Conserved Protein Domain Family
Joubert

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pfam15392: Joubert 
Joubert syndrome-associated
This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.
Statistics
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PSSM-Id: 464699
Aligned: 12 rows
Threshold Bit Score: 318.34
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021582246 2947 PLQMAGLTDIADIINDLITRGGVSSKELGLTEQQARSISRI---QHSS-GRCPQRTEKERREIRAWMKRKRKERMAEYLN 3022
EGV97562      205 QLQVTGLTDIADIIDDLITKSGVSSEELGLTKKQARNISRI---QQSS-GRCPQRTEEERREIKIWMKRKRKERMAEYLN 280 
Q8CE72       2894 QLQVTGLTDIADIIGDLITKSGVSSHELGLTECQARSISRI---QRPP-DRGPRRTAEERREIKAWMRRKQKERMSEYLG 2969 house mouse
ELW53479     2545 SLRSDQNTAFPDIIDDLITKGGVSSEELGLTEQQARRISRV---QHSY-SRRPQRTEKEKREIRVWMKKKRKERMAEYLN 2620
XP_031820080 2871 DFQITGLTDVADIIGDLITESGVSREELGLTEHQAMKISRI---HSTPkKRKSQRTEKEKREIRAWMKRKRKERMAEYLA 2947
XP_023481497 2898 PFQMTGLTDIADIIDDLITKDGVSSDELGLTEQQTRNISRI---QHSS-GRRPQRTEKERREIQAWMKRKRKERMAEYLN 2973
XP_024837266 2877 PLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRM---QHPS-GRRPQRTEKERREIQVWMKRKRKERMAEYLN 2952
XP_023610782 2784 PLQMTGLTDIADIIDDLITKDGVSSKELGLTEQQARSISRI---QQSS-GSRPGRTAKERREIQVWMRRKRRERMAEYLH 2859
4_pfamImport    1 PLQMTALTDIVDIIDDLITKDGVSSEELGLTE-QAKTISRI---QHTS-GRHPQ-------EICIWMKKK-KERMAEYLH 67  
XP_005672479 2894 PLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRI---QPSS-GRRPQRTEEERREIQVWMKRKQKERMAEYLN 2969 pig
XP_015195761 2577 TLGLSGLSDIADILGELVRGGGVSASALGLSETQAIRLSRAgaqQRWQpGRKVRRSERERREVREWMRRKQRERLSEFHR 2656 spotted gar
XP_016160307 2863 PLQITGPSDVTDIVNDRVVESSTSLLELDLARTKTKDISRV---LDSA-SGHSQRTEKERKEIQTWMKRKQKERMREYLK 2938 Collared flyc...
XP_021582246 3023 QLAEKRGQEHDPFC-ARSNPFYMTSKEIRLRQKMKHEKDRVLLSDHYSRRITQAYSLMNELLSESVQLPVTAQ---KPSP 3098
EGV97562      281 QLAEKRGQERDPFC-PRNSPFYMTSRQIRQRQKMKHEKDRLLLSNHYSQRISEAYHLMNELLSDSVQLTAPAD---QPLP 356 
Q8CE72       2970 QLAERRGRERNPFC-PTSSPFYMTSRQIRQRQKMKREKDRLQLSKHYSQRLSQAYSLMNELLSDSAHITAPAE---NPLP 3045 house mouse
ELW53479     2621 QLAEKRGQERDPFC-HRSNPFYMTSREIRLSQKMKHEKDRLLLSDHYSRRISQAYSLMNELLSESVQLPATAQ---KPLP 2696
XP_031820080 2948 QLAQKREQEYEPFQ-PQRHPLCMTSKEIRLCQRMKNEKDRLQLSEHYDRRVAQAYSLMNELLFESAQVPRRCL---KKPP 3023
XP_023481497 2974 QLAEKRSQEHDPFR-PRSNPFYMTSREIRLTQKMKHEKDRLLLSDHYSRRISQAYSLMSELLSESAQLPAAAQ---KPLP 3049
XP_024837266 2953 QLAEKRGQEHDPFC-PRNNPFYMTSREIRLRQKMKHEKDRLLLSDHYSRRISQAYTLMNELLSESVQLPAAAQ---KPLP 3028
XP_023610782 2860 ELAERRGQEHDPFC-PRSNAFYMTSREIRLSQKMKHEKDRLLLCDHYSRRISQAYSLMNELLSESVQVPA--Q---KPLP 2933
4_pfamImport   68 QLAEKRGQEQASFC-PRNNPFYTISREIGPRQKVKYEKDRLLLSDHYSRQISQAYSL----------LPTTAQtqmQQLP 136 
XP_005672479 2970 QLAEKRGQEHEPFC-PRSRPFYMTSREIRRRQKMKHEKDRLLLSDHYSRRISQAYSLMNELLAESVQLPATVQ---KPLP 3045 pig
XP_015195761 2657 QREERRQREHRPFA-ADSVARSPTSKDISISQKIKEEKDKAALLEHHSRRTREALRLMDEMLTDTVPLPTAHP---PSLA 2732 spotted gar
XP_016160307 2939 KLDEQRQKEHHPFNlGKNTHHHPTSKDIRIFQKKKEEKDKALLSEHHRIRISQALSLMNEMLSETVPSPASDH---RALS 3015 Collared flyc...
