Conserved Protein Domain Family
BioT2

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pfam15368: BioT2 
Spermatogenesis family BioT2
BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis.
Statistics
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PSSM-Id: 464678
Aligned: 7 rows
Threshold Bit Score: 230.512
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023367243    1 MNSAKYLLTT-SKKLASVPELRSSRSVsVKLpsPPYSKRRNSAKVVHDRIEPMVLRSPPTGGSVVQYALPIPSSRIKDIL 79  
NP_083337       1 MKCAKHPSTI-SMKLTSVPELPYKKGL-LNS--SPKPKEKHNAKSKYGKNESMVLRSPPTGESIVRFALPIPLSKTKDKI 76  
XP_007666002    1 MKPTKQMKCIcGETSENA---SKKHSVvLQEspSISTNKKLS---IPEEIEPMIIASPPTGECLIRYAIPIPSDNSQ-MT 73  
ABR88144        1 MKPVKHLLTT-SNKSANVPALTTKKGL-HNLplSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLL 78  
XP_019656536    1 MKPAKHLLAS-SNKLANVPEFTYKKGL-FNLslSPKPKEKRSAKLVRDKLEPMVLGSPPVGESIIRYALPIPSSKTKELI 78  
XP_017206204    1 MKPSKYLQST-SAALANVPELMYKKGL-LKAplSHKLKEKRSGKLVHDKMEPMVLRSPPTGESLLRYALPIQTSKTQELT 78   rabbit
XP_017443479    1 MKRANHLSTT-SKKSTGVPELPHKKGK-LNS--SHKTKEKHNAKPTYEKIEPMVLRSPPTGESIVRYALPIPSTMTKDLV 76   Norway rat
XP_023367243   80 AEDEMLVKITRHLKSIVATLEDAYGADIQSIPKAFVRSDQEDl---------cLSVGDDLSSFLTSCSHLAEQLEAAVKE 150 
NP_083337      77 SADEMVRRITTNLKMVVSNLEDTYGACYDNGEKAAEKSEAEG-----------LSIGDDVSSFLLCCSQFTSQLEEAVKE 145 
XP_007666002   74 HDLQMLRQTIDHLSQTVSVMQDVYAITREDEVIEFQDTEDGEr----------AFPGDDMTSFFFNCSSIATQLQKAVQE 143 
ABR88144       79 PEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEEl---------sLSVGDDMNSFLTYCSQFAAQLEEALKE 149 
XP_019656536   79 AEDELIRKITKHLKMIVSTLEETYGFTIQNGEKSVLKPENEEl---------tLSVGDDLNSFLVCCSQFAAQLEEAAKE 149 
XP_017206204   79 GKDQKIKMITKRLEMLVSTLEETFRLDIQGGEKQNVEPEQEE-------------VGEDIKSFLMRCSHLAAQLEAAVKQ 145  rabbit
XP_017443479   77 SDAEMVRRIAKNLKMVVSSLENTYGVHSDDGEKEEEKPEEEEeeeeeeeeeeyVSVGDDMNSFLLCCSQFAAQLEEAVKE 156  Norway rat
XP_023367243  151 EDTILESLFKWFQWQVNQMEE 171 
NP_083337     146 ECGALESLYKWFQQQVNQMEE 166 
XP_007666002  144 EKILLESLNQWFQQEVTLV-E 163 
ABR88144      150 EQNILESLFKWFQWQVNQMEE 170 
XP_019656536  150 ERNILESLFKWFQLQVNQMEE 170 
XP_017206204  146 EHNILESLSKWFHGQVSQVDE 166  rabbit
XP_017443479  157 ERNILESLYKWFQQQVNQMEE 177  Norway rat
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