Conserved Protein Domain Family
GEMIN8

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pfam15348: GEMIN8 
Gemini of Cajal bodies-associated protein 8
GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.
Statistics
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PSSM-Id: 464664
Aligned: 29 rows
Threshold Bit Score: 228.765
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017201747  13 SWYSHPVYSRYWQHYHQAMAWMRSHQNAYRKAVESYFSS---LCYFAPGLQPQSAYDGEAGYPQLSSDRPMVSEDFHCTy 89 
XP_005996189  14 PWYAHQMYSRYWRHYHQAMHWLHRHKEAYRKAVESFYYL---LWHSRMT-AEGHRYADWSDDERPVRRSHCPSELGRVNq 89 
XP_015217242  10 PWYSHPLYARYWSHYQQAAHWQHKHWQAYRKALEAAYCV---PYRAEGA-AVARRH----------------SSGSEREs 69 
XP_005463147  10 SWFSSPVYSRYWQHYQQAMAWHQRHRRAYRKALEAAYGP---CCYQEEGRSDRARYADWSSAE----------------- 69 
XP_007228750   9 AWYSHPVYARYWLHYQQAMTWHQRHRQAYSKAVQAAYGP---ALYHMFP-TTSPRYTDWHSEE----------------- 67 
XP_005168438  11 LWFAHDVYSRYWQHYQQAMNWNQKHKRAYRSALEAGYFQ---TLYSMNPSATMQCYSDWHGNE----------------- 70 
XP_416829     13 PWYSQKMYARYWKHYDLAMRWMHRHQEAYRKAMESFYHV---PWPPYAA-SPSRRYSDWDGDDPPCTHNRF------SNy 82 
XP_016154390   6 PWYSQKVYARYWRHYDLAMRWMRRHQKAYRKAVECCYHLprhPWHPAAA-SPSSHYPHWGGNDLSHSQNCSPSYRPSVRv 84 
XP_012812587  11 PWYAGRVYARYWKHYSQAMYWLYRHKRAYSVAMASLSYP---SWYPAGN-VQNRRYSDWEGGKSSQSDIYL---RPHRQv 83 
XP_003218936  84 PWHSQKIYARYWKHYNQAMEWMYRHRNAYNKAMEFLYNQ---SFCPPAD-HPSSRYADWDEGE-----------HLHEQa 148
XP_017201747  90 SPCERYGRLPHDSGRMQVSIRKdqTVSEEEEEEgeddeeeeLESESDGEVECDVSNMEITEELRQYFATTEKHREERRRQ 169
XP_005996189  90 RESQSQRWQYPTPSSKHQASEEkeSTSEDEEDD--------DDSGSGDEIECDVSNMEITEELRQYFAQTERHREELRRQ 161
XP_015217242  70 AGPEACPRFPSGGKRGPSASRRaaGTKRVRCSRdg-----eENSSSDGEVECDVSNMEITEELRQYFAETERHREERRKQ 144
XP_005463147  70 ---------------------------SNSEDEeg----gvEESSSESEIECDVSNMEISEELRQYFAQTERHKEELKKQ 118
XP_007228750  68 RKDRTRGRMKRRGRGYAVEEDEevPEST---EE--------SESSEESEIECNVSKMEISAELRQFFAQTEQHREELKKQ 136
XP_005168438  71 ----------CLKNSHRDRLKEkrENEITGSDSei-----eEESSDESQLECDVSNMDISEELRQYFAQTERHRQELKKQ 135
XP_416829     83 SPRGRAQQYMDAQPGKEDDDRE--EEEEDSEVE--------EDSESEGEFEYDLSNMEITEELRQFFAQTERHREELRRQ 152
XP_016154390  85 PYHGGAQQYAGAYQEREDADEDseMEEDAERDTem-----eEDSESEGEIEYDLSNMEITEELRQFFAETERHREELRRQ 159
XP_012812587  84 IHPQRTRPCLKVSESKEIESEMecDKEVTSDSE-------------EEGIECDTTNMEITEELRQYFAETERHREELRKQ 150
XP_003218936 149 FTQNRPTRYYPRSRQAPYNTKRrqTVEMVLETD--------SESESEGDVEYDLSNMEITEELRQYFEQTERHREELRKQ 220
XP_017201747 170 QQLDAARLEDYVNADHDLYYNTH-RSVEPPIERPGARRQAEMKLLYGESAAKIQAMEAAMQLSFDKHCNRKLPKYWPVIP 248
XP_005996189 162 QQLEAECQDSYVAADHDLHVSAG-RTVQPPTERPGERRVAEMKRLYGEDAAKIQGMETAMQLTFDRNCDKKQPKYWPIIP 240
XP_015217242 145 QQLEEEQQSAYVPADHDLYRVAR-RSAQPPRDQPGVRRGIEMKMLYGEDAAKIQGMETAMQLTFDRNCDLKQPKYWPVIP 223
XP_005463147 119 QQMEAEQQGSYVPADQDLHSFSLqSSVAPPLERPGERRTAEMKKLYGGDAAKIMAMEAAMQLNFERNCDLKQPKYWPVIP 198
XP_007228750 137 QQMEAERQEDYVLADQDLHRVSW-RSAQAPVERPGERRSAEMKKLYGKDAAKIQGMETAMQLTFDRNCDRKQPkywpvip 215
XP_005168438 136 QQMEAEQQDSYILADQDLHRVSW-RSTLPPSERPGERRTAEMKKLYGKDAAKIQGMETAMQLTFERNCDKKQPKYWPVIP 214
XP_416829    153 QQLEAEQQEMYVEADQDLYRNMK-RSVEPPAERPGERRVAEMEKLYGDEAAKILAMETAMQLIFDRNCDKKQPKYWPIIP 231
XP_016154390 160 QQLEAE--DPYVEADQDLHRRVE-RSVEPPTERPGERRMAEMKKLYGAEAAKIQAMEAAMQLIFDRNCDKKQPKYWPIIP 236
XP_012812587 151 QQLEAENHEQYIAADHDLHVATR-TSKEPPSERPGERRRAEMKKLYGEDAPKILGMETAMQLNFDRHCDKKQPKYWPIIP 229
XP_003218936 221 QQLEAEHHDMYVEADHDLHLSTG-RSTQPPAEKAGERRTAEMRKLYGVGANKIQAMETTMQLSFDRNCDKKQPKYWPIIP 299
XP_017201747 249 LKF 251
XP_005996189 241 LKL 243
XP_015217242 224 LKL 226
XP_005463147 199 LKL 201
XP_007228750 216 lnl 218
XP_005168438 215 LNL 217
XP_416829    232 LKL 234
XP_016154390 237 LKL 239
XP_012812587 230 LKL 232
XP_003218936 300 LKL 302
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