XP_021582246 3099 NKP---ST-------AWHSGQQCCPSPRREYHHgHNFLINQPGKVKC-IS-KS--SHTHKGKTLEPSQ-------DShwr 3157
EGV97562      357 NRP---PT-------AQHYRQQHCSSPRRENPHgQNFLINRPGRGRH-IS-RS--SRLQKGKPLEQSK-------GS--- 412 
Q8CE72       3046 PGP---------------YRRQRGSSPKRENAHgQSLPVNRPGGDRH-IS-RS--SHLCKGQPRGSSQ------------ 3094 house mouse
ELW53479     2697 NKR---ST-------AQSSRWQH-------------YPRGKLKQFVF-IG-TA--TFTIQKKGggvkaavr--------- 2740
XP_031820080 3024 GSPa--KS-------ARISRKQYHLPPKGEDRNiNTLSPNRNSKVRF-AS-KP--TYIHGRTPLSQHQ-------HPsqr 3083
XP_023481497 3050 DRP---RT-------AHTSRRQRSLSPRGENRHgHNFPINQPGKVRN-IS-KP--SCTPKGKPLGQPH-------GSpwp 3108
XP_024837266 3029 N-----RK-------AHIPRRQLSPSPRGENRHgHNFPIYRPGKVRH-TStKP--SYTQKGRPFGQSQ-------GSpwp 3086
XP_023610782 2934 SKP---RT-------VHTCRLQSSLSPRRETRYgHNFPVNRPGKVRN-IP-KP--SYIPKGKSFGQPQ-------GSpwp 2992
4_pfamImport  137 NKR---RT-------AQVSKQQRFPCPNRENQHgNNFPINRRGKVSC-IP-KS--SYTQKGKPFVQPQ-------DSp-- 193 
XP_005672479 3046 NKP---RT-------TQIPRRQRSLSPRRENQHgHNFPIHRPGKTRY-ISsKP--SYTPKGRPFGHPQ-------GSpwp 3105 pig
XP_015195761 2733 HTPgrsSRrgrapirSQSAGR----TGRRPSQAgQARSLSSPGRTQL-FT-GSrvTAPQSETPAWRGR------------ 2794 spotted gar
XP_016160307 3016 STRs---P-------QAYRRSNVASSP--------------GGHLDSpVLaER--SRIAAKPGFGQKVqrftpdlGLtqs 3069 Collared flyc...
XP_021582246 3158 cgaanfpiekraggakealrkavqspvTFPT-------------GSHAPC--LQ---------HTKKHrsaGLAPQTTQV 3213
EGV97562      413 ---------------------------SRRQ-------------GSNTSCqsLL---------HTNSR---GVAPPKKQV 440 
Q8CE72       3095 -----------------------------LR-------------GSQPPCqsQK---------PLRSRgaaGVGPPVQQA 3123 house mouse
ELW53479     2741 --------------------kavkspvTFQK-------------DSNAPYhsLQ---------QIKNHksaGLAPQTKQV 2778
XP_031820080 3084 nrkaat-------------svkkttevTRKP-------------ARNVSCfsDLssqdfsyppRRTSYvksSETSTSTTN 3137
XP_023481497 3109 rgtatftiqkksggakmavrkavqspvTFQK-------------GSRAPCcsLQ---------HTKSRa--GLAPQTKQV 3164
XP_024837266 3087 retatfttqrkagaakmvvrkvvqspvIIRK-------------GPNAPC--QH---------CIKSHrsaGLAPQTKEV 3142
XP_023610782 2993 hgtitftqkkag-gargarrkavhspvTFRK-------------GSTAPC--LQ---------HSKQHgsaGLGPHTEQV 3047
4_pfamImport  194 ---------------------------CLQK-------------GSDAPYcsLQ---------HTKNYg--------tKR 216 
XP_005672479 3106 hgtatftiqkkadgasvvvrkam----------------------pspvtiqkgphapwhglqctknhrgaGLAPHTKQV 3163 pig
XP_015195761 2795 -----------------------------ASkagrasrlglhrpASALPRdrMS---------QLTRRgmvSDPDPDAWR 2836 spotted gar
XP_016160307 3070 rgntcmilqks--tsrrqlrnatncpvDSRH---------------SAECr-VS---------RRSTQkppQVTTAVQTE 3122 Collared flyc...
XP_021582246 3214 RIEYEREETMTSPWT-------------------------------LPPEIHR--ILHE--TPGSLLQDLSQEEPE---- 3254
EGV97562      441 CIEYEREDTVVSPWT-------------------------------LPSEIHR--ILHD--RPKTLLQDISPAEEEep-- 483 
Q8CE72       3124 CREDEREEMVVSPWT-------------------------------LPSEIHR--ILHG--RPESLLQDMSPADEEep-- 3166 house mouse
ELW53479     2779 CIEYEREETVVSPWT-------------------------------LPSEIHK--ILHE--SPSSLLQDLSPAEEEqp-- 2821
XP_031820080 3138 AEEYEREHDKMSSWT-------------------------------MADHADR--ILCR--GPWSSLEDFSPAEDEk--- 3179
XP_023481497 3165 CIEYEREETVVSPWI-------------------------------LPADIRQ--VLRE--SHSSLLQDLSPTKEEp--- 3206
XP_024837266 3143 CIEYEREETVVSPWL-------------------------------VPSDIRA--ILHE--SHSSLLQDSSPTEEKs--- 3184
XP_023610782 3048 CAEDEREETVVSPWL-------------------------------VPSDIRR--ILHG--SHSSLPQDLSPTEEEp--- 3089
4_pfamImport  217 CVEYEREETVLSPWT-------------------------------LPSEIHK--ILHD--SHDSLLQSLSPPEEEk--- 258 
XP_005672479 3164 CLEPEREEMVVSPWL-------------------------------VPPDIRA--LLRR--SQSSLLQ------------ 3196 pig
XP_015195761 2837 SRRGDRERAAPVHSRgrrgeagrpsvsprgsgleapevwgavvspsTPAKFHTlrGVENelFLQGLSGNRSPLRRA---- 2912 spotted gar
XP_016160307 3123 GVDLDTDRDVVSPWT-------------------------------VPDDIQR--ILQE--THDSMF------QASaahs 3161 Collared flyc...
XP_021582246 3255 ---PHFGVAGMHSMSESTGSILSNLDWNAIEDMVASVEEKNLS 3294
EGV97562      484 --eSSVLVAGMDSVSESTGSILSKLDWRAIEDMVADVEDKNLP 524 
Q8CE72       3167 --ePPLLAGGMDSVSESTGSILSKLDWKAVEDMVASVEDKNLS 3207 house mouse
ELW53479     2822 --rTPFGMGGMDSMSESTGSILSKLDWNAIEDMVASVEDKSLS 2862
XP_031820080 3180 ---FSVSINGLTSGSESTSSILSKIDWRAVDNMVAMVKN---T 3216
XP_023481497 3207 --kPPFEVSGMDSMSESTGSILSKLDWNAIEDMVASVEDKSPS 3247
XP_024837266 3185 --eAPLGVGGTESLSESTGSILSKLDWDAVEDMVAGVEDKSLS 3225
XP_023610782 3090 --aSPTGEGGMDSVSESTGSILSKLDWNAIEDMVANVEDKSLS 3130
4_pfamImport  259 ---PSAGVSGMDSRSEGIGSILSKLDWNAIEDMVARVDDKHLS 298 
XP_005672479 3197 -----DSVGGPDSLSASTGSILSKLDWDAIEDMVADVEDKSHL 3234 pig
XP_015195761 2913 ---DLDGLNELDALSDSTGSILSKLDWAAIENMVASEGDVEIA 2952 spotted gar
XP_016160307 3162 lsfSPLGSTNTDSVSESTGSILSKLDWNAVEAMIADVEDK--- 3201 Collared flycatcher
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