Conserved Protein Domain Family
TSKS
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pfam15358: TSKS 
Testis-specific serine kinase substrate
TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ. Recently it has been shown in human testis to be localized to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function. TSKS is localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis.
Links
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Statistics
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PSSM-Id: 434661
Aligned: 3 rows
Threshold Bit Score: 506.166
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002917876  66 PMHWCLnlkrssACTNVSLLNLAAMEPTDTSGTDSttedsgPL-------VLPVPPASPTPPWASDDPDITEILSGVNSG 138
XP_007492710 263 PTRWCL------PCPHPRPLKKTIRPPSEPDPQAD------PP-------TEPQPEPQPEPELEPEPAPVSSPTPMPHTG 323
XP_003222742  71 NSK--LnlkrssACTNVSLLNLTDGERDDSTTENEstddgsPPggaagerSAPLPPIKSVWSEYDDDDDTSSQQEVSNSG 148

XP_002917876 139 lvrakdsitslkekttrvnqhvqtlqsecsvlsenlerrrqEAEELEGycsqlkencrkvtrsvedaeiktnvlkqnsal 218
XP_007492710 324 -----------------------------------------SPTELSG-------------------------------- 330
XP_003222742 149 llrakdsitslkertskvnrhvqnlqsectvlcenlerrrqEAEDLEEyctqlkdccrkvtksvedaevktnvlkktsvi 228

XP_002917876 219 leekLRYLqrqlqdetprrqeael-----------qeleqkldaglsrhgLGPTAQSPGCCGPPGSP---NEPPRPRSMA 284
XP_007492710 331 ----PRLL------------------------------------------VNPGDGPEGQGQSEGLGl-aQVQSQSRTGE 363
XP_003222742 229 leekLRFLqrqvqvedlsrqgrewqeleqrmasgiskqlldlvsnataiaLRPSNSEEGELPPPTAAilaSINNLRVALE 308

XP_002917876 285 PGGWgmgprage--gpivseqEMQKVSAGLEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQA 362
XP_007492710 364 SGEL-----------------ELQKVTAGLEELRREVSSLTARWYQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQA 426
XP_003222742 309 NGHMraglgdevsidgksntaSTLACIPLLEEIRKCVLELSGQSQREALTQKEVLRLLAQLGVRLEGLIPQWERTQVEHS 388

XP_002917876 363 QAARGLQELRGRADELCTMVERSAVSVASLRSDLEGLGPVKPILEELGRQFQSSRRGSDLSMNLDRPpqG--SCGRCASQ 440
XP_007492710 427 QTARGLQELRGRADELCTMVERSAVSVASLRGELEGLGPVKPVLEELGRQLSSARRGSELSMSLDRP--G--SCTRCGSQ 502
XP_003222742 389 QA---LRMLREELDEVSATVKRTSVSLTQLRADLDGVRQVKPLLEEVSRHLSVLK-------PLETPerQtvSCARCSSY 458

XP_002917876 441 GPQLSTESLQQLLERALTPLVDEVKQRGLAPA-CPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLL 519
XP_007492710 503 GQQLSSETLQQLLERALTPLVDEVKQRGLAPA-CPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLL 581
XP_003222742 459 S-FVNTESLRQMVEQAVAPILEELKQRTPPPGtCPSCQLLQKKIMDLEQSALDIHARAEVLSSNVRLAHDEALRANYLEQ 537

XP_002917876 520 TDKMKPEEKVATVDYLHLKMCSLHDQLSNLPLEGSTGTMGGGSGGGAPPKRGGPTPEQ 577
XP_007492710 582 TDKMKPEEKVAALDYLHLKMCSLHDQLSSLPLEGSATGLGGGSSGGAPPKRGGPAPEQ 639
XP_003222742 538 ARIGTDKDKSSSLDYLQNKQSSLNSQLVLVSQEGMPQSPAVSLAANVALTKRSSCPGE 595
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