Conserved Protein Domain Family
LKAAEAR

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pfam15478: LKAAEAR 
Family of unknown function with LKAAEAR motif
This family of proteins is found in eukaryotes. Proteins in this family are typically between 119 and 235 amino acids in length. There is a conserved LKAAEAR sequence motif.
Statistics
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PSSM-Id: 434744
Aligned: 12 rows
Threshold Bit Score: 182.988
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015220501  12 AHNWKNVPGSELKKMSLLQKARYLAYeepsKEVVNsvLISKQRLRGRAPVSRNPQKNPDPEAEEQ-----QRKQDTVIGQ 86 
XP_008529485  26 PKPGWALTLEGLAALRPEQRHHQLLF----GDLLE--DVGAAASIFPRESVELANRMPDPRAWTQsvelpAERQDRLLGV 99 
XP_011720747  40 PKPGWALTPQGLAAMLPAQRHRHLLF----GDLLD--DVGAAASTFPCGSVEPGYRMPDPRTWTQslelpAERQNRLLGV 113
NP_001100021  47 PKPGWALTQEKLAAMSSTVRRRHLLF----SDLLDmvEVG---SMFPRESVELSYCMPDPRIWTQalelpSERQNRLLGI 119
Q8BIG2        44 PKTGWALTKQRLVALSPTLRQRHLLF----GDFLD--DIGKVASMFPRESVELPYDMPDPRTWSQalnlpSEHQNRFLGL 117 house mouse
XP_014353620  15 PKNWKTFTAAELKKLNPQQRAKYVAYeepnKEVAAtmLTCLKRLKDQEYESKKYRQAIDEEALLQ-----RKDQEKLIGQ 89 
XP_011404671  79 LKNWKQMTPAELSKLTPMQKSRYMMYeptsKEILEkqMESLKRVRARKLLAKVDDPAPLLKSLIE-----HEENSELIGQ 153
XP_001634879  27 ARNRTQLNKKEIQKLPPQQRSRYLAYespaKEVAEsmAAARKRLKELKNQIKKETKPPALETVTE-----QDKHVKLIGQ 101
XP_002602336  30 AKNWRQLSPRTLNKMAPQEKSKYLAYeeapKPVQEaqASTLKRVRDLRKAHRRANPPMSMDEFVE-----KEKHSKLIGQ 104
XP_002121050   9 PKNWTKKSPQQLKKMGAQQRSRYLAYeeppKEIQDtvDLTQKRVKDLIQKQKNSTPRMNNEMEID-----RQKHSNLIGQ 83 
1_pfamImport   1 PKTWKKKSPHEIKKMGPQERSRYMAYeepsKDIQDqlDNAHKRVKNAIQTERSLKPRLNIEDELE-----RHKHSNLIGQ 75 
EGW10556      33 PKAGWALTQERLAAMIPTQRRRYLLF----GDMLD--DTGASTSIFPRESVEVSYCMPDPRTWTQalepaAVRQNRLLGV 106
XP_015220501  87 LRAAEARNRVRSMRVRYQSMRAQEINHLISCQPTAQKAVRLELLLPAKLEKISPGnDAVDKLE 149
XP_008529485 100 LKAAEARGRIRALRLRYTRMRAEEISLLILQQKSARAAIRLELFLPPQLKPTRIR-DPLDRQE 161
XP_011720747 114 LKAAEARGRVRALRLRYTRMRAEEIALLIQRQKSARAAIRLELFLPPQLKPTRIP-DPLDRQE 175
NP_001100021 120 LKAAEARGRIRALRLRYTRMRAEEISLLIQKQRCARAAIRLELFLPPQLKPTKIP-DPLDRQE 181
Q8BIG2       118 IKAAEARGRVHTLRLRYTRMRAEEISLLIQKQSSARAAIRLELFLPPQLKPTKIP-DPLDRHE 179 house mouse
XP_014353620  90 LKAAEARNRLRLMRMRFQALRAQEINHLIACQPTARKAVRLEAFLPPQLDMQNPG-DTIDKLE 151
XP_011404671 154 LKAAEARYRVRNTQLTYDMERSQELQHLIASQQTAQEAVRLQTFIPPTPLYVEVP-DYLNKTQ 215
XP_001634879 102 LKAAEARNRIRLMRLRYEHNRASEVNHLISCQPTALKAVRLQSLVPPETDPIKIR-DLLGKGE 163
XP_002602336 105 LKAAEARNRLRVMRLRYQSNRAQEVKHLIACQPHSLKALRLEALVPPYLDNSSPG-DKLDRMQ 166
XP_002121050  84 LKAAEARNRIRVMRLQYQAMRAHEVKHLISCQPTSLKALRFEALVPPYTNNRNPG-DHLDKLD 145
1_pfamImport  76 LKAAEARNRIRVMRLQYQAMRAHEVKHLIACQPTSLKALRLEALVPPYIDNNNPG-DQLDKLD 137
EGW10556     107 LKAAEARGRIRAMRLRYTRMRAEEITLLIRSQGSARAAIRLELFLPPQLKPTKIP-DPLDRQE 168
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