Conserved Protein Domain Family
UNC80_N

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pfam15778: UNC80_N 
UNC80 N-terminal
UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Statistics
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PSSM-Id: 464864
Aligned: 15 rows
Threshold Bit Score: 281.937
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAQB:GK11761-PB   16 LGLPVSVQTFLWRQIAPFIRPKLGKLHESTCLfcqhapghheskeackSFEKVLVQNIQFGLSPPLTKALGAIPRWRLLQ 95  
EFX80552              20 DIVPLHIQTFLWRQTSSFLRPKIGKMHEASCI----------------SLEKILVQNIRVGLSPNFTEAIRSISRWKFVQ 83  
EEC01341              16 LAVPLPIQTFLWRQTSPFIRPKIGKTHDASAM----------------SFEKVLVQNIQFGLSPSLTVAIKSIRRWRLVR 79  
XP_015782705          14 ESIPLPIQTFLWRQTSPFIRPKFGKQQDALAMeqre---------ackSFEKVLVQNIQFGLSPSLTDAIKSISRWKLVQ 84  
EEN46042               9 gRIPAEVQSFLWRLTSPFVQSKLTKQYEGSCV----------------TLERILVDRRLSGLPPSLQTVISSVPSWSLLN 72  
AAI16431              16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCV----------------SFERVLVENKLHGLSPALSEAIQSISRWELVQ 79  
ESO05347              16 NSIPIPIQTFLWRQTSPFIRQKLAKLCESSAL----------------SFERVIVQNILHGLSPSLCEAIQSISRWKFVC 79  
EEB13523              21 QALPLPIQIFLWRQISPFIRPKLGKLHEASCM----------------SFEKILVQNIQYGLSPSLTDAVSSVPRWRLIQ 84  
XP_028042267          15 EVIPIPVQIFLWRQTTPFVRPRLGKLHDSSCMfcqrapghhelkeackSFEKVLVQNLRLGLSSSLTEAIESIPRWRLIQ 94   wild s...
XP_029340929          17 LPVPINLQNFFWGLTSAFIRPKVGKLHENSCLfcqhtaghhemkeackTFERLLVLDSQIDLPEKLKEEIRLLPRWNIIQ 96   pea aphid
WGS:AAQB:GK11761-PB   96 GALPHVMHACAALLHNRVK--DMQAIGPVETKLLYTMQWILLYAA--------EECADdesge----------------- 148 
EFX80552              84 SSLPHVMLCTAQLIERKDTn-NLQNVGTAASKLLYTLHWTLLDAA--------EECAD---------------------- 132 
EEC01341              80 AALPHVMHCCAALLHARKEs-CLEKLGSAETKLLYTLHWILLDAA--------EECSD---------------------- 128 
XP_015782705          85 ASLPHVMHCCSALLYNRKNs-NLDKLGAAETKLLYTLHWIVLDAA--------EECAD---------------------- 133 
EEN46042              73 AGLPHVMQGCAALLANRNSlgSSDRLRVAETKLLYTLHWILLDAPhewysnvdDECEN---------------------- 130 
AAI16431              80 AALPHVLHCTATLLSNRNKlgHQDKLGVAETKLLHTLHWMLLEAP--------QDCNNdqfggtdrgsswggsssafihq 151 
ESO05347              80 ASFPHVIHCCASILLKRLEtnPEAKFSTSDIKLLYTLHWIILDAA--------GECED---------------------- 129 
EEB13523              85 AAFPHVMHCTATLLQNRKDt-NMQNLGATESKMLYTLHWILLTAA--------EECAD---------------------- 133 
XP_028042267          95 AALPHVMHSLASVLHTRVKd-NMQSLGNVETKLLYTLHWILLDAS--------DECAD---------------------- 143  wild s...
XP_029340929          97 ASFPHILHSTAAILQNRKGt-NIQYIGPIESKLLLILHWIIQDAP--------DECAD---------------------- 145  pea aphid
WGS:AAQB:GK11761-PB  149 -----------dlglGDALPEPKSKPIDQYLFSVPTITLFVYLFAPIIHHLKESDF-QNFRLENGIKLWQGMWDNRAPGA 216 
EFX80552             133 ---------------ADREAGIAPREPFPYIFPLTCIQEFVYLFAPLRHLLKEADL-QNFRLENGLKIWPALWDYRHPNA 196 
EEC01341             129 ---------------AEHAGG---PDPARYVFPISVIQVFVYLFAPLIPFLKQSDFvGSFRLENG-----PLWEFRHPSV 185 
XP_015782705         134 ---------------AEIEQGIN-RPIDHYLLPITTIELFVYLFSPLISYLKNSDFlTSFRLENGHKLWGPLFDYQHPDI 197 
EEN46042             131 --------------------------LETKLFPLETIRNFVHLFAPLVNCIRENDL--TFRLSKGIRIWKPMWEHRQPEV 182 
AAI16431             152 ienqgspgqpcrsssHDEEENNRRK---TFQNSMATVELFVFLFAPLVHRIKESDL--TFRLASGLVIWQPMWEHRQPEV 226 
ESO05347             130 ----------------NEPKKSFKTVKCSYLHSLDTIQLFVFLLIPLVSSLTRSDF-DNLKLENGLRLWEPLWHYQQPNV 192 
EEB13523             134 ---------------ADHENGIFQSSPFYYLFSIPAITLFIYLFAPIYHHLKESDF-QTYRLENGLKMWQALWDYKHPDI 197 
XP_028042267         144 ---------------NDYENGVFYSNPFHYLFSVPTMTLFVFLFAPLSHHLKESDFtNNYRLENGLKMWQAMWEFRHPDA 208  wild s...
XP_029340929         146 ---------------SDYEKGTFQTLPHYYLFNIPTMTLFIYLIAPLINQVKESDLiSN-GLESGLKMWQAFWDNRTPAI 209  pea aphid
WGS:AAQB:GK11761-PB  217 PCFTAPVKPK 226 
EFX80552             197 QCFTAPVRPK 206 
EEC01341             186 PCFTAPVQPH 195 
XP_015782705         198 PSFVAQVKPR 207 
EEN46042             183 SCFCVFIKPK 192 
AAI16431             227 SGFTALVKPI 236 
ESO05347             193 YCFSTPVK-- 200 
EEB13523             198 PCFTAHVKPK 207 
XP_028042267         209 PCFTTLVKPK 218  wild silkworm
XP_029340929         210 ACFSAHCKPK 219  pea aphid
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