4H8S,5C5B,4CKG


Conserved Protein Domain Family
BAR_3
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pfam16746: BAR_3 
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BAR domain of APPL family
BAR_12 is the BAR coiled-coil domain at the N-terminus of APPL or adaptor protein containing PH domain, PTB domain, and leucine zipper motif proteins in higher eukaryotes. This BAR domain contains four helices whereas the other classical BAR domains contain only three helices. The first three helices form an antiparallel coiled-coil, while the fourth helix, is unique to APPL1. BAR domains take part in many varied biological processes such as fission of synaptic vesicles, endocytosis, regulation of the actin cytoskeleton, transcriptional repression, cell-cell fusion, apoptosis, secretory vesicle fusion, and tissue differentiation.
Links
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Statistics
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PSSM-Id: 465256
Aligned: 47 rows
Threshold Bit Score: 208.569
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4H8S_A         30 LLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNfalgKGDEEVI--- 106 
NP_741164       6 LEFSDSISDSPWFRQNLHDHEVALDDAFKNIKLIENQCKELIACTKKLSTAQRAFAKTLSEFKFET----VGTNQTDder 81  
EDV92192       14 LEFEECIVDSPEFRDNLNRHEKELDHTSQQIKRIIKEVKDLMSAAKVLSTRMKQLAILLNDFNFEC----IGTAQTDden 89  
XP_003436889    7 LEFIDCLIDSPNFRENLNKHEKELDKTSQQIKRIIKEIKDLLAAAKSLSRAQRTLSRSLKEFNFEC----IGSTQTDdeq 82  
XP_002416638    6 LEFTDCLTDSPYFRENLHAHENELDRTSQAIKGIIKEVKELLTAAKSLSRAQRSLANTFMNFRLEC----IGNSQTDdei 81  
Q99J31          6 LEFSDCYLDSPDFRQRLKYYEEELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQSFQFDF----IGDTLTDdei 81   house mouse
XP_023817931    6 LEFSDCYLDSPQFRERLKSHEAELDKTNKFIKELIKDGKALVQALKSLSTAKRKFADSLNDFKFQC----IGDAETDdei 81  
XP_023813420    6 LEFSECYLDSPSFREKIKAHEAELDKTNRFIKELYKDGKNLINATKQLGMAQRKFAQCLGEFQFEY----IGDAKTDder 81  
A1A4S6          6 LEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEF----IGDAVTDder 81   human
TNM84877        6 LEFSDSFLDSPEFRERLQCHEIELERTNSFIKDLIKDGNMLVSALKSLSIAVQRFSQSLQEFQFEC----IGDAETDdei 81   Takifugu bima...

4H8S_A        107 ---STLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTE-VSTLKDLFGLASNEHDLSMAKYSRLPKKkENEKV 182 
NP_741164      82 fiaTCLKEFGSLINQVEDERMKLVGQAEESYLEPIKKFRTEAIGRtLKEEKNKYDKESSKFYQTLEKHLHLSTV-RNNDF 160 
EDV92192       90 vicESLKRFGAIIGTIEDEREKMLTLADKHIIESLEDFRKKQIGG-VKENKKKFDKKTEKFCQSQERFLNMSTKkPENTI 168 
XP_003436889   83 viaDSLKQFSKLISAIEEERDNMLDRAHEQILLPLEEFRKLHIGG-VKENKKKYDKKTAKFCQAQERFLNMSTKkSSP-- 159 
XP_002416638   82 viaGSLKEFGRLLTTIEDERDRMLENAHELFIAPIEKFRKDHIGE-AKERKKKFDKETAKYCQSLERYLGLSTKkGDTQL 160 
Q99J31         82 niaESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGF-TKERKKKFEKDGERFYSLLDRHLHLSSKkKESQL 160  house mouse
XP_023817931   82 ciaKSLQEFAAVLQNLEDERTRMIENANDVLILPLERFRKEQISA-AKEAKKKYDKETEKYCGVLEKHLSLSAKkKEAHL 160 
XP_023813420   82 cidESVQEFSSFLKNLEDQRELMMRNITETLMKPLEKFRKDQLGA-VRAERKKYEKETEKYYSSLEKLLNMSAKkKEPQL 160 
A1A4S6         82 cidASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGA-VKEEKKKFDKETEKNYSLIDKHLNLSAKkKDSHL 160  human
TNM84877       82 siaQSLKEFSQLLSTMEEERKRLIQNADDVLISPLERFRKEQIGA-VKEGKKQFDKETERYYSVLEKHLSLSSKkKDSHL 160  Takifugu bima...

4H8S_A        183 KtEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFsKRMDSFLSSVADMVQS--IQ 260 
NP_741164     161 R-AADAQLETQQKNFFQASLQYVAEVQSVQERMRFEFVETLGSYVYSWLSFFHVGSVIH-QDFKPFLDNVQTKVQK--TK 236 
EDV92192      169 Q-EADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVFYHTAHEQA-EDHRDYLQDLRHKVQK--TR 244 
XP_003436889  160 --AADASLGMLEREYLRESLSYVLSIQEVQERIKFEFVEIILRFISDWLVFYHLGHEVA-EDAKEYLSDLQLKVQK--TR 234 
XP_002416638  161 K-EAFAVLEMEKRHFFKASLEYVLMLQKVQERKKTEFVETILRFMYGWLTFYHQGHEVA-KEFNSFNTDLQVRLQKasTR 238 
Q99J31        161 L-EADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELT-QDFLPYKQQLQLSLQN--TR 236  house mouse
XP_023817931  161 H-EADNQVDNVRQHFYEVSLEYVFKVQEVQERKMFDFVEPLLAFLQGLFTYYHHGYELA-KDFNHFKTDLTISIQN--TR 236 
XP_023813420  161 Q-EADIQVETMRQHFQEESLDYVCKLQEIQERKKFECVEPILAFFQTVFTFYHQGYELA-KDFEYYKRSLQISIQN--TR 236 
A1A4S6        161 Q-EADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELA-KDFNHYKMELQINIQN--TR 236  human
TNM84877      161 Q-EADTQMSKDRQVFYDASLQYVFKIQEVQERKKFEFVEPLLAFLQGLFTFYHEGYELA-SEFEPYKQQLQFNLQN--A- 235  Takifugu bima...

4H8S_A        261 V---E--LEAEAEKM 270 
NP_741164     237 EnynA--TNAEAEEL 249 
EDV92192      245 EnfeE--AREKVTEL 257 
XP_003436889  235 EnfdE--TRQKAQEL 247 
XP_002416638  239 EnfeA--THCEAEHL 251 
Q99J31        237 NhfsS--TREEMEEL 249  house mouse
XP_023817931  237 NrfeS--TRSEVESL 249 
XP_023813420  237 SrfeG--ARSEVYEL 249 
A1A4S6        237 NrfeG--TRSEVEEL 249  human
TNM84877      236 Rn-nFesTRAEVERL 249  Takifugu bimaculatus
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