Conserved Protein Domain Family
G_path_suppress

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pfam15991: G_path_suppress 
G-protein pathway suppressor
This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Statistics
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PSSM-Id: 318248
View PSSM: pfam15991
Aligned: 14 rows
Threshold Bit Score: 135.775
Threshold Setting Gi: 675861222
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7SZ61         5 LERPKLSNAMARALHKHIMRERERKRQEEEEvdK-MMEQKLKEEEERKRKkemE---ERMSLEETKEQIMKMGVKLQGLQ 80  zebrafish
Q17LP6        19 VVKTEKEEQLWNALKRHIMRERERKKQELEA--E-VEEERLRKEREAREK---Q---DVMTLGETKEQIQMLEKQLQELR 89  yellow fever mo...
EKC23845       6 IDRPKMTKTMYQALKRHIMKERERKKQEQEQ--DaMMMERIKKEEEMRKK---KeqeDSLTLEQTKEQIAQLDKKMEDLK 80  Pacific oyster
XP_009016171  44 IVRPKMTKSTYEALKKYILKDREKKKQEQEQ--D-KEQERLKKEREMKKK---KeeeDNLTLEQTKEQILQLEAKLASLK 117 Helobdella robusta
XP_005997970   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRRKkemE---ERMSLEETKEQIHKLDGKLSALQ 80  coelacanth
XP_001365129   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80  gray short-tail...
XP_003768821   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80  Tasmanian devil
XP_005399580   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80  long-tailed chi...
XP_001688546  18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--E-VEEERLRREREEREK---Q---DVMTLGETKEQILMLEKNLDELR 88  Anopheles gambi...
ETN65319      18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--E-VEEERLRREREEREK---Q---DVMTLGETKEQILILEKNLEELR 88  Anopheles darlingi
Q7SZ61        81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDMTTLTSA----TYQ----------ANmpihpsqhiLSMQaGQVSHg-- 139 zebrafish
Q17LP6        90 NEKQQLFLQLKKVLN-EDDNRKRq-lKE-SvEMFAVHNIpqqqTYL----------PQ---------RTTTaMPPHQqhl 147 yellow fever mo...
EKC23845      81 AEKHDLFSQLKKVLHqEDETRKKaqlKE-QsELQIMQHSt--vLGL----------PH----------AMTgRPILYr-- 135 Pacific oyster
XP_009016171 118 QEKHELFSQLKKVLHqENDLRQRnqlKEqQnEQANLQQQm--lTGLgvnaqffmqqQQqqqr--qkyLSISsq------- 186 Helobdella robusta
XP_005997970  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDMTTLNA-----GYQ----------PGmtvhssqhlINMQgSPVGHs-- 138 coelacanth
XP_001365129  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----TYQ----------QGlavhtgthlLSMQgSPGGHs-- 139 gray short-tail...
XP_003768821  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----AYQ----------QGlavhtgthlLSMQgSPGGHs-- 139 Tasmanian devil
XP_005399580  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----AYQ----------QSltvhtgthlLSMQgSPGGHn-- 139 long-tailed chi...
XP_001688546  89 NEKQQLFLQLKKVLN-EDDNRKRq-mKE---EMFAIQNIpq-qIFL----------PQ---------RSMP--PHQQqhm 141 Anopheles gambi...
ETN65319      89 NEKQQLFLQLKKVLN-EDDNRKRq-mKE---EMMAIQNIpq-qIFL----------PQ---------RSIC--PPHQqhl 141 Anopheles darlingi
Q7SZ61       140 ------------------------rPAVLLGe-RSKQLFQSPVIPArHFQSQPGfsaGGSEhgqYSGAQPGHSpYGVTQt 194 zebrafish
Q17LP6       148 ----------------------ihkTTPPVNvaKRTHSPSP----Q-GYYKQTTaspAYPPpqpQKLEEGRRGpGEVARa 200 yellow fever mo...
EKC23845     136 ------------------------pPQPQM------------VQSS-FPQSQAGp--GYPTqssHAFQQAGYV-P----- 170 Pacific oyster
XP_009016171 187 ------------------------hAPPTQTslKRPRSPSPSTTPS-HYPHFAGsgsSYPNsgsGGGSVGVIG-LGQGY- 239 Helobdella robusta
XP_005997970 139 ------------------------rPGPLLGe-RSKQMFAAPVITGrPYPGQPGftpGTPEhsqYQSSQSGHGaYHVGQs 193 coelacanth
XP_001365129 140 ------------------------rPGTLMSadRAKQMFGPQVLTTrHFVGSTAf-aGTSEhgqFQGSPGGa--YG-AQp 191 gray short-tail...
XP_003768821 140 ------------------------rPGTLMSadRAKQMFGPQVLTTrHFVGSTAf-aGTSEhgqFQGSPGGa--YGAAQp 192 Tasmanian devil
XP_005399580 140 ------------------------rPGTLMAadRAKQMFGPQVLTTrHYVGSAAafaGTPEhgqFQGSPGGa--YGTAQp 193 long-tailed chi...
XP_001688546 142 mhkvsqpevmlsseriftdaypnlqGNPQVNvgKRTHSPSPVQHVQ-GYYKQPNl-nNQPYalpQKS------------- 206 Anopheles gambi...
ETN65319     142 ----------------------ihkGNPQVNvaKRTHSPSSPQHLQ-GYYKQPNl-nNQIYhspQKMDEGRRS-GEVARa 196 Anopheles darlingi
Q7SZ61       195 qhtspfASSQPVPANYASSSQLrgasAFQ------Tmqy------lpHQQ-QGYAVHSHft-sQPGYi---pSAGIPLQK 257 zebrafish
Q17LP6       201 ------VLWNKS--QYCPPGTL----FYP------Anap------qpPN----QPDTRQpq-pQIIYppyqgGLPMSIRQ 251 yellow fever mo...
EKC23845     171 ---------SKSPVKYNPGSQS----AFSsysnpyAhqq------tkQLQeSGFPAYRMq---QPGYittqhGSSIPLQK 228 Pacific oyster
XP_009016171 240 ------TGKGDGPAIKQGSSYT----TVL------Lpqn------hqPPPpNLISQSPS----QQQHsy--iQQQQQQIQ 291 Helobdella robusta
XP_005997970 194 qh--afGGGQPVSMSYTGSQQLrgtpTFP------Tmqy------lsSQQ-SGYAVHGPfa-gQQGF--------IPLQK 249 coelacanth
XP_001365129 192 pp--hyGPTQP---GYSPSQQLrapsAFP------Avqy------lsQPQpQSYAVHGHyqppQTGFlq--pGNALSLQK 252 gray short-tail...
XP_003768821 193 pp--hyGPTQP---GYSPSQQLrapsAFP------Avqy------lsQPQpQSYAVHGHyqptQTGFlq--pGNALSLQK 253 Tasmanian devil
XP_005399580 194 pp--hyGPTQP---AYSPSQQLrapsAFP------Avqy------lsQPQpQPYAVHGHfqptQTGFlq--pSGALSLQK 254 long-tailed chi...
XP_001688546 207 --------------QYCPPVG-----FYP------GappanpqdnrpPP----QP--------QILYpy-qsSLTIPMRQ 248 Anopheles gambi...
ETN65319     197 ------VLWNKS--QYCPPVG-----FYP------Snpp------snPP----QPDVRQp--qQILYpy-qsNLTIPMRQ 244 Anopheles darlingi
Q7SZ61       258 QLEHAn-----------------qQSGFTDSS-PLRPm-HPQALHVSAASLlsTPPI 295 zebrafish
Q17LP6       252 SYQVDla---------------pqPGP-APPG-PQKApeLIKPGPGPGPAPgnVYHI 291 yellow fever mosquito
EKC23845     229 QLEHAn-----------------qQSGFNEEKyKLQQqnSAIRGVAPLPGQqsMMHq 268 Pacific oyster
XP_009016171 292 QQQRQq-----------------aPSPYQIPS-NQKYhqSSSSSSPASGYFpsSNHF 330 Helobdella robusta
XP_005997970 250 QLEHAn-----------------qQSGFTDSS-TLRPmqHPQALH-PNPGLlaASQI 287 coelacanth
XP_001365129 253 QLEHAn-----------------qQSGFSDSS-SLRPm-HPQALH-PTPGLlaTPQL 289 gray short-tailed opossum
XP_003768821 254 QLEHAn-----------------qQsgfsdssslrpmhpqalhptpgllatpqlpvq 293 Tasmanian devil
XP_005399580 255 QMEHAnqqtgfsdsscqlclcslpcapcipklctqhldsspllsclcrcnqqesqal 311 long-tailed chinchilla
XP_001688546 249 YVDIPs-----------------qPGPMVQPK-PEQLivSGKVGPLP-PSQanLYHI 286 Anopheles gambiae str. PEST
ETN65319     245 YVDIPptqqhqqqhqqhqqqhlhqSGLLKQSE-PPHMvqSSKAIMGQ-AAQpnIYHI 299 Anopheles darlingi
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