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Bacterial toxin 28 This entry represents the C-terminal RNase toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an all alpha-helical fold and conserved aspartate and glutamate residues, and K[DE] and [DN]HxxE motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5 or type 7 secretion system. This C-terminal domain cleaves within tRNA anticodon loops, tRNase activity that is stimulated by CysK which stabilizes this domain and allows its binding to the tRNA substrate. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",