4HPL


Conserved Protein Domain Family
PUFD
?
pfam16553: PUFD 
Click on image for an interactive view with Cn3D
BCORL-PCGF1-binding domain
PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Links
?
Statistics
?
PSSM-Id: 465171
Aligned: 13 rows
Threshold Bit Score: 201.841
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4HPL_A          5 SDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCS--K 82  
XP_005992040 1490 DSPFLFEFSDKPLLPCYNIQVSFSRGPCNWLLLSEVLKKLKLSARIFQARFPHFEVVSIAETEFHKQVSTSQLLHQP--E 1567
XP_012823564 1462 EDNFLFEFSDRPLLSCYNLHVSLTSGPSNWLLFSDVLKRLKLSSRIFQARYPHFEIASMQKKEFTKQVLTSQLLTPT--E 1539
XP_008118431 1393 SDRFVFEFSDKQLLPCYNLQVSVSRGPCNWFIFSDVLKRLKLSSRIFQARFPHFEVATLPKAEFQHQLSLSQVLAPE--E 1470
XP_008105602 1471 SDIFEFEFSDVPLLPCFNIQVSLSQGPRNWLLLSDVAKRLKMSPRIFCCSFPSVEVVSITEAEFFKQVSLSQLFSCE--K 1548
XP_023374901 1587 SDVFEFEFSESPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCS--K 1664
XP_005995319 1640 DDVFEFEFSDSPLLPCYNIQVSLSQGPRNWLLFCDVIKRLKMSTRTFRSHFPHLEVVTIAGAEFHRQVSLSQLSSTP--E 1717
XP_012811910 1548 MDAFEFEFSDSPLLPCYNIQVSLSQGPRNWMLLSEVTKRLKMSSQTFTAENPHLEIVTITEAEFYKQVSLSQLFSSP--E 1625
XP_005173372 1381 ADCLLFEFSSEPLLSCYHVQVSLTQGFCNWFLLADVLKRLKMSARIFRARYPQFEVVNIAQAELWKQVSVSQTCSPP--D 1458
XP_009513588   64 SDVFEFEFSDEPPLPCYNIQVCLSQGPRNWLLLSDVVKRLKMSSRIFRCNFPNLEVVTITEAEFYKQTSLSQLFSCA--T 141  great cormorant
XP_016153879 1468 ADNFMFEFSDKPLLPSYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEVATLPRAEFQRQVSLSQVLAQE--E 1545 Collared flyc...
XP_023184145 1368 KDCLVFEFSSEPLLPCYHVQVSLTQGFCNWFLLTDVLKRLKMSARIFRARYPHFEVVSLSQAELWRQVSVSQVGFPR--K 1445 southern plat...
TNM94061     1844 REVFEFELSDRPLLPCYNVQVSLSQGPRNWLLLSDVLGRLRMTSRSFRRLFPQLNVQSIPEDEFYRQASLSQLLTGPdeQ 1923 Takifugu bima...

4HPL_A         83 DLEAFN-----PESKELLDLVEFTNEIQTLLGSSVEWLHPS 118 
XP_005992040 1568 DLHLSN-----PKSCNSVELIRYVPELLHLLGSTVEFLTGT 1603
XP_012823564 1540 GLDLWP-----QDMGDIVELVKYEPELLQLLGSAVEFQGVS 1575
XP_008118431 1471 IQEHMVp----PGAAETVELVRYEPELVRLLGSEVAFEAWS 1507
XP_008105602 1549 DLEAFN-----PDSKELLDLVEFTSEMQSLLGSSLEGLHPD 1584
XP_023374901 1665 DLEAFN-----PESKELLDLVEFTSELQTMLGSSVEWLHPN 1700
XP_005995319 1718 ELQSFN-----PESKELLDLIEFTDELKALLGSSLEWLHPE 1753
XP_012811910 1626 GLEGFS-----PDSREMVDLVEFTNELQTLLGSSIEWIDPE 1661
XP_005173372 1459 ELQPEDd----EDGEETVELVRCVPELQGLLGSSIQILRDD 1495
XP_009513588  142 DLEAFN-----PESKELLDLVEFTSELKTLLGSSLHWLHPH 177  great cormorant
XP_016153879 1546 VPASPEp---aPGAAETVELVHYEPELLQLLGSAVEYQAWS 1583 Collared flycatcher
XP_023184145 1446 RGGGGDdeeeeEDEEGPVELVCCVPELQRLLGSSVHILPEE 1486 southern platyfish
TNM94061     1924 DLASFR-----PDIKDPLELIEATPELAGMLGSSLEFVDTR 1959 Takifugu bimaculatus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap