Conserved Protein Domain Family
PAXIP1_C

?
pfam15364: PAXIP1_C 
PAXIP1-associated-protein-1 C term PTIP binding protein
This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localize at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length.
Statistics
?
PSSM-Id: 464674
Aligned: 9 rows
Threshold Bit Score: 111.386
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001636891   7 YWVIENSDDERDEElkaf----kgnlTGDIPIQILKH---YKQIEQDGVIEIKLEEYRKQQkddlPVKQkrkEDEEDRNA 79 
XP_002124463  17 DWHVSGSDGEDASD------------YQPDPTTIVKL---YNLINSGELPPLQTFIHPRDK----LQTK---ELQVKQES 74 
NP_001313619  87 EWMIPYSDEEMEEPq----------nWMPPPAEIKRL---YELLAKGEELELQWVPLPRRP----PTPPrtpSPEGDGDD 149
XP_006011491  38 DWYVVCSDEEVENPe----------nWSPSPNEIKRL---YELIVEHGTLELQMELLPRRE----LTPEp--EPEEEQSE 98 
ELW66367     155 vWKVECSDEEVELPadg-------qsWMPPPSEILRL---YELLAAHGTLELQAEILPRRP----PTPEa--QSEEERSD 218
XP_008115335  60 DWCIPCSDEELDSPd----------nWMPPPSEIRHL---YELIAEQGTLELQAEILPRRN----PTPEp--DSEDEDKS 120
EEN43601       6 DFDIPASDDELAASeswdaehknyvsWEPPAADIASL---YEKLEKDGVIELQMKCLPRRA----PTPKp--EEPDTKEE 76 
CCD78717       5 NFRLLDDDTQFMDK-------------YPNGLSLVDLlpfYDSISKNEPLKLEWVCPGKID----PNVQretTKIRTETN 67 
XP_029953660  94 EWELAYSDEEMEDPk----------nWMPPPAEIKRL---YELLAKGEMLELNFVPLPRRP----PTPErtpSPERDDEE 156 jewelled blenny
XP_001636891  80 DGEIDEKKQNYANDRSVeASAFDYMDD---------------SDEWQEPKRTPKh---gRVNKKRVGSLQNVISDLKRFK 141
XP_002124463  75 PALLKSESIETKTSPSE-PNEFDFDSQst------------aSVKRFTPKRTPN-----RPQQKKVARMDKVCSNILKYK 136
NP_001313619 150 --TQDHTQEQAERKALT-PTEFDFDEEqtl---------atpKNSFLTRRRTPGss--aRSTVKREARLDKVLSDMKRHR 215
XP_006011491  99 --EEPQEEQEEEKLPE--PTEFDFDDElv-----------tpNPSFMNRRRTPGs---lVKSQKRKARLDKVLSDMERHK 160
ELW66367     219 --EEPEAKEEEEEKPHM-PTEFDFDDEpm-----------tpKDSLIDRRRTPGs---sARSQKREARLDKVLSDMKRHK 281
XP_008115335 121 EGQTEDQEEEEEEKPHV-PTEFDFDDEps-----------spKSSLIDRRRTPGs---lAKSQKREARMDKVLSDMKRHK 185
EEN43601      77 EKEEEKPEETPSKKPAV-PS-FDFDEFsme---------ttpAKTFTPTRRTPGsrptpRSGQRRVARMDNIMSSIMRHR 145
CCD78717      68 DNPVPKVSESLTSIVKL--KEFDFDESpnqpsipsvplgaaaQNANLPLRRLAGts-rhPPRQPRVASMDKILNDFFKTR 144
XP_029953660 157 DETKERERQDRERKPPT-PTEFDFDEEqtq---------atpKNAFINRRRTPGss--aRSSVKREARLDKVLSDMKRHR 224 jewelled blenny
XP_001636891 142 ELDQSV 147
XP_002124463 137 KLDEEQ 142
NP_001313619 216 KIEEQI 221
XP_006011491 161 RLEEQI 166
ELW66367     282 KLEEQI 287
XP_008115335 186 VLEEQI 191
EEN43601     146 RQDpdd 151
CCD78717     145 KEPSSP 150
XP_029953660 225 KIEEHI 230 jewelled blenny
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap