Conserved Protein Domain Family
Caskin1-CID
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pfam16600: Caskin1-CID 
Caskin1 CASK-interaction domain
The Caskin1 protein interacts with the CASK protein via this region.CASK and Caskin1 are synaptic scaffolding proteins. The binding motif on human Caskin1 is EEIWVLRK. A similar motif is found on protein MINT1 and protein TIAM1, both shown to be able to bind to CASK though the motif. MINT1 and TIAM1 are not part of this family. This region is predicted to be natively unstructured.
Links
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Statistics
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PSSM-Id: 465190
Aligned: 5 rows
Threshold Bit Score: 40.0313
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_027877794  456 EEIWVLRKPVA-GGDRSsvGSSGSVTSVRSSGSGQSAtn------------------------aaHILHAQAEGVKLLAT 510 
XP_011475521  459 EDIWVLRKPLA-GGERS--GSTGSLGSVRSSSSLQSSgnthvlttpapsphpapttglnthglnaPGLHAQSEGVKLLAT 535 
1_pfamImport    1 EEIWVLRKSGApAGDRSsvGSTGSVGSTRSAGSGQSS--------------------------------TGGDGPRVWST 48  
XP_003790846  373 EEIWVLRKPFA-GGDRSssSSVSSVAGGRGSGG--------------------------------HALHAGSEGVKLLAT 419 
XP_015215772  339 ssiveviskrA-GGDRSsvGSSGSVASARSSGSGQSAgg------------------------svHALHAQAEGVKLLAT 393  spotted gar

XP_027877794  511 VLSQ 514 
XP_011475521  536 VLSQ 539 
1_pfamImport   49 CIRS 52  
XP_003790846  420 VLSQ 423 
XP_015215772  394 VLSQ 397  spotted gar
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