3SC0


Conserved Protein Domain Family
MMACHC

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pfam16690: MMACHC 
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Methylmalonic aciduria and homocystinuria type C family
Statistics
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PSSM-Id: 318822
View PSSM: pfam16690
Aligned: 27 rows
Threshold Bit Score: 198.628
Threshold Setting Gi: 802672603
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SC0_A        23 GFEVYPFQVAWYNELL--PPAFHLPLPGPTLAFLVLSTPAMFDRALKPFL-----------------QS-CHL------- 75  human
Q7Z144        24 GFESHMFKIGSYNEAVgeSSPFALPYDDSTMALLILSTPDMFDVAFRKWV-----------------VQkTMD------- 79  Caenorhabditis ...
EKC18165      13 dLEFNPRLIGWYNEHV--QEVFRLSYPADTLGLLVISTPDMFERAFIPFVk----------------EQ-EEC------- 66  Pacific oyster
XP_011405503  24 GLEAHPFKIQWYNDKV--SDSFKLPYNGDTLAVLIISAPKMFEELLKPFIlggkykregfnalkdeeNE-RKE------- 93  Amphimedon quee...
XP_009009623  20 GLEAYPFKIGWYNDEV--HKSFHLEYDYDTLAFSLVSLPKMFDILFCPFL-----------------EQ-WDG------- 72  Helobdella robusta
XP_002115419  20 GFECAPFKISWYNDQV--DDHFKLKCNQNALAFIIISLPQMFDKTFKTFI-----------------MK-KYNidnfple 79  Trichoplax adha...
ERG79169      20 GFECHRFKVGSYNALV--ASEFQLAYEADVMAVVVLNTPSFLETTFKHWL-----------------QSqKGE------- 73  pig roundworm
ERG87721      76 GFEWYRFKVGSHNAIV--QENVRLKFEDDVLGVLVLNTPSFFETTFKEWL-----------------RQhCNP------- 129 pig roundworm
KKA67060         -------------------------------------------------------------------------------- Pristionchus pa...
XP_001631400   1 ------FQIGWYNNQVt-HKQFQFPFDPDTLAFVIISTPEMFEKGFKPFI-----------------TD-ADC------- 48  starlet sea ane...
3SC0_A        76 ----------------RML---------TDPVDQCVAYHLGRVRESLPELQ--IEIIADYEVHPNRRPKILAQTAAHVAG 128 human
Q7Z144        80 ----------------FGSfdev-cemvSSPIQSFLEDRLEIMSEKLRKVEenFEILHDYSMTPQRRPKILMQTCGHVAG 142 Caenorhabditis ...
EKC18165      67 ----------------DGI---------RDPIDQCVAYYFNKVKEDFPEYE--VESIHDYEMHHSRRPKILVQTVGHVSG 119 Pacific oyster
XP_011405503  94 ----------------EGG---------SDPLDQCFRDVFNKLQTHFSQYK--TTFIQDYELHHNRRPKILLQTAGHVSG 146 Amphimedon quee...
XP_009009623  73 ----------------KGG---------NDALDECMRFYLNKLKSNF--TD--VELIHDFEFHHSKRPKVLVQTAGHVSG 123 Helobdella robusta
XP_002115419  80 dkaewneeekeefsynQNV---------YDPLDQCMLDYFQKIRNHFPDHQ--LHIIRDFEMDASHRPKVLVQTAGHVAG 148 Trichoplax adha...
ERG79169      74 ----------------HEAlneliakfgANPLQAYFIRKFGQVIKDLRPVE--ARVIHDFDFNNNCTPKVLLTTCGMVSG 135 pig roundworm
ERG87721     130 ----------------GEGvddvktkvgPHPVETFFNWKFMQIEMHLSPIR--VVSICDFEPVRHRLPAVSLPACGHVSG 191 pig roundworm
KKA67060       1 -------------------------------------------------------------mndnliiKILMCTCGHVAG 19  Pristionchus pa...
