Conserved Protein Domain Family
LIME1

?
pfam15332: LIME1 
Lck-interacting transmembrane adapter 1
LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localizes to lipid rafts in T cells in response to TCR stimulation, and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2. LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation.
Statistics
?
PSSM-Id: 464652
Aligned: 8 rows
Threshold Bit Score: 314.991
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EDL88722      27 LCTACHR--------KRAQRQQTGLQGSL--MPVEVPLLRQAHLCSLSKSDTRLHELHRGQRSTIAPRPASMDLLHPRWL 96 
XP_003317116  27 LCTACRRpedavaprKRARRQRARLQGSA--TAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWL 104
XP_021582099  27 LCTACHR--------TRVPRHRARLQGSM--MPVQVQ-VRHQAAGAVPR-----------PTQQHPPRPASMDLLRPHWL 84 
XP_008535515  13 asqdgatgarspscplgpgvpcpaplavgavrslPQSLLRRPHLCSLSKSDTRLHELHGGPRGSRALRPASMDFLRPQWL 92  Przewalski's horse
XP_025326502  27 lCTACHR---------KR---AQRQQPPGrvMQAEALLLRRHPLCTLSKSDTRLHELHRGPggcrVPRPVSMDVQRPQWL 94  dingo
XP_006104271  27 LCAACHR--------KQARRQPAGLQGTM--MPAEMSLLRQPPLCILSKSDTRLHELHQGPLHRTAPRPASMDLLRLQCL 96  little brown bat
XP_023367802  27 LCTTCg--------rKRGQRRCARLQGSV--MPAEAALLRQTQLYSLSKSDSRLHELHVGPQGCRAQRPVSMD-LHPHWL 95  small-eared galago
XP_017913004   1 -mslppwaddplaprKQARRQLSRLQGSA--MPAEVSLLRRPHHCSLSKSDTRLHELHRSRPCSRAPRPASMDLLRPQWL 77  goat
EDL88722      97 ELSRGSTRSQVPNSAFPPRQLPRAPPAAPAtpPSTSPEATYSNVGLAAIPRASLAA---------------------SPV 155
XP_003317116 105 EVSRDITGPQAAPSAFPHQELPRALPAAAAtaGCAGLEATYSNVGLAALPGVSLAA---------------------SPV 163
XP_021582099  85 EVPRSSTRPQAAPSIFPPQQLPKASPVSPS--PFIGPEDTYSNIGLAAIPRASLAS---------------------SPV 141
XP_008535515  93 EESRGTIRP---PAAFSHRELPQA--------PSISPEATYSNVGLASIPRASLAA---------------------NPV 140 Przewalski's horse
XP_025326502  95 EVSRGTSRP---LVAFSPREPPFSPAAAS---PSIGPEATYSNVGLAAVPRASLAA---------------------SPA 147 dingo
XP_006104271  97 EVSRDTTRP---PAAFSHRDLPQTSPTTAAaqPSTGPEATYSNVGLAAIPRASLAA---------------------SPM 152 little brown bat
XP_023367802  96 EVSRDPRRLQAAPSAFPHQEQPQGPPAAT---PSAGSLATYSNLALVAIPRAGLAA---------------------SSV 151 small-eared galago
XP_017913004  78 EASRGMTRP---PAPFSHQELPLAA-------PSTGPEATYSNVGLATIPRARLAVssgvwagarltssyarpgpeaRPV 147 goat
EDL88722     156 vwpgrqlt-----isctrlgpGAEYACIQKHKGTEQGCQESQQ-KAKVTPATQMDVLYSRVCKPKRRDPRPDTDQLNLQD 229
XP_003317116 164 ---------------------VAEYARVQKRKGTHRSPQEPQQgKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKG 222
XP_021582099 142 vwagtrltigcarpglgarplVAEYSCIQKLKGTGQGPQELQQgTAERIPTAQVDILYSRVCKSESRDPGLIKNQPDFKG 221
XP_008535515 141 vwagarltsscarpgpevrpvVAEYGCIQKLQGTGPGPQALEQrKAQVIPAAEVDILYSKVNKPKRRSPGPVIDQPDPKG 220 Przewalski's horse
XP_025326502 148 vwagarltssraspgpeprpeVAEYACIRRLKGAAQGPQGLGQgTAAPTPAVEVDILYSKVRKPKKRDPGTAADQLDPKG 227 dingo
XP_006104271 153 vwagagltsscagdepearsvVAEYACIHKLKGTGRGPQGLDQgKVQGTPATQVDILYSRISKPKRRDAGSALGQPDPKS 232 little brown bat
XP_023367802 152 ---------------------ATEYSCVQKLKITQRAPQELQQaNAEVSPTAQVDILYSRVCKPKRRT------------ 198 small-eared galago
XP_017913004 148 ---------------------VAEYACVQKFRGTDQGPQGLGQgKVEATPPTQVDILYSRVNKPKRRDPGPATDQPDPKG 206 goat
EDL88722     230 GRTILALGNDVKYEAITLRGQDMKQGTLENVYESIKE 266
XP_003317116 223 QGAILALASDLAYQTLPLRALDVDSGPLENVYESIRE 259
XP_021582099 222 GGSILAPRNDMTCETLPLRDLSMDSRPLENVYESIQE 258
XP_008535515 221 RGAILVLGSDRAYEALPLRGRGVDNSLLENVYESIQE 257 Przewalski's horse
XP_025326502 228 SDAVLAVGSDQSHETLPLGGLGKDDGLLENVYESIQD 264 dingo
XP_006104271 233 RVAILTRGRNLDYEALPLRGLSTHSD-LENVYESIQE 268 little brown bat
XP_023367802     -------------------------------------     small-eared galago
XP_017913004 207 GGAILALGSDPAYEVLPLGGLAMDKSLLENVYESIQE 243 goat
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap