Conserved Protein Domain Family
NEXCaM_BD

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pfam16644: NEXCaM_BD 
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.
Statistics
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PSSM-Id: 465214
Aligned: 16 rows
Threshold Bit Score: 117.119
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003765730 571 STGFMIPLQAQR-------IQGTK-RLSP------EDVKSMRDILTHNMYQVRQRTLSY-NKYNLSTETSEKQAKEILIR 635
XP_023193153 568 AAPSLVSLQGEK-------KESTT----PkktfmaEDLKNMHDLLSKNMYKIRQRTVAFtSKHALP---NDNQPREILIR 633
XP_005457888 567 AAPSIVSLYEEK-------KSSSK----PqkkflaADLKNMHDILSKNMYKIRERTVAYrGKHALP---NDNHTREILIR 632
XP_007491444 594 KMPSPVSIQNIH-------PKTTD-RIMPkl--skDKEEEIRNILRNNLQKTRQRLKSY-NRHTLVADPYEEAWNQMLLR 662
XP_005420098 440 KVPSSVSLSDYH-------EGKIK-PLSP------TEMENMREILTKNLYQIRHRTMSY-NRHSLAADASEKQAKEILIR 504
3_pfamImport   1 TVPSFASLNDCR-------EEKVR-KLTP------GEMDEIREILSRNLYQIRQRTLSY-NRSTGVVLSRERLQPEDCLK 65 
XP_604493    573 TVPSFASLNDCR-------EEKVR-KLTP------GEMDEIREILSRNLYQIRQRTLSY-NRHNLTADTSERQAKEILIR 637
XP_008114344 561 TVPSLASFSELQ-------EEEKRiPSYP------ALTDDIRDILTKNLYQIRQRTPSY-NRYSLAEDANEKQAKEILIR 626
EDL99169     566 SVASPTPYQSER-------IQGIK-RLSP------EDVESMRDILTRNMYQVRQRTLSY-NKYNLKPQTSEKQAKEILIR 630
XP_023819784 402 ALPSTVSIQNIQpkkpppaPEPRE-RVLPql--pkSREEEIRKILRSNLQRTRQRLRSY-NRHTLVADPYEEGLNDL-LK 476 Japanese medaka
XP_003765730 636 RQHTFRESLR---KGNSLPwGKPSGIKNIRYLSFPYSNPHSANRETGT 680
XP_023193153 634 RHANIRRSLR---HGSFQS----TIPRSQKYFSLPTGQNLGSKYSSVR 674
XP_005457888 633 RHVSIRRSLR---PGSFQS--SSYVPRTHKYFSLPAGKSLESTFPAAR 675
XP_007491444 663 RQRALQMEQK---I--------------NTFLTVPPQTPGSPTLNRAR 693
XP_005420098 505 RRHSLRESLR---KTNSLSrERPAAANTKRFLSLPKNTKLPEKLRVRN 549
3_pfamImport  66 MLHFMCEMWQ---HQLKVKeTRQASTSTSRYLSLPKNTKLPEKLQKKK 110
XP_604493    638 RRHSLRESIR---KDSSLNrEHRASTSTSRYLSLPKNTKLPEKLQKKK 682
XP_008114344 627 RRHSLRESIR---KSNSLS--RPPASKAPRYLSLPKNTKLAEKVRKRN 669
EDL99169     631 RQNTLRESLR---KGQSLPwVKPAGTKNFRYLSFPYSNPQPARRGARA 675
XP_023819784 477 KQKMFELEKKikeM--------------NNYLSVPVATSDSPTLRRAR 510 Japanese medaka
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