Conserved Protein Domain Family
HIP1_clath_bdg

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pfam16515: HIP1_clath_bdg 
Clathrin-binding domain of Huntingtin-interacting protein 1
HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.
Statistics
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PSSM-Id: 465154
Aligned: 25 rows
Threshold Bit Score: 92.3796
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021335154  453 HADLMRKNAEMLKQKSSGQQAQEELLAYRQQVAQEMQQLTLDNNSKLEAQRAEIERLKQELVSGRAEVSQVHNALQSKEK 532 
XP_007239764  467 HAELLRKSADTVKMLSATQQTQEEVERTKQQLAFEVERAKQESDMKLEEQKFEMDKLRRDLEEKILEIQRMKGTLQTCEK 546 
NP_001077034  467 HAELLRKSADTVKMLSATQQTQEEIERTKQQLAFEVDRVKQESDMKFDEQKFEMDKLKRELEAKAAEIQKVRSSLQTSEM 546 
XP_003451671  468 HAELLRKSADTVKMLSVTQQTQEEVERTKQQLTFEMDRVKQEADMKMEEQRFEVERVKRELEEKMAEVTRIKATLQSSEK 547 
XP_003222791  459 HAELLRKNADTAKQLTVTQQSQEQVARVKEQLAFQMEQAKRESEMKLEDQILQMEQLKREMESKKDELAQLQESLGRSKQ 538 
XP_027325606  459 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLEFQVEQVKREAEMKLEDQSVQMEQLRRELDARRDELDQAQSSLSHAKQ 538 
NP_001128235  462 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKMEEQSDQLEKLKRELVAKAGELAHAQEALSRTEQ 541 
XP_005989022  473 HAELLRKNADTAKQLTATQQVQEDVARTIETLQFEVDQGKRESEMKLEEQTFLTEQLKQELEARKEELANVQLSLNSSEQ 552 
XP_029296185  468 HAELLRKSADTVRMLSATQQTQEEVERTKYQLSFEVDRIKQEADMKLEEQKFEMEKLKRELEEKLAEMMRLKGTLQSSEM 547  Cottoperca gobio
XP_007250344  452 HADLMRKNTDTVKQLTSTQHVQEELVRAKQQMAEELEKLKQENSMMLEAQKAEIVRLKQELLSGKAEITQVQSALQTKEK 531  Mexican tetra
XP_021335154  533 VSVRMSLCV---------I 542 
XP_007239764  547 ASDQINSSMtslqvekerL 565 
NP_001077034  547 TGVHMNSSMaalqaekdrL 565 
XP_003451671  548 TSEHMNSSMtalqaekerL 566 
XP_003222791  539 LGSDLNSQLdalqsekdtL 557 
XP_027325606  539 AGSELSAQLetlqaekeqL 557 
NP_001128235  542 SGSELSSRLdtlnaekeaL 560 
XP_005989022  553 AGSQLKSRLqelqdenstF 571 
XP_029296185  548 TSEQMNSSVtalqaekerL 566  Cottoperca gobio
XP_007250344  532 SGDQLSSLLvglqtekemL 550  Mexican tetra
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