4OH8


Conserved Protein Domain Family
Nore1-SARAH
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pfam16517: Nore1-SARAH 
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Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
The Nore1-SARAH, C-terminal, domain of Nore1, the tumour-suppressor, a novel Ras effector, has a characteriztic coiled-coil structure. It is a small helical module that is important in signal-transduction networks. The recombinant SARAH domain of Nore1 crystallizes as an anti-parallel homodimer with representative characteriztics of coiled coils. The central function of the SARAH domain seems to be the mediation of homo- and hetero-oligomerization between SARAH domain-containing proteins. Nore1 forms homo- and hetero complexes through its C-terminal SARAH (Sav/Rassf/Hpo) domain.
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Statistics
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PSSM-Id: 435392
Aligned: 55 rows
Threshold Bit Score: 28.2338
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OH8_B         8 AFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 47 
XP_015784958 456 NFSNVELQVFLEKYHEQEQNEIEKVKNKYNILKETLEQLI 495
5_pfamImport   1 KFEMPVLQSFITKLKEEEDREVLKLRSSFTSIKSIKHKEK 40 
NP_001002195 269 KFELPVLQSFIAKLQEEEEREMQKLKTRYAEMQRIIKRCM 308
XP_003440158 294 NLELPILEKVLQKLKDEENREIQRIENKYKHQKRVLSNML 333
XP_014353445 255 KFDLPLLQSILLKLNEEEKRETEKIIKKYTAEKNILIQHL 294
XP_007495728 413 HCHLSLLESILQKLNEEEAREIKKIITKFNTEKAFILKHL 452
XP_017825983 286 NFHFTLLESILQRLNEEEKREIQRIVAKFNKEKAIIQKCL 325
XP_008265978 287 NFHFSLLESILQRLNDEEKREIQQTIRKFNTEKAIIQQCL 326
Q6DIW3       289 KFSLPLLESFLKKLNEEEEREIQRTMDKFLKEKAILLQCL 328 tropical clawed frog
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