XP_001631400  49 ----------------LGS---------RDPIDECMAAFFLKVKQAFPCHE--IDAIHDFELHPNRRPKVLVQTAAHAAG 101 starlet sea ane...
3SC0_A       129 AAYYYqrq-dvEADPW-GNQ------------RISGVCIHPRFGGWFAIRGVVLLPGIEVP--D-LPPRKPHDCVPTRAD 191 human
Q7Z144       143 AAFYYq-----PCHFQeDGVtwppagrmgpnlKFIGLSLHPIYGGHFAFRSVLIFPNVKIP--E-FCEKEPRPILTASED 214 Caenorhabditis ...
EKC18165     120 AVYYYqks-dvTDQPWpTDK------------KICGVCYHPVYGGWFGLRGVLIFKDVLCP--P-LQQPLPKDVIPSQEK 183 Pacific oyster
XP_011405503 147 SAYYYqrg-dvPRAPWgEDK------------PIYGVSVHPRYGGWFAFRGVLIFEDIRVKgeE-LEYKDPIDCVSKREK 212 Amphimedon quee...
XP_009009623 124 GVFYFqrkdikHSDPWpENR------------KICGVCLHPKYGGWFGLRGILIFKNVKVP--N-LMKKE-LECFLSNEQ 187 Helobdella robusta
XP_002115419 149 AVRYYqrc-dvHDDPWdESQ------------RIYGTCVHPKYGGWFALRGVIIFEDVNAN--K-LAQVDPPDMIKTDQD 212 Trichoplax adha...
ERG79169     136 AAYFYr--------PLeSGKsridpv-thvekRSMGLSLHPKFGGHFGFRAVFIFPRVHLP--AdFKEKTAPMRLDTPEK 204 pig roundworm
ERG87721     192 AAYFYh-----PNHPVtGEKiy-----------pqGLSLHPKYGGYFAFRGVIIFPDVHLA--AtFKEPQPLKTLDTDAK 253 pig roundworm
KKA67060      20 AAYYYrqs-dpTLSETkDGKkwdpkp-aaanlKFIGLSLHSDFGGHFAFRSVLIFPHISLP--SsFKEREPVAVLHTIDE 95  Pristionchus pa...
XP_001631400 102 AAYFYqrk-diTDDPWpPTQ------------RICGVCVHPKYGGWFAIRGVLIFKTFKYP--D-LPRKQPMDVVVGDEK 165 starlet sea ane...
3SC0_A       192 RIALLEGFNFHWRDWTYRDA---VT-PQERYSEEQKAYFSTPPAQRLALL 237 human
Q7Z144       215 VRTALEKFNYNWKDSGFRDF---GN-PTRRYSTTQMEFFGRPVAERWEVL 260 Caenorhabditis elegans
EKC18165     184 RVELLNKFNFHWQDWTFRDL---LP-VRQRYSQEQIMYFSTKPKDRPELI 229 Pacific oyster
XP_011405503 213 RIELLEEFNYHWEEWRYRDIldgGD-VEDRYSEEQKEYFGTLPKDRHKLV 261 Amphimedon queenslandica
XP_009009623 188 IISLLDKFNNSWRDGTFRDV---IE-PLERYSTLQQKYFNVTPDERLELI 233 Helobdella robusta
XP_002115419 213 RIRLLNLYNFHWRDWSFRDV---LPgVVARYSDEQKTFFSTPPSQRPQIL 259 Trichoplax adhaerens
ERG79169     205 QKEALDLFNNSWKDGRFRDC---GD-PLERYSELQLKYFSTPPMARWQLI 250 pig roundworm
ERG87721     254 VLEALELFNKHWMDNRYRDC---GD-PIEKYSALQLKYFNTVSRRRWRLI 299 pig roundworm
KKA67060      96 IKDALEKFNYAWKDSRFRDC---GN-PKERYSSTQMEYFGKPPSERWEVI 141 Pristionchus pacificus
XP_001631400 166 RIELLEKFNFHWEDWSFRDV---VP-SERKYSDQQIKYFSTLPVNRKDLL 211 starlet sea anemone
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