Conserved Protein Domain Family
Spem1

?
pfam15670: Spem1 
Spermatid maturation protein 1
Spem1 is a family of mammalian proteins. Proteins are exclusively expressed in the cytoplasm of the last three steps of spermiogenesis in the mouse testis, and male mice deficient in Spem1 are completely infertile because of deformed sperm.
Statistics
?
PSSM-Id: 464793
Aligned: 12 rows
Threshold Bit Score: 376.413
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q68FV4         1 MENQLWQSTLGCCSQYQESPQDAENILFLLLGLIILVNISINVTTVIWHGLQNAIDKMFSRMHQKTAEVQVTECPPKEPQ 80   Norway rat
ELK03808       1 MENQLWYNTLGCCNQYQESPQDAEDFLLLLLGLIILVNIGINVVTVMWHGLQNALDKMINWINQKEENSQACESSPKDAP 80  
XP_011287164   1 MENQLYYDSLGSCSPYQEAPQGANDLLLLLLGLVILVNIGINVVTAMWHGLQNALDKMIHWIHLKNEILQASEGSPKDAP 80  
XP_002718851   1 MENQLWHDNLGCYSECQASPQDAEEILFVLLGLIILVNISINVTTAMWQGLQNILDRMISCIIPKDEV-QPSESPPKDPP 79  
EHB04480       1 MENQLWHDTLGFCSQYQERPQDAEDILFLLLGLIILVNISINMATVMWNGLQNALDKMIYWINQKNEV-QASECSSKYPP 79  
XP_003466222   1 MENQPWRDTLGCCSQHQENPQDPEDILFLLLGLIILVNISINMATVMWHGLQNALDKTIYWINQKSEV-WASDCSAKDPP 79  
EGV93900       1 MENHLWQGTLGGCNQYQESPQDPEDILFLLLGLIILVHISINVTTVMWHGLQNALDKMICWMNQKTNEVQATERPPKEPT 80  
Q0P670         1 MENQLWHNTVRCCNQYQESPHDAEDILLLLLGLIVLVNIGINVATMMWHGLQNALDKMIDWATQKNEI-QASESPPSGPP 79   human
XP_003791318   1 MENQLWHNSVGCCSQYQESPQDAEDILFLLLGLIILVNIGINMATVMWHGLQNALDKMMDCTNQKKDI-QAYESSPKSLP 79  
XP_004760363   1 MENQLWYDNVGCCNQYQEHPQDPEDVLLLLVGLVILVNIAINVVTMMWHGLQNVLDKMISWTNQKNETSQPCESPTKDPP 80   domestic ferret
XP_025284353   1 MENQLWYDNVGCCNQHQEHLQDPEDLLLLLLGLIVLVNIGINVVTVMWHGLQNGLEKVICWINRKNEIlKACESSPKESS 80   dingo
XP_003416943   1 MEDQLWYDTLGCCNQYQESPQDTEDFLLLLLGLIILVNIGINMATVMWHRFQNALDKMICWINQKNDAFQACQNSPRDPC 80   African savann...
Q68FV4        81 pANVQDVHIHCVLDPVQVKMAQPTQCSSSSTHYFRKHSNDr-----------RSRRRYCYPRgslqirq-snqqqscHS- 147  Norway rat
ELK03808      81 -AKAQDVHIHCTLDPVEVKMARPTCCYSSSYHHLHNRSRR------------RHRNRHHRHP---------------CS- 131 
XP_011287164  81 -AKTQDVHIHCALDPVEVKMARPTCHRSSSYRCLRSPRCSc-----------RRHRRCSHRRgrhpg------hhrpCS- 141 
XP_002718851  80 -AKPQDVHIHCTLDPVKVKMTQPIHYSSSSCHRFHNRRNSrnr-------tnSRGRRRSRRQgm-----------plCS- 139 
EHB04480      80 -AKAQDVHVHCILDPVQAKMARPTRYSSSSSHYLLNGHSRr-----------RCRRRFHHHY------------------ 129 
XP_003466222  80 -AKAQDIHVHCTLDPVQVKMAPPTHSSASSGQYPFNCHRRr-----------R--------------------------- 120 
EGV93900      81 -ANVQDVHIHCILDPVQVKMAQPTPCSSSSYHYLRKPYGSr----------rRRRRRWSRYQqgshnr----ypqgrrS- 144 
Q0P670        80 -DKAQDVHIHCILDPVQVKMSRPTQYSSFSCHHFSNHHSSsll------rcvRRRRRRHRRCrr-----------rcCN- 140  human
XP_003791318  80 -AKAKDMQIHCILDPVQVKMTRPTQYSSSSCHHPCKHRHSrrrsrsrsrcgsRSRSRIHHRry------------rrCR- 145 
XP_004760363  81 -AKPQDVHVHCTLEPMEVKLARPVCYPSSSYHHLRSSRSCr----------hRRPRRHRHRPrs-----------rgPRq 138  domestic ferret
XP_025284353  81 -AKAQDVHIHCTLDPVEVKMAPPDCYPSSSYHLGHNSRCCr-----------RPCSRRCRSRrspgprrgpdhhhhpCS- 147  dingo
XP_003416943  81 qAPARDIHIHCTLDPVEVKMAQSTCYSSSSyrlrncnsrrh--------------------------------------- 121  African savann...
