Conserved Protein Domain Family
DEPP
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pfam15343: DEPP 
Decidual protein induced by progesterone family
DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester. Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.
Links
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Statistics
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PSSM-Id: 464661
Aligned: 13 rows
Threshold Bit Score: 256.671
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012400432  31 DELQSDLLSSQSLDDYVKSICQLAQPTSVLDGDq-RLPYNRLRKPcrlrgktfndstsASHSEKSSPASPMQDITAHFSG 109
EGW13503      26 APGQEEPPNSPSLDDYVRSICQLAQPTSVLDKI--RSRPHRPYRP-------------AWTREKRCQAESVADSSPCFSS 90 
Q5BMD4        25 GAPGQEPPASPSLDDYVRCICQLAQPTSVLDKAtaWSPPNRSCRP-------------AWPREKRHQSESLEDSSPCFSS 91  Norway rat
XP_002722573  26 GGLGQEPPASPSLDDYVRSICQLAQPTCVLDKAtvQDGLSGPHRP-------------AWGLEETCPTATLQDSTARFGA 92 
Q5RBE4        25 GGPGQEPPPSPSLDDYVRSISRLAQPTSVLDKAtaQGQPRPPHRP-------------AQACRKGRPAVSLRDITARFSG 91  Sumatran orangutan
XP_006097602  25 GGPRQDPLASPSLDDYRRSICQLAQPTSALTEAaaRAQPSRRPWQ-------------ARAGEKSGSPGSLQDFTTPFSS 91 
XP_534951     25 GGPGQEPPASPSLDDYVKSICQLAQPTSVLDMAtaRAQPSRTLRP-------------AQAFKKNCPTESLQDITTHFSG 91 
AES10692      25 GGPGQEPPASPSLDDYVKSICQLAQPTSVLDVAtvRAQPGRTPRP-------------ARAFRKSPPTESLQDITTRFSG 91 
XP_003359328  25 VGPGEEPPASPSLDDYVRSICQLAQPTSVLDEAaaWARPRRPHRP-------------GRSCEKSRSDGSLQDITTHFSG 91 
Q1RMP5        25 GGAGEEPPASPSLDDYVRSICQLAQPTSVLDEAaaRVRTSRPHRI-------------ARSCAKSCPTGSLQDITTRFTG 91  cattle
XP_010587595  23 LSRGPEPPPSPSLDDYVRSICQLAQPASVLDEApaGDRPSRLHRP-------------ARACERSHPAMSLQDIPTCFSG 89 
XP_007478166  32 DELQSDLLSSQSLDDYVKSICQLAQPTSVLDGAq-RLPYTRPWRPcklrgktfndaslASHSEKSCPTSSLQDITARFSG 110
XP_005334468  25 GGTGQDPPASPSLDDYVRSICQLAQPTSLLDKVtaRSRPSRPHRS-------------PRSSEKSHPAASLQDNTASFGG 91  thirteen-lined ...

XP_012400432 110 QHSTLPLGNNIDPLDWLFGESQPKRQSWKDTLRRTGlSTDPSCLHKQNEPGksrvprR------IRACEAKLPGGPLTKL 183
EGW13503      91 LQPPLPSPGTDNPLDWLFGKSQEQQADRRDLPNGPD-SSDHWGVHRQMEEN------R------GRLCEARLPENSPGRK 157
Q5BMD4        92 LQPTLPAPGTDNPLDWLFGKSQEQQTDRRDLPNRTG-SSGHWGVHRQMGKD------S------GRPSEARVPEYSLGRK 158 Norway rat
XP_002722573  93 QQPPRPTAGPADPLDWLFGESQEKQSSRRQPARRTGaSAGLGGLHRQTDSGktravpR------GKLCEARAPGHSLART 166
Q5RBE4        92 QQPTLPMADTVDPLDWLFGESQEKQPSQRDLPRRTGpSAGLWGPHRQMDSSkpmgapR------GRLCEARMPGHSLARP 165 Sumatran orangutan
XP_006097602  92 QQPP----NTADPLNWLFGQSQEKQPRRRDLPRRTGpSADPWGPHREMESTkaggcpR------GKLYDARAPGHCPVGQ 161
XP_534951     92 QQPAPTRDCTADPLDWLFGDSQEKQPSRRDPPRTTGsSADPWGPHRQMDGGkaqgtsR------GRFCDASVQEHSLVRP 165
AES10692      92 QQPALPGDGTADPLDWLFGESQEKRSSRRDQPRRTGsSADSWGPHKQMDCGkargtpR------GRPWDARVQGHPLARP 165
XP_003359328  92 QQPVLPRAGPADPLDWLFGESQEKRPSRRDLPRRTGlPADPQALRKETNSGkaqggpK------GRLCEARAPEHSLERP 165
Q1RMP5        92 QQPSLPRTGTVDPLDWLFGESQEKQPSKRDVPRRTGpSADPWASRRQTDSGkapgtpR------GRLSDAKAPGHSLQRT 165 cattle
XP_010587595  90 QGPLLPRVGTADPLDWLFGESQEKQPTRKDLLRRTGlSANPWGLHRQTDTGkarsgpK------ARFCDARAPGHSLARL 163
XP_007478166 111 QNLTLPLGNNTDPLDWLFGESQTKRQSWKDALRRTGsATDPSPLHKQTETGksrvarR------VRACEAKVSGGPLGKL 184
XP_005334468  92 QQSTLPSAGTTDPLDWIFGESQRNETNRRDLLRRTGpSAGHWRAHREANSG------KpsgsprRRLFEARAFGHSLTRP 165 thirteen-lined ...

XP_012400432 184 SSEWGKVWEKRTQPSMLNASLKYSSSSHQDR--ISRVLNSNLPVIYEL 229
EGW13503     158 SGHRQQTSDRKSWTSRKSHQALAAVSGSRPSs-ILSTLCLHLPVIHEL 204
Q5BMD4       159 PGHRHQTSNLKSWTSRKPCQALASVSSSRPSs-ILGTLYLHLPVIHEL 205 Norway rat
XP_002722573 167 SRDGPQSANLRSHMAGRPSRATDSSYSPRPSs-ILRTFYLHLPVIHEL 213
Q5RBE4       166 PQDGQQSSDLRSWTFGQSAQAMASRHRPRPSs-VLRTLYSHLPVIHEL 212 Sumatran orangutan
XP_006097602 162 LRDWHQGS----RASRQPIRAAAPPPSSRPSs-VLRTLYLHLPVIHEL 204
XP_534951    166 SRDWHQCS----WASRQFSGAAASPPAPRPSs-TLRTLYVHLPVIHEL 208
AES10692     166 SRDWHQGS----WASRQLCTDVASPPAPRPRs-TLRTLYLHLPVIHEL 208
XP_003359328 166 LRNWHQCS----PASVQPGRDAASSTSPRRSs-ILRTLYLHLPVIHEL 208
Q1RMP5       166 SRDWHQCS----QASGQPGQDAGSPTSPRHSs-ILRTLSLHLPVIHEL 208 cattle
XP_010587595 164 PQGRHLSS---SWDSRQ----------PRSSgsVLRALHSDLPVIHEL 198
XP_007478166 185 STD--KALEKRTQPSALNAALEYSSNSHQGR--IPRSLNSNLPVIYEL 228
XP_005334468 166 SQDVHQSSNLNNWASGQPGRATASPCNPRPSs-ILRSLYLHLPVIHEL 212 thirteen-lined ground squirrel
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