 1150 RDTLPRQKTPVP----TPVPTPEPSVRGS-PpVLREALSPISTPDLSEQPSPVQ---SRRDSQPEQPQ---PtSP---E- 1214
NP_084094    1040 PGDLSGTETNLLarvcAPVATPQPTPPCS-P-SPVREHVRVKTPDSSPCESDPDaasSIKEIRVEKGS---D-MP---Av 1110
Q9BVV6       1022 SGDASTNETYLParvcTPLPTPQPTPPCS-PsSPAKECVLVKTPDSSPCDSDHDmafPVKEICAEKGD---D-MP---Ai 1093 human
XP_013010722 1028 PGDVSTSETLLLtricTPVATPRPTPPCS-PsSPPKECVLLKTPDSSPCGSYHDvtfPVKEISAEKERsvgQdIP---Av 1103
XP_012403948 1061 PANVPDNVTYLPtvhhTPVPTPQPTPPQSpPpSSLKEPLLIKTPEASPCVSEHDi-fPVKEQFTQTGT---DnLP---As 1133
XP_008118497 1097 AALLPEKETLLP----TPLATPEATPPQS-PpPALNEQFPVKTPTSSPSVTEMDgeqP-------------QtGPeaaAa 1158
XP_015205600 1066 EVPAPPKEPVVP----TPVPTPQLSPHPS-PpPSGRAPSPVRTPDVSERESAAEf--SEAELEPSAPV---HtEPeeeHk 1135
H6D7E6       1087 TQDAQKEDTTVP----TPAPTPEPSLKD--Pp------SPVRTPDLSEHLSTA----TSPEKPPQESA---SpGP---Dr 1144 zebrafish

XP_007251982 1215 -PAKTPVGTPLSSPRRIAT-PSPPS-----------ELAGPhnHPWGNSELPLKEEEPHSEEEE-NQPkPLNVLSVAr-E 1279
NP_084094    1111 mLVSTPTRTPVATPPPAAA-LTPTLsetsidklklsSPELP--KPWDSGDLPLDEENPNSLQEL-PHP-RAVVMSVA--N 1183
Q9BVV6       1094 mLVNTPTVTPTTTPPPAAAvFTPTLsdisidklkvsSPELP--KPWGDGDLPLEEENPNSPQEE-LHP-RAIVMSVAk-D 1168 human
XP_013010722 1104 tLVNTPSVTPTATPPLAAA-LTPTLsetsidklkisSPELP--KPWGDRDLPLDEENPNSFQEElLHP-GALVMSVAk-D 1178
XP_012403948 1134 tLIITPTVTPAATPPLAGT-PTLTLsenssenlkrpSPKFP--KPWSTDDLPLDEENPNPIQEEvLHP-RAIVMSVAr-D 1208
XP_008118497 1159 sVVYTPVATPVATPPKIAT-PTPPVserapnreameKPPPP--NPWEDAELPLEEEKPSPQSEEgAYPsRAVIMSVAk-H 1234
XP_015205600 1136 sPVITPAATPIPSPHPVAT-PSPPEpern----pspEPARPlpSSWEDAQLPLEEEDPRPDREE-QQSqRAVVMSVAq-E 1208
H6D7E6       1145 iPVGTPITTPIPSPTRVAT-PSPPTpan-----qspEPGSLqiHLWEGSELPLEEEE----QPE-LQP-APVVISVPrvD 1212 zebrafish

XP_007251982 1280 EDEEAVLPPS--SPVLSKPLSPPvsAVKEAPP---APP--------ESPSVEESSSQVSPSl-TETETETAARHISEGEL 1345
NP_084094    1184 EEPESVDFSAqpAPPEPAPSAPL--PEGTKAP---SLQ--------RVPSSGSSTLENTLS--TVTETETLDRHISEGEI 1248
Q9BVV6       1169 EEPESMDFPAqpPPPEPVPFMPF--PAGTKAP---SPS--------QMPGSDSSTLESTLSv-TVTETETLDKPISEGEI 1234 human
XP_013010722 1179 EEPRSMDSPAplTPAEPPPLTQL--PVCAEVP---ASL--------QVLSSSSSTLESTLSl-TITGMETLDRPISEGEI 1244
XP_012403948 1209 EEPENLVLPIpsSSPNPIIFRSF--PLEARVP---SPV--------NTPSSDQMTQESSSSyvTTTETETVERPISEGEI 1275
XP_008118497 1235 EEPDSLVLPA------SVPIAPQ--DLQSQEPrarSPSv-------QSPSSGPSTEESl----TTTETETTDKPISEGEV 1295
XP_015205600 1209 EETVSLVTPS-------PPVAPQ--APTPTPP---PPLqapptateTPPPPTPSTEDSSSTa-SVTETDTAGRNISEGEL 1275
H6D7E6       1213 DQEESVIHPS--SPVLSKPQSPP------APP---LPPviqksessSSSSSSSSESSCSSSv-TVTETETAARHISEGEL 1280 zebrafish

XP_007251982 1346 LLSTGQMAAVRALEEegFNVPNLMTSFNSSLHGVQDMDYDPPSEGQV-IRRPVVSAHHDPILSLLARMEQGPVSQAQqre 1424
NP_084094    1249 LFSCGQNLATKRPGD--LFLMNINDSLSSTLQDALEMEDDPPSEGQV-IRRPHKKRHEDAIVALLTKQQRELLVSQQ--- 1322
Q9BVV6       1235 LFSCGQKLAPKILEDigLYLTNLNDSLSSTLHDAVEMEDDPPSEGQV-IRMSHKKFHADAILS-FAKQNQESAVSQQavy 1312 human
XP_013010722 1245 VFSCGQRLAPGILEGgeLYLTNLNDSFSSTLHDALEMEDDSPSEGQV-IRIPHKNFHTNEILPLLAKQNQELQGSQQavy 1323
XP_012403948 1276 LFSYGQKMATRDTSDggLFLNNFNDSLSSTLHDAHEMEDDSPSEGQVmMKRPHKEYHQDIFLSLLAKLNHGSLDSQQvvy 1355
XP_008118497 1296 LYSYGQLLAVKALAEggLSLPNLSDSLASSLHDAQEMDYDPPSEGQV-LRRPHKGYHRDTVLSLFSKLNQAPLASQEeic 1374
XP_015205600 1276 LFSYGQLAAARALAEggLTLPNLSASLSSSLHGFQDMDYDPPSEGQV-IRRPDIQHHRDPVLSLLARMNQGLTALQEghv 1354
H6D7E6       1281 LLNHGQMAAVRVLEQegVLLPNFMTSLNGSLHGVQDMDYDPPSEGQV-IRAPHLPAHHDPVLSLLARMELGPISQSQq-- 1357 zebrafish

XP_007251982 1425 rYW---DEESS-GEVSEGQRPPLTTAQEkvvTG 1453
NP_084094    1323 -EE---DLDNSvGELSEGQRLVLKAAED---IS 1348
Q9BVV6       1313 hSE---DLENSvGELSEGQRPQLTAAAEnilMG 1342 human
XP_013010722 1324 hSE---DLENSvGELSEGQRPRLTAAAKhvfLG 1353
XP_012403948 1356 hSE---ESENStDELSEGQRPRFPAAKEnifMR 1385
XP_008118497 1375 rSE---NTDDSaGELSEGQRPRLTRTAEsilMG 1404
XP_015205600 1355 hPQihsDDDSSmGEVSEGQRPRLPAAGEtllTG 1387
H6D7E6       1358 -PEgwwEEESS-GEVSEGQRPVLTAAEEivlTG 1388 zebrafish
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