Conserved Protein Domain Family
PCNP

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pfam15473: PCNP 
PEST, proteolytic signal-containing nuclear protein family
PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.
Statistics
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PSSM-Id: 464736
Aligned: 10 rows
Threshold Bit Score: 163.485
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17H13        45 IEEDRRRKEQLQKHNPLRPLPGGRKDSGSSSDDSGDDDNGSQSKT---APPKPSVMPKIGFSFQKPAANAKtsstlstsf 121 yellow fever mo...
XP_001847943  43 LDEERQRKEAQLRKAAESQRKYDHRRSSSSSGSSSSDGSDNEGPV---APPAPPVISKVGFSFQKPPSAKPtstgf---- 115
OWR45283      35 SPRRRRVSPSGHRGSPSRPG-RSRERNLENADKRRYSESWEESDEevpAPPPPPRISKISIDFSKPK------------- 100
XP_001122504   6 PGDEYRKGSSVYRAEDSRGDDRGRDRSPLRSDDRCEEANYNQSDA---------KKQKLAFGFGKKSGTEQk-------- 68 
XP_001363703  22 GPEEEAEKPVKTKTVSS----SNGGENSSRSAEKRSAEEEAEDFS---SKPVPAKIAKFGFAIGSQTAKKA--------- 85 
XP_006743063  26 GEARE--------TAASWSRRSNGGESSSRSAEKRSAEEEAAD-----LPTKPTKISKFGFAIGSQTTKKA--------- 83 
NP_001313647  16 GPEEKGSS-VKTKTVSS-------SKASGDSLRKRPAREIDPEDEs-kSTSAPPKMFKSGFSM---TAKKP--------- 74 
XP_004067142  16 GPQEEGDR-VKTKPVSC-STVGGDGAAYKRTSQHLSAEEEDESSE---DPPAPRKVSKLGFSMSSQAATKS--------- 81 
CAF99796      16 GPQEEEGR-VKTKPISC-STVGGKGTAFKRTSQHLAPEDDDEDEAs-qIPPAHCKISKIGLKMSSQMGKKS--------- 83  spotted green p...
XP_006639248  16 GPEEKGGKGVKTKTVSS----SNGGGSNTRSADKRSAEEAAGDSM---VQPAPPKVSKIGLS--SQALKKP--------- 77  spotted gar
Q17H13       122 nlqkaKPMAIQMKLG--TAPKKETPKL--LKPVANAfAGSDSDEEPEEMPAECRMRMRNIGRDTPTSSGPNSFGKTKHGF 197 yellow fever mo...
XP_001847943 116 -qlqqKPSAVQLKLA--SGPKKEQPKL--LKPTANA-FADDSDDEPEEMPAECRMRMRNIGRETPTSSGPNSFGKTKHGF 189
OWR45283     101 -----APIKMTLGAT--SKPA--------PKPTVASvFNADDDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGF 165
XP_001122504  69 -----KGIQIKLGST--SKPTVKATPI--QRPTVASvFNADEEDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGF 139
XP_001363703  86 -----PVISIKLGAS---KPKETVPTLapKTLSVAAvFNEDDDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGF 157
XP_006743063  84 -----SAISIKLGSS---KPKETVATLapKTLSVAAaFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGF 155
NP_001313647  75 -----MAISIKLGAN---KPKEPPPAIppKKSGLASvFNEDDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGF 146
XP_004067142  82 -----NAISIKLGAT---KPKEPVPSLppKKPALASvFNDSDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGF 153
CAF99796      84 -----NPISIKLGATvsVKPKEPVPSVppKKPGLASvFNEDDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKHGF 158 spotted green p...
XP_006639248  78 -----APISIKLGAS---KPKESAPVLpaKKPALAAvFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGF 149 spotted gar
Q17H13       198 CDSKKIFEKKLNTMTD 213 yellow fever mosquito
XP_001847943 190 CDSKKMLEKKLNSLHD 205
OWR45283     166 CDAKKVFEKNLKQALE 181
XP_001122504 140 CDSKKIFEKTLKKAME 155
XP_001363703 158 SDNQKLWERNIKSHLG 173
XP_006743063 156 SDNQKLWERNIKSHLG 171
NP_001313647 147 SDHQKLWERKLKSHTD 162
XP_004067142 154 SDHQKLWERKIKAQGD 169
CAF99796     159 SDNQRLWERKIKTQ-- 172 spotted green pufferfish
XP_006639248 150 SDHQKLWERKLKTHTD 165 spotted gar
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