Conserved Protein Domain Family
MCM3AP_GANP

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pfam16769: MCM3AP_GANP 
MCM3AP domain of GANP
MCM3AP_GANP is the C-terminal domain of germinal centre-associated proteins, GANPs in higher eukaryotes. GANP forms part of the TREX-2 complex which in higher eukaryotes requires the MCM3AP domain of GANP to facilitate its localization to the Nuclear pore complex and nuclear envelope. TREX-2 complex links transcription with nuclear messenger RNA export.
Statistics
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PSSM-Id: 465265
Aligned: 18 rows
Threshold Bit Score: 800.024
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006636742  1450 AFPAAPCCVDPRFKLKALAPSAPSPPSLDLLARSVVNLGNAGNVAVSCTRLLQMRNAALHQMKVHYFYRQLLSESAWTPL 1529
XP_008112696  1236 AFPAAPCYMDPKDKLKALSPSAESPIAREHLAKRIVNLGHAGNLGTSCLRLGWLRSNTIHQMKVQHFYQQLLRDAVWTPL 1315
XP_002191097  1085 AFPAAPCGLDSKHQLKALSPSAEWPIGMENLCKRFVNLGNGGKLGISCTRLNFLRNKTVHEIKVQHFYQQLVSDLAWTPL 1164
XP_010711655   857 AFPAAPCCMDLKNKLKALSPSAEWPITMENLCKRIVNMGNGGKLGVSCTRLNWLRNKTAHDIKVQHFYQQLLSDLAWTPL 936 
10_pfamImport    1 GFPAAPCCVDPRFKLRALAPSAPEQTSMADLARGVVNLGNSGTLSLSSTRLLRMREEVIHQMRVHYYYQQLLDERVWEPL 80  
XP_028925526  1143 VFPAAPCYVENTNELKALLPSAECPIPKEYFSKGILDLGHAGKLGISCIRLNRLRNEMIHQMKVQYFYQKLLREAAWTPL 1222 platypus
XP_012405535  1258 AFPAAPCCVDLSNRLQALSPSAECPIAKENLAKGVLNLGHAGKLGLSCTRLRWMRNKTIHQMKVQYFYQQLLSEAVWTPL 1337 Tasmanian devil
XP_028924448   638 AFPAAPCCVDQNDRLKALSPSAECPIAEENLARGILDLGNAGKLGVYCTRLRWLRNKAIHQMKVQYFYQQLVSEAAWSPL 717  platypus
XP_022535919  1385 GFPAAPCCVDPRFKLQALAPSAPPTPSVESLAQGYVNLGNSGNMVVSCTRLFKTRNDTFRQMRVNFFYNLLLS-VVWRPL 1463 Mexican tetra
XP_005997746  1455 VFPAAPAAHDLRCNLQALAPSAS--ITQESLAKGVVNLGHAGSLEVSCTRLLHMRQETIHKMKVQYFYEQLLCDAAWAPL 1532 coelacanth
XP_006636742  1530 DLPSLVAESFPSPANRIYWKAALLLPSNEECEMSVTNSILTDWLKAKFgG--RENSENMEQNQNDKIQTLSICNGLRNHG 1607
XP_008112696  1316 DLPSLVAENIPVQQEKVFWKALLVLPSYEEYPAKDPSRILADWLKAKF-Gi-DKNLEEATSVENDGIKTLALHTSLRTQR 1393
XP_002191097  1165 DLVSLITEHIPVQQEQVFWKVLLVLPSDDEYSKDDPNRILVDWLKAKFmG--HRSDEKNASHTESKIQTLTLFSSPGMQG 1242
XP_010711655   937 DLASLIAEHIPIKQDQVFWKVLLVLPNDDEYEEDDPNRILIEWLKAKFlK--DRSWKKTASCEEVRIQTLTLFNSSGVRG 1014
10_pfamImport   81 DLPALVTENIPNLPDRIFWKAVLLLPSDHESVATLADRILSDWLEVKLgG--GKGSEVREEQLDGTLQTLCVTNTLRDEG 158 
XP_028925526  1223 DLPSLISEHLALQREHVFWKVVLVLPDNEMHPSGDLSRILGNWLKVKFmG--AEISKKVNNNAKDKIQTLALFQYIKQQE 1300 platypus
XP_012405535  1338 DLPALIAEHYPGQREQVFWKLVLVLPDSEEPASGYSSRILANWLKVKFmG--YEDLQKGARHASEGIQTLTLLNACSTKG 1415 Tasmanian devil
XP_028924448   718 NLPSLIAEHHPGQKEQVFWKLVLVLPESEETPSGYPSGILSDWLKVKFmG---EVPSGESCGAKDRIQTLALFNSVGYRG 794  platypus
XP_022535919  1464 DLPTLVAESTPNPPNRIFWKATLLLPSNEDTDMSFANSTLTKWLEVKMgGrdKEEEDGSMAEVEGKLETLLISNNLRDVG 1543 Mexican tetra
XP_005997746  1533 DLPSLIAETFPSPSNRIFWKMILLLPSCEEPHTNETNRVLAEWLKAKFrG--DGQLEDETTDPEDKLQTLALYSSSRTRE 1610 coelacanth
XP_006636742  1608 DKSQNVHICIKVTHGPLSLEGMSQMERQKDVLGTSALLLLLPSlpgyGA-TEEKEELDVYLLSALLQLKQIQQVYSWQSA 1686
XP_008112696  1394 DRDIYVSACIKTTHGTLSTSEVEDPGIQKKLLGTSGLILLLSP----RVrSEDVAEEDIYWLSALLQLKRLLQAKPYQPI 1469
XP_002191097  1243 TRSIKVSVCIKVAHGLLSNSELDLAETQKDLLGTSGLVLLLPP----RVsSEDIAEDDVYWLSALLQLKQLLQAKPFHPI 1318
XP_010711655  1015 SRNIKVSVCIKVVHGVLSDSELDASSTQKDLLGTSGLILLLPP----QVrSEDVAEEDVYWLSALLQLKQLLQAKPFQPT 1090
10_pfamImport  159 QRTHKVHISIKASRGPLTEDGLCKTEECCDLQGTGALIVLLPAmpimDPgSDDQ---DVPLLSALLQLKQLQQASAWHCP 235 
XP_028925526  1301 DWATQVNVCVKVVQGILSDAELETAKSQKDFLGTSGFILLLPV----REkNEDSTKIDEFWFSALLQLRKLLEAKPVLPV 1376 platypus
XP_012405535  1416 NRTVWVNVCIKVAHGLLSDSALDATETQKDLLGTSGLLFLLPA----PGkSVMVAEEDTYWLSALLQLKQLLQAKPFHPL 1491 Tasmanian devil
XP_028924448   795 DRTICVNVCVKVAHGALSDSALDAAETQRDLLGTSGLILLLPP----RIgSEDFAEEDVYWLSALLQLKQLLQAKPFRPV 870  platypus
XP_022535919  1544 QRTHKVHICVKVSRGPLTDEGQSQLEEQKELLGTSALLMMLPLlpsaDQsELRQGEEDVPLLAALLQLKQVQEASGWNSP 1623 Mexican tetra
XP_005997746  1611 GQPVNVHVCIKVACGPLSEDRLDQTESQKDLLGTSGLVMLLLV----GAgGGDVEQEDVYWLSALLQLKQLLQAKPFRPA 1686 coelacanth
XP_006636742  1687 LPLVVVVPKHAEQPTCEEkLEEGLMLQALVEENLISEYIFVHVPHSTNDLQGSEQIHQAVKWLVSRSPAAPDLSSQTLVQ 1766
XP_008112696  1470 VPLVVLVPSRGDEAAEKE-VEEGLMLPDLISANLISGYKVVEIPDSVSDLQGTRKLSEAVQWLVTQYPSSINLCCQTLRQ 1548
XP_002191097  1319 VPLVVLVPSQKEKAVEKE-VEDGLMLQDLISAHLISDYTIVELPGSVNDLEGTRRVSAAVGWLVSHCPASLELCSQTLQE 1397
XP_010711655  1091 VPLLVLVPSLEEEATEKE-VEEGLMLQDLISAQLISDYIIVELPGSINDLEGTRRISAAMSWLVSQCPNSLELCSQTLQE 1169
10_pfamImport  236 LPLAILVPGTECANGDVQkLEEALMLHTLVQEGMISEYTFYFIPETTSDLQGSKQLSQATRWLLARAPPPFPLSCQTLVQ 315 
XP_028925526  1377 IPLIILVPIQGKDEIEKD-VEKGLLLQDLISSELISDYIIVKISSFLNDLEANLQVSKAVKWLASHSPRHPKLCCQTLSQ 1455 platypus
XP_012405535  1492 VPLVVLVPGQEGASVR-D-VEEGLMLQDLVSSQLISDYIVVEIPAAVNDLQGTNRVSQAVKWLVSHCPSSLELCCQTLPH 1569 Tasmanian devil
XP_028924448   871 VPLVVLVPNRGGDTGERE-VEEGLMLQDLVSAKLISDYIIVEIPDSVSDLRGTNRVSASVKWLVAHCPGSLELCCRTLLQ 949  platypus
XP_022535919  1624 LPLALIIPGQPEGAISDEkLEEVLQLKTLVNDGIISEYVFIRVAGSVSDIQGSQQIGEAVRWLVAHSPASTVLSSQPLVQ 1703 Mexican tetra
XP_005997746  1687 VPLLILFSPQGEEAVSKDqVEEGLMLQDLVAAKLISEYHIVEMPGLMTDLHGANRVSQSVKWLVSHCPSSVALCSRTLLQ 1766 coelacanth
XP_006636742  1767 FVEDGLCREFSTRFYHDKTERQASGLPCQEPAPIIELYNSVLRFLAGLVSSEQFSRLSWPVAEFSVPRPQNLLPHLEWNS 1846
XP_008112696  1549 YVEDGLDLLFSQQFYLDRKERYTAGLCAQDPSAVIELYNNAVQFLAEVVSSEDLYDLSWPVIEFAEPGGSKLLPHLQWNM 1628
XP_002191097  1398 YIEDGIDGEFGKRFYHDWKERRLAGLPSQEPGVIIELYNSVLQFLSDVASSEHFYDLSWPVTEFSEAGGNKMLPHLQWNM 1477
XP_010711655  1170 YIEDGIDGEFGKRFYHDWKERRLAGLPSQEPGVIIELYNNVLQFLSEVASSEHLCDLSWPVTEFSEPGGNKLLPHMDWNV 1249
10_pfamImport  316 LVEASLSREFSPRVHAHRQERVAARLPSQSPVPVIQLYNSVLAHIADKVSSRDLGKLSWPPGEFCLHDTREFIPHLGWNS 395 
XP_028925526  1456 FVEDGVHREFSRRFFWDRKERRLAGLASQKPGPIIDLYNSVLQFLADVISSEWLSNLSWPVPEFAEPEGTGQLPHLYWNT 1535 platypus
XP_012405535  1570 YIEDGVSREFSDRFFYDRKERRVAGLASQEPGAIIELFNGVLQFLADVASSEQLCHLSWPITEFAEPGGNKVLPHLQWNA 1649 Tasmanian devil
XP_028924448   950 FVEDGLSFEFSDRFFHDRRERRLAGLPSQEPGAVIELYNSVLQFLATVASSERLCDLSWPVTEFAEPGGSELLPHLRWNT 1029 platypus
XP_022535919  1704 FVESGLCREFHTRFHRDKQERMQAGLMCQDSTAIIQLYNSVLCYLADLVSCEQMIGISWPPPEFSLPENRDLVPHLDWNS 1783 Mexican tetra
XP_005997746  1767 YLEDGLCNEFNDRFYTDKIERQVAGLPSQDPHAVIELYNSVLDFLAEVASSEELCDLSWPISEFVGPGSSETFPHLQWNT 1846 coelacanth
XP_006636742  1847 PEHLAWLNRAILTLQIPDWDLPAQHASWPGLCARIFQFVAQIPFSRHSHPLLVSKVGHLLKRVHSEWMRGAMSAq----- 1921
XP_008112696  1629 PKHLSWLRKAVLSFQIPHMDLPPSGAPWHLVCAMIFQYVSQTASSPQSQEILQSQIENLLSRTYLKWKDKKSMQ------ 1702
XP_002191097  1478 PDHLAWLRKAVLSFQIPYLDLPPLGAPWHPVCHMIFQYVSQIASSSHTQPLIQSQVENLLSKTYQNWKTRTTGN------ 1551
XP_010711655  1250 PDHLAWLKKAVLSFQIPYLDLPPLGAPWRPVCRMIFQYASQIASSSHTQPLIQSQVENLLSRTYQKWKNGPLGN------ 1323
10_pfamImport  396 AQHQEWLREVILSLQLPQWEQLCTTDSWSALCSSIFRYAAQIPVSQRSQPLLMSRLENILERVRLKSLHTRTRAsnaams 475 
XP_028925526  1536 PRHLAWLKEAVLSFQIPQIDIPP-SAPWNFICTTIFQYISQIPSSHQTQPVLQVQVENLLSGIYFKLKDKELAS------ 1608 platypus
XP_012405535  1650 PSHLAWLKKVILSFQLPHMDLPPPGAPWRRVCNMISQYVSQIPSCCQTQPILQSQVENLLSRTYGKWRNKDPWA------ 1723 Tasmanian devil
XP_028924448  1030 PDHLAWLKKAVLSFQIPQMDLPPLGAPWRPVCSMIFQYVSQIPSCRQTQPILQSQVENLLSRTYSEWKRKVPAS------ 1103 platypus
XP_022535919  1784 PQHLAWLKRTVLSLQIPEWDQPPINASWPHLCTSIFHYVSQIPSSPQSQPLLMSRLEHLLARVRAQHMQDGREDee---- 1859 Mexican tetra
XP_005997746  1847 AEHLAWLRKAVLSFKLPEMDRLIVQAPWNAACRSISQYVSQIATSLHTQTMLISQVECLLNRVYTRWMDSEAAA------ 1920 coelacanth
XP_006636742  1922 --eEEEAGPAFQQVPWDEIVALCIDHRLKDWKPPESPVTEDA-----------------ITDDGEILVYFVKEDLKKYEP 1982
XP_008112696  1703 ---SSKDGPSVEEIPWDSMLALCINHKLRDWKPPCLPVAPEA-----------------VNEDGQIHVYFFKEHLGRFGC 1762
XP_002191097  1552 ---SDEDGPSVDEIPWDCILAVCIDHKLRDWKPPKLPVAPEA-----------------ISKDGQIRVYFFKGHLENYSV 1611
XP_010711655  1324 ---TG-DGPSVDEIPWDDILATCIDHKLRDWKPPKLPVAPEA-----------------VSEDGQIRVYYFKEHLKNFTL 1382
10_pfamImport  476 nwnEESACPAFSQVPWDDVVVICIDHKLKDWQIPGLPICEDA-----------------VTDDGEILVYLPAESLKGFQP 538 
XP_028925526  1609 ---SGEGGFSVKDIPWDAIISLCINHRLKDWMPLTLPTVSEA-----------------LSRDGEIRVYFSKDHLSEFTR 1668 platypus
XP_012405535  1724 ---LGQTGPCVEEIPWDDLIALCINHKLRDWKPPRLPVTSEA-----------------LSEDGQICVYFFKTHLKSYEV 1783 Tasmanian devil
XP_028924448  1104 ---SGESGPTVEEIPWDDVLALCINHRLRDWKPPKPAVSSEA-----------------VSEDGQICVYFFKEHLKKYQL 1163 platypus
XP_022535919  1860 -dtDEKAGPSFSRIPWDDILFLCIEHRMKDWSLPESPVTEDA-----------------FTDSGEILVYYIKKQVMDFMP 1921 Mexican tetra
XP_005997746  1921 ---WGDNGPSAQEIPWDDLLTLCINHRLRDWKPPGSPLESGThlwagcpdqsqqkqpsrLALRSHVACRSV------MDF 1991 coelacanth
XP_006636742  1983 PSSWLWAVRKTHKDKQqESFGfkLSP-------------ARVStPRLLHSRQRLFDSPVEKPGHATV---------ADIT 2040
XP_008112696  1763 PFSWEEARLKTQKMSQ-QSQG--RSK-------------IKTT-SFARLYSPSLSPAEFWASEGKARnteltvpsgADLT 1825
XP_002191097  1612 PFSWDQARLRTQEEIR-QGHE--RSK-------------IKYPkSYKKPYSFSMVPGQYDSGMLPRQevsv--pstDEFR 1673
XP_010711655  1383 PFSWEQARLRTQEEIR-QGHK--RSR-------------VKSPvSFKKPC-RVSMSDQYGAGVSILSgqrrnvssaDELR 1445
10_pfamImport  539 PEEWTEATRQTHRQKQqETDG--ADA-------------AACAtPSSLSLRQRLFSSLVEPLEDPAAr--------LDIT 595 
XP_028925526  1669 PSSWERARLRTQREIQ-QSYE--RSV-------------SDSNqSSKPNDGLGMTVERNDGRGRVTPgkkkeylpvEASD 1732 platypus
XP_012405535  1784 PRSWEHARLQTQKEIQrHSHG--GLG-------------IKPLlS-AKSLSSAWFHVPYCGARTPETgnashvpdgKELA 1847 Tasmanian devil
XP_028924448  1164 PLSWEQARLQTKKEIQ-QSQG--SLG-------------IKSPeSSARKCAPSLLQMPFNVIRKPGNgkegripsaEELI 1227 platypus
