Conserved Protein Domain Family
Phage_holin_2_3

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pfam16080: Phage_holin_2_3 
Bacteriophage holin family HP1
Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.
Statistics
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PSSM-Id: 318330
View PSSM: pfam16080
Aligned: 14 rows
Threshold Bit Score: 55.7728
Threshold Setting Gi: 123530177
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2S7H4         3 DKAASAAAYASSAVATLFGL--------SLSQVVALGGLLIAAATFVMNWYYKQKHLdlaREQ 57  Hahella chejuensis KCTC 2396
Q0WF59        45 EKYTSGSSYGWGAFTVMLGSl-------SLNEWAIVVGIACTVGTFTINWHYKRKEFqlrEKA 100 Yersinia pestis
Q2NV04        23 EKLTTGSAYSWALVTCLLGVf-------SLSEWALITGIACTLATFLLNWIYRHKEYrfrTKR 78  Sodalis glossinidius str. 'morsi...
P51727         3 SKIDSAIPFIGSLTALISGY--------SLHEWASLFGILFGAVSVWIAYRKYKEDVqarKDE 57  Haemophilus phage HP1c1
ACQ67704       5 EKYTTGTAYGASATTFLCGAl-------SLSEWALVTGIICSLLTVGLNWYYRHKEYrfrTRN 60  Candidatus Hamiltonella defensa ...
ACQ68086       5 EKYTTGTAYGASATTFLCGAl-------SLSEWALVTGIICSVLTVGLNWYYRHKEYryrTRN 60  Candidatus Hamiltonella defensa ...
AAC45168       7 KNSETTGAYVGSAIAIYSGf--------TLADWAAIFGILFGLFTMLINWYYKNKEIklkETA 61  Histophilus somni
WP_013200148   6 DRVVSFLSYLPSAFLTTLGLf-------SLTQWATLIGIVLGILTYRLNKRHKRRVEleeEKR 61  Erwinia billingiae
WP_024910291   2 QEKSSLAAYISSGSLVVIGKigawfndlTLNEWAIVIGIIMATVTCAANIYFQRRQTraiEKA 64  Serratia multitudinisentens
WP_004238694   5 DKYSSPTAYAWGLITSAFGIl-------SLDQWAIVAGIICTVGTFLVNWYYKRKEFqlkAGE 60  Morganella morganii
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