Conserved Protein Domain Family
PGC7_Stella

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pfam15549: PGC7_Stella 
PGC7/Stella/Dppa3 domain
The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.
Statistics
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PSSM-Id: 464759
Aligned: 10 rows
Threshold Bit Score: 128.88
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004064247   1 MD-PLQKWNPASPSKS-----SLMTAAETSQEGPAPSQPSYSEQPMMGLSNLS--PGPGPSQAVPLPEGLLRQ------- 65 
XP_008246735   1 MD-PLQNWSPGFAADA-----SPMAMAETSADSRAASQPPSAEQLVWGLGNMN--PGAGPDLPVPPPAGLPQQ------- 65 
ELK03273       1 MD-PLQKHSSALISES-----SPMMSKEPSREVAVATHPSFLQLLMLSLSDLN--PSPGTSYPAH-PKGLRQQ------- 64 
A9Q1J7         1 MD--SSEDNPTWTLES-----LKTSIDDASQAMQVATQLS--EMLATNLSNLT--LNPSIKLP-YLPEYPSQLt------ 62  cattle
1_pfamImport   1 MD-PSQTFDPTLIPES-----SEMLTEEDSQAVSESSHNFS-ETLIKNLSKLS--LNPSTSFPPSLPEGFTQQqdre--- 68 
Q8QZY3         1 MEePSEKVDPMKDPET-----PQKKDEEDALDDTDVLQP---ETLVKVMKKLT--LNPGVK--RSARRRSLRNriaavpv 68  house mouse
XP_038948747   1 MDkSSEKVDPVVNPETqmndgSQREDEEDSPDDSEILQP---ETLVKVMKKLT--LNPSAKPPKYHRHQRVRLriksqpv 75 
XP_003500230   1 MD-PLQKWDPMSISMP-----SRMATVTSSQAASAGSHPSSSEKLSMGLSGLRliRSPGPGVSAPVSEGLLQQ------- 67 
NP_001158155   1 MD-PLQKWDPMSISVP-----SCIATVSSSQEASAAPQPSSSEKLSMGLSILSvsPSPRSSVPASLSEGLFQQ------- 67 
EHB18283       1 MD-PLQKWNPGLISGS-----SQMPTTETSQEGAAASQPSSSEQLMMGLGDLS--ISPGSNPAVPLQEGLFQQ------- 65 
XP_004064247  66 ------RYREEKTlEERRWERLEFLQRKKAFLRHVRRRHRDHMAPYAVGREARI-SPLGDRS-QNR----FRCECRYCQS 133
XP_008246735  66 ------QYREAKT-QQRWYERLPPPQGKKELLGHIRRRHRDHRAPYPASQEAKL-SPSGDRP-QNR----FHCECRYCQS 132
ELK03273      65 ------RHRDGKTlQERQWEKSVAPQRKKAFLEHMRGRRLDHVIPYQVQRETRI-TSSGDGD-QNR----FRSDXXXXQS 132
A9Q1J7        63 -----gQLPSEKTpHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRSDSQRQlQQQEDTEiRSRvr-rFQCTCSYCQF 136 cattle
1_pfamImport  69 --ssfqDMRDGWPlRKRRGVRTLLSVQRE------RMARLRYILINKFSPLARRlKDAELKGvQNDyskpFKCRCSYCVS 140
Q8QZY3        69 enksekIRREVQSaFPKRRVRTLLSVLKDPIAKMRRLVR--------IEQRQKRlEGNE----FERdsepFRCLCTFCHY 136 house mouse
XP_038948747  76 gnrserIMREVQSaFPKTRVRTLLSVLKDPIARMRRFVR--------IEQRQRQlEGNE------RrdepFRCLCTFCHY 141
XP_003500230  68 ------QAREKKAlWQQYWEKQGFPQRKKVFLRHSGRWHWDHMTPYLLARDVRG-SPSGGNT-QNL----QQC-----QG 130
NP_001158155  68 ------QAREKKAlWQQYWEKQGFPQRKKVFLRHSRRWHRDHMAPYLLERDLRG-FPSGDKA-QNQ----LRC-----QG 130
EHB18283      66 ------QHRE-KTlLEQHWERLGFPQKKKAFLGHFRRRHRDHMAPYPVERETRI-SFPGDRA-QNQ----FRCQCRYCQG 132
XP_004064247 134 HRPNLSGIPGESNraphPSSW--ETLVQGLSGLTLSLGT 170
XP_008246735 133 NGPNTSGLSGERG----GASW--ETLVQGLSGLSLSLGT 165
ELK03273     133 HTECLWDACGEERg---PTSFllGNLVQGLSGSTLSLGT 168
A9Q1J7       137 KRN--------------PSDDnyENYYNTTYS-NYAMES 160 cattle
1_pfamImport 141 NNWD-------------PSE-------------NARIGN 153
Q8QZY3       137 QRWD-------------PSE-------------NAKIGK 149 house mouse
XP_038948747 142 QRWD-------------PSE-------------NAKIGQ 154
XP_003500230 131 HVPNIAGMSGDRNtppnPPSW--ETLVQGLNGLTLNLGA 167
NP_001158155 131 HVQNIAGMSGQKNaapnPPSW--EMLVQGLNGLTLSLGa 167
EHB18283     133 HMPNISGVTGERNgnpsPSSW--ETLVQGLSGLTLSLGT 169
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