XP_022535919  1922 PESWVTAVKLTHKQKQkNLNGskESP-------------VVASsPSAHFPRQRLFQSRIEPEESPTA---------LDIT 1979 Mexican tetra
XP_005997746  1992 TKALETRSPSVVDSAHtPSAQnlSPQclddtfekgeeesHRLQkKPSYSTPESLVARR--SLTAIKKslemelssiADIT 2069 coelacanth
XP_006636742  2041 HTPSSRELLPHRLLSSLEAERAQSQRFEEQLQQWLEVDP---LDSFSMP-------LFMPSTL-ISVPEIMAasqrafPA 2109
XP_008112696  1826 VTVSEIDALPECLSVKLQQEKAESRRFDERLQQLLVQDSeifQDSPSLP-------LYLPETL-VCVPQIIQ------PL 1891
XP_002191097  1674 DTSLAQEHL----LAQLQLEKIENKRFEEQLHQYLAEDMeplEDLLGLP-------LYLPQSL-LSTPAATC------P- 1734
XP_010711655  1446 --ASAQD-LPERLLTQLKLEKVESRRFEEQLHQYLAEDIeplGDLMGFP-------LYLPQSL-ISTPTLAG------P- 1507
10_pfamImport  596 HTPTAPELVAHKVFRILEKEKAESKRSMEQLQRWLDGDS---LDYLSTP-------LFVPSSTlLSTPTAIMc-----AP 660 
XP_028925526  1733 PSFSREELLSAHLSTCLQQEREESKKFEDQIQQWLTEDPgqlK--VSLPqqftpvnLLQPVALgVNTPALIE-------- 1802 platypus
XP_012405535  1848 RTASAEELLPGRLSATLQREKEESRRFEDQLRHWLARDHeqgPDSSPLP-------IYLPQAL-LSTPQTLQ------PF 1913 Tasmanian devil
XP_028924448  1228 HTASAEELLPERLTSGIQLEKEENKRFEDKLHQWLAEDSvqlADSTALP-------LYLPQAL-VSVPQAIR------P- 1292 platypus
XP_022535919  1980 HSLSPQELLPHRLLASIQQEKAQSQRFEEQLQRWLEVDP---LDSVSMP-------LFMPSTL-LCVPEILTp-----SR 2043 Mexican tetra
XP_005997746  2070 HTLSAEELLPQRLQDSIEKEKKESEKFEEQLQQWLSEDPl--KQSFPFP-------VYLPQSL-VSIPEAIPv-----PF 2134 coelacanth
XP_006636742  2110 SAAVSL-----SMEAGVPGekwdrsGQRGCPVSMEQRLQDLDRQIRASKEEELACELQLSSLLD 2168
XP_008112696  1892 AKPSMA-----KSPEAGKK------ELPDPDTSLSHRLQYLKQQIRANKEEEIACETHLSTLLD 1944
XP_002191097  1735 LVKSPM-----SAAQEAGSqekhkiPEMEQSSALSDRLKHLQQLLRATKEAEAASELHLSALVD 1793
XP_010711655  1508 LIKSPM-----SSVQVDGSearfelSIDDRSPALSDRLKHLQRLLRADREGEVASELHLSALMD 1566
10_pfamImport  661 SAVVTQ-----EPEQDHLSdka--drSKTKPLSIEWQLKELKRQILASHEEELACRLKLSGLLN 717 
XP_028925526  1803 -------------LQVSRQmen-trSMQEPSTSLSKRLRHLENLIRATREEDRVFDLQLSTLRD 1852 platypus
XP_012405535  1914 LRVSAT-----SSHQEQKAtew-qrPAPATVLSLNDKLRRLESLIQLTREEDLVCERHLSTLLD 1971 Tasmanian devil
XP_028924448  1293 PSESPR-----TSPQNAGAaerkrtAAPDEDLSLSDRLKHLERLIKSTKEEEIACERHLSTLLD 1351 platypus
XP_022535919  2044 RPAASAacfkkDTESDDFAekvpssCRRDTPVSLTQRLEELDRLIKANREEELACSLKLKGLLE 2107 Mexican tetra
XP_005997746  2135 RTSPSA-----DLQGKNRSklelsdQASETTVPISDQLKKLDRLIKTNKEEDLACELHLSALLD 2193 coelacanth
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