Q68FV4       148 --------------------RQQRLRNNRQFSHGYPPFRKQRQSHKASQTRPMPFFDLEDRDSLL--EDDQSCPHPKQP- 204  Norway rat
ELK03808     132 --------------------HQKSPKNHKQFSNNHSVFHSPHHCHKMSQLRTMPSFDLEDLDSFLkeEDDLSFPHPKYP- 190 
XP_011287164 142 --------------------HQWGLRNHRHFPPNRSVFHSHCHNRKMSQLRPVPSFDEDNLDSCLe-EDDLSFPHPKYP- 199 
XP_002718851 140 --------------------HQQRPQNPRRFPRGRPVFRNQHHGYKVPKLRPKPFFDLEDRDSCLeeEEDLSFPHSKYP- 198 
EHB04480     130 --------------------RQQKPQNHKQFPKGCPIFHNQPYGYKTSQPQPVPFFDLEDRDPYLeeLEDPSSPILKYP- 188 
XP_003466222 121 --------------------YQPRPRNHKQFPRGFRIGHNQPYGCKTLKPRPVPFYDLEDQDPYVeeLEDSPFPVLKYPh 180 
EGV93900     145 --------------------HQQRFRNNRQFPHRYQLFRKQPQRYNTSQPRPLPYCDLEDQDPPL--DDDQSCP------ 196 
Q0P670       141 --------------------HQQRPQNYRQIPHSHSVFRNPHRSQKMSQLHRVPFFDQEDPDSYLeeEDNLPFPYPKYP- 199  human
XP_003791318 146 --------------------PQQRTQNRRRFSHGRSGFCNQHHSHKMSQPRPMSYLDGEDQDPYLeeEDDMAFPYPKYP- 204 
XP_004760363 139 rhghghrhhhhhhhhhdscsHQWGLKNQKHLCHNRSAFRSHHQGRKMSQLRVVPSFGG-DLDSYLe-EEDLAFPHPKYP- 215  domestic ferret
XP_025284353 148 --------------------HQWGLKNGRHVRHNRSGFHSHHHSRKMSQLRPVPFFDGED----LeeEDDLAFPHPKCP- 202  dingo
XP_003416943 122 ----------rnhrrrhpfshQQRPKNHRQFRHGCPVFRGLRGSHKMSHLRPMPSLDREDQDSYLedEDGLSFPQPKYP- 190  African savann...
Q68FV4       205 RRSRGGLYKPVRL-ASNAGLWGRQGGILASLPLPSLYLSPEMRRLPKRVEAKSELRLQGF 263  Norway rat
ELK03808     191 RGYRGGLYQQMGL-PSNMGLWGRQGGILASLPPPSLYLSPELRRMPKRVEAKSELRLQSY 249 
XP_011287164 200 RRGCGGLYQPVGL-PSNLGLWGRQGGILASLPPPSLYLSPELRRMPKRVEAKSELRLQSY 258 
XP_002718851 199 RRGWGGFYPRMALpPSSVGLWGRQGGILASLPPPSLYLSPELRRLPKRVEAKSELRLQSY 258 
EHB04480     189 HRCKGGVYQQMDV-PSIVGLWGHQGRNLASLPPPSLYSSPELRRLPKRVEAKSELRLQSY 247 
XP_003466222 181 HRGRGGLYQRKDV-PSIVGLWGRQGGILASLPPPSLYLSPELRRLPRRVQARSELRLQAY 239 
EGV93900     197 HRSWGGFYKPTSM-ASNVGLWGRKGGILASLPLPSIYLSPELRRLPKRVEAKSELRLQAF 255 
Q0P670       200 RRGWGGFYQRAGL-PSNVGLWGHQGGILASLPPPSLYLSPELRCMPKRVEARSELRLQSY 258  human
XP_003791318 205 RGGWGGLYPRMGL-PSNVGLWGRRGGILASLPPPSLYLSPELRRMPKRVEAKSELRLQSY 263 
XP_004760363 216 RGGWGGLYPQRGL-PSNVGLWGRRGGILASLPPPSLYLSPELRRMPKRVEAKSELRLQSc 274  domestic ferret
XP_025284353 203 WGRWRELYQHRGL-PSNLGLWGRQGGILASLPPPSLYLSPELRRLPKRVEAKSELRLQSY 261  dingo
XP_003416943 191 HGGWGGLYPRLGL-PSNLGLWGRQGGILASLPPPSLYMSPELRRMPKRVEAKSELRMQSY 249  African savanna elephant
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap