Conserved Protein Domain Family
NYAP_C

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pfam15452: NYAP_C 
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 464724
Aligned: 7 rows
Threshold Bit Score: 284.55
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_024837474  398 RSSPSV--PHSTPR-PVSD-GSKMVNAAVNTygsaPSGSrsrtptSPLEELTSLf----TSGRSLLRK-SSSGRRSKEPA 468 
XP_001373995  469 RSSPSV--PHSTARnTLQE-GGKMVNASVNTygssQSGSrsrtptSPLEELTSLf----TSGRSLLRK-SSSGRRSKEPA 540 
XP_007245255  691 PQLPILqhSEG---------GAKGGTSTTQAhqqaKAGF------LPWDSSSSLgi-deQAYWPMHRK-LSFSHSSRDTE 753 
EHB13478      944 NKGCGVgaPSPMVKiQLQEqGTDGGAFASIScahvIASAg-----TPEEEEEEMgattfGAGWALQRKvLYGGRKAKELD 1018
XP_014353933  557 KSCSAV--PEPTVKtQVQDrGA----FASIScsraITNSdsrgvsSPSEEGLy------GLGWALQRK-LSCSRKPKDSD 623  coelacanth
XP_015217256  461 RSSSSV--PHSLIKnTSQE-GAKLANSSSSThgsmQNVSrsrtptSPLDELTSLf----TSGRSLLRK-SSSGRKSKEPA 532  spotted gar
TKS83903      654 SQTPSLqqPSSLTGvGEGAcKSNGGSASLQS----KVGF------MPWDSSASLaa-deGSYWPMQRK-LSFSHGSRETE 721  big head croaker
XP_024837474  469 E-----------------KsTEELKVRSHSTEPIPKLDSKERghhG----ASSSREPIKAQEWDG-----------TPGP 516 
XP_001373995  541 E-----------------KpTDELKIRSHSTEPLPKLENKERghhG----ASSSREPIKAQEWDG-----------TPGP 588 
XP_007245255  754 K-----------------E---DARVWNGSTDALLRRDRDDVgvrG----GGHSGIPVRASGRIGhses----lagADGP 805 
EHB13478     1019 K-----------------V-EDGARAWNGSSEGPGKMEREDR---G----PVASAIPVRSQGAEGllari---------- 1063
XP_014353933  624 SeyknsqtaarytifflsP-TEGSQGWSDQPEGRSSTEREEKaapG----ALASGIPIRTQGPEG--------------- 683  coelacanth
XP_015217256  533 E--------------------SEAKSRSHSTEPLPRHESKERgghQ----PPPKEQP-KAHEWDG-----------VSGQ 576  spotted gar
TKS83903      722 --------------------KDEGRAWNGSADALLRMDKEDL---GmgsrGGHSGIPVHFGGATSralghseslagVDSS 778  big head croaker
XP_024837474  517 PVV--TSRLGRCSVSPTLLAGnHSS------------------EPKVSCKLGRSAST-SGV--------PPPSVT-PLRQ 566 
XP_001373995  589 PVA--SSRLGRSSVSPTLLAGnSSS------------------EPKVSCRLGRSAST-SGV--------PPPSVT-PLRQ 638 
XP_007245255  806 PGFraLPRAGLPLPCQTFPAC-RNG---------------------ELGRLGRSSST-SGVrqag-gdvQRQSSL-PARE 860 
EHB13478     1064 hhdrgGSRTALPIPCQTFPAChRNG------------------DFTGGYRLGRSAST-SGVrqaa-lhtPRPCSQ-P-RD 1121
XP_014353933  684 GSSkgPGRTGLPVACQTFPAChRNGgnrycrvcwfqtrvpessSRPSFRPEFQTRVReSSSrpkfqnrvLDQ-SLaPPAS 762  coelacanth
XP_015217256  577 SAAaqSNRLGRTSVSPTLMLGsGVS------------------ESKAVCKLGRSAST-SGV--------PPASVN-PLRQ 628  spotted gar
TKS83903      779 PGFraLPRVGLPLPCQTFPAC-RNG---------------------EVGRLGRSSSA-AGVrqvgggdvQRQSSL-PARE 834  big head croaker
XP_024837474  567 AsdLHQS------------------------------------------------QVACMQW---------FHGDHTMLE 589 
XP_001373995  639 AsdLQQS------------------------------------------------QVACMQW---------LHGDHTMLE 661 
XP_007245255  861 A--LSQLqalsqapcspsltrpqmqaqqqaqfqlqqlhqhhlqlqfqqlaqlaaqAQPPASGggspgsggpVQRDGKLLE 938 
EHB13478     1122 A--LSQThpal----------------------------------------plplPLPPPPA---------RERDGKLLE 1150
XP_014353933  763 A----QT---------------------------------------------------PQSS---------KERDGKLLE 778  coelacanth
XP_015217256  629 GgeVQQS------------------------------------------------QVTQMQW---------VYGDNTMMD 651  spotted gar
TKS83903      835 A--LN--------------------------------------------------------Q---------TQRDGKLLE 847  big head croaker
XP_024837474  590 MIEKKRCLCKEIKARQKTEKGLCKQDSMPILPSWKKNAGAKKYSPPPYSKQQTVFWDTAI 649 
XP_001373995  662 MIEKKRCLCKEIKARQKTEKGLCKQDSMPILPSWKKNTGTKKYSPPPYSKQQTVFWDTAI 721 
XP_007245255  939 VIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRKTPEPRKTGTPPCQRPQAVVWDTAI 998 
EHB13478     1151 VIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQHTVLWDTAI 1210
XP_014353933  779 VIERKRFVCKEIKARRRPERGLCKQDSLPILPSWRKSTDTRKSGTPPCRRQQTVLWDTAI 838  coelacanth
XP_015217256  652 MIEKKRCLCKEIKARQKTDKGLCKQDSMPILPSWRKNNGTKKDSPPPYSTQTTVFWDTAI 711  spotted gar
TKS83903      848 VIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRRTPEPRKTGTPPCQRPQAVVWDTAI 907  big head croaker
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