Conserved Protein Domain Family
GIT_CC
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pfam16559: GIT_CC 
GIT coiled-coil Rho guanine nucleotide exchange factor
GIT-CC is the coiled-coil region of GIT (G protein-coupled receptor kinase-interacting) proteins. This coiled-coil region is the surface that associates with the equivalent binding-region on beta-PIX, or p21-activated kinase-interacting exchange factor proteins. Both GIT and PIX complex together to form a scaffold for the formation of multi-protein assemblies. On its own the GIT-CC region assembles into a parallel two-stranded CC in the asymmetric unit. Similarly the PIX coiled-coil region assembles into a trimer. At least in vitro the two regions associate together into a stable heteropentameric complex that consists of one PIX trimer and one GIT dimer.
Links
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Statistics
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PSSM-Id: 465174
Aligned: 13 rows
Threshold Bit Score: 80.5782
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFO26702     442 KSDDSGDLLQetGPVMIDDFLELKEKVANAESTLTAVQQANTQILRMLTHLQSSVDRLNADNADVHDE 509
XP_025764717 417 KSSESSDLSD--GPITVQEFMEVKSALTASEAKIQQLLKVNCHLSEELRLMQSKLNSLQTENTTLRWQ 482
XP_011614053 413 KSLDS-DLSD--GPITMQEYVDLKNALTASEVKIQHLMKANNNLSDELRLMQKKLHTLQSENSSLRRQ 477
EHB04762     468 KSLDS-DLSD--GPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSSLRKQ 532
XP_022521973 412 KSLDS-DQSD--GPVTVQDFLEVKNALLASEAKIEQLMKANVSLTEELRLLQKKLLSLQSENSSLRSQ 476
XP_001636194 412 KGTSTSFVLE--DTVPMENYLELKRALATAEARIQQLLQVNASMSQGIQELQSVQIPLAPNEDDDDDD 477
EFX84315     438 KGLQDLNQQK--SGVSVEAYIGIKEQLSLSNVRMQELLASNTNMQTQIAQLQNMVQTLVQENNQLKTQ 503
EEN65505     415 ESMASSDLSD--GPITLEEYLQVKKALAASDARVQQLIQVKQQQQQEISLLQSMVQKLMQENANLRTQ 480
Q9Z272       418 RSMDSSDLSD--GAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRKLQREIHKLQAENLQLRQP 483 Norway rat
XP_010572242  68 RSMDSSDLSD--GPITLQEYLEVKKALAASEAKVQQLMKVNNSLSDELRRLQREIHKLQAENTQIRQQ 133
NP_001016917 414 KSLEA-ELSD--GSVTVQEFLELKNALVASESKIQQLMKANNNLSDELRVMQKKLQTLQCENTNLRRQ 478
TNN23643       1 --MDSSDLSD--GPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEvggkegrreggkkr 64  Tanaka's snailfish
TDH12875     403 KSLDS-DLSD--GPVTVHEYMEVKNALSASEAKIQHLMKANNSLSDELRLMQKKLQSLQSENTSLRRH 467 yellow